Gary Glover

Postdoctoral Advisees

Rachel Bitton

Web Site Links

• http://rsl.stanford.edu/glover

Research Interests

The work in the Radiological Sciences Laboratory is devoted to the advancement of imaging sciences for applications in diagnostic radiology. We collaborate closely with departmental clinicians and with others in the school of medicine, humanities, and the engineering sciences. The laboratory's activities include development of both CT and MR imaging techniques, with spiral CT Angiography, an example of the former. Work is underway in developing MRI methods for quantitative blood flow imaging, spectroscopic imaging methods for metabolite quantitation, RF pulse design and application, rapid scanning methods, imaging of cardiac and muskuloskeletal dynamic functions, and development of magnetization transfer and other specialized sequences for alternative contrast mechanisms. Applications include breast cancer and renal function imaging.

Presently my research is directed in part towards exploration of rapid scanning methods using spiral and other non-Cartesian k-space trajectories. Using spiral techniques, we have developed MRI pulse sequences and processing methods for mapping cortical brain function by imaging the metabolic response to various stimuli, with applications in the basic neurosciences as well as for clinical applications. These methods develop differential image contrast from hemodynamically driven increases in oxygen content in the vascular bed of activated cortex, using pulse sequences sensitive to the paramagnetic behavior of deoxyhemoglobin or to the blood flow changes.

Publications

• Performance-related sustained and anticipatory activity in human medial temporal lobe during delayed match-to-sample. Olsen RK, Nichols EA, Chen J, Hunt JF, Glover GH, Gabrieli JD, Wagner AD. J Neurosci. 2009; 29 (38): 11880-90
• Development, validation, and comparison of ICA-based gradient artifact reduction algorithms for simultaneous EEG-spiral in/out and echo-planar fMRI recordings. Ryali S, Glover GH, Chang C, Menon V. Neuroimage. 2009; 48 (2): 348-61
• Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. Chang C, Glover GH. Neuroimage. 2009; 47 (4): 1448-59
• Interleaved spiral-in/out with application to functional MRI (fMRI). Law CS, Glover GH. Magn Reson Med. 2009; 62 (3): 829-34
• Optimizing saturation-recovery measurements of the longitudinal relaxation rate under time constraints. Hsu JJ, Glover GH, Zaharchuk G. Magn Reson Med. 2009; 62 (5): 1202-10