Publications
-
SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.
Chang WP,
Südhof TC.
J Neurosci.
2009;
29
(4):
883-97
-
Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons.
Gibson JR,
Huber KM, Südhof TC.
J Neurosci.
2009;
29
(44):
13883-97
-
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.
Tabuchi K,
Chen G, Südhof TC, Shen J.
J Neurosci.
2009;
29
(22):
7290-301
-
Membrane fusion: grappling with SNARE and SM proteins.
Südhof TC,
Rothman JE.
Science.
2009;
323
(5913):
474-7
-
A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export.
Zhang C,
Milunsky JM, Newton S, Ko J, Zhao G, Maher TA, Tager-Flusberg H, Bolliger MF, Carter AS, Boucard AA, Powell CM, Südhof TC.
J Neurosci.
2009;
29
(35):
10843-54
-
Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation.
Ko J,
Zhang C, Arac D, Boucard AA, Brunger AT, Südhof TC.
EMBO J.
2009;
28
(20):
3244-55
-
Presenilins are essential for regulating neurotransmitter release.
Zhang C,
Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J.
Nature.
2009;
460
(7255):
632-6
-
Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery.
Deák F,
Liu X, Khvotchev M, Li G, Kavalali ET, Sugita S, Südhof TC.
J Neurosci.
2009;
29
(27):
8639-48
-
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.
Deák F,
Xu Y, Chang WP, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J.
J Cell Biol.
2009;
184
(5):
751-64
-
Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas.
Gustavsson N,
Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W.
J Physiol.
2009;
587
(Pt 6):
1169-78
-
Complexin controls the force transfer from SNARE complexes to membranes in fusion.
Maximov A,
Tang J, Yang X, Pang ZP, Südhof TC.
Science.
2009;
323
(5913):
516-21
-
Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2.
Blundell J,
Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM.
Genes Brain Behav.
2009;
8
(1):
114-26
-
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release.
Shin OH,
Xu J, Rizo J, Südhof TC.
Proc Natl Acad Sci U S A.
2009;
106
(38):
16469-74
-
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments.
Etherton MR,
Blaiss CA, Powell CM, Südhof TC.
Proc Natl Acad Sci U S A.
2009;
106
(42):
17998-8003
-
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
Kaeser PS,
Deng L, Chávez AE, Liu X, Castillo PE, Südhof TC.
Neuron.
2009;
64
(2):
227-39
-
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release.
Xu J,
Pang ZP, Shin OH, Südhof TC.
Nat Neurosci.
2009;
12
(6):
759-66
-
Neuroligins and neurexins link synaptic function to cognitive disease.
Südhof TC,
Nature.
2008;
455
(7215):
903-11
-
Understanding synapses: past, present, and future.
Südhof TC,
Malenka RC.
Neuron.
2008;
60
(3):
469-76
-
RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions.
Kaeser PS,
Kwon HB, Chiu CQ, Deng L, Castillo PE, Südhof TC.
J Neurosci.
2008;
28
(50):
13435-47
-
Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.
Ho A,
Liu X, Südhof TC.
J Neurosci.
2008;
28
(53):
14392-400
-
RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.
Kaeser PS,
Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Südhof TC.
Proc Natl Acad Sci U S A.
2008;
105
(38):
14680-5
-
Conformational switch of syntaxin-1 controls synaptic vesicle fusion.
Gerber SH,
Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC.
Science.
2008;
321
(5895):
1507-10
-
Cysteine string protein-alpha is essential for the high calcium sensitivity of exocytosis in a vertebrate synapse.
Ruiz R,
Casañas JJ, Südhof TC, Tabares L.
Eur J Neurosci.
2008;
27
(12):
3118-31
-
Unusually rapid evolution of Neuroligin-4 in mice.
Bolliger MF,
Pei J, Maxeiner S, Boucard AA, Grishin NV, Südhof TC.
Proc Natl Acad Sci U S A.
2008;
105
(17):
6421-6
-
CASK Functions as a Mg2+-independent neurexin kinase.
Mukherjee K,
Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC.
Cell.
2008;
133
(2):
328-39
-
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice.
Gustavsson N,
Lao Y, Maximov A, Chuang JC, Kostromina E, Repa JJ, Li C, Radda GK, Südhof TC, Han W.
Proc Natl Acad Sci U S A.
2008;
105
(10):
3992-7
-
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis.
Maximov A,
Lao Y, Li H, Chen X, Rizo J, Sørensen JB, Südhof TC.
Proc Natl Acad Sci U S A.
2008;
105
(10):
3986-91
-
Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells.
Schonn JS,
Maximov A, Lao Y, Südhof TC, Sørensen JB.
Proc Natl Acad Sci U S A.
2008;
105
(10):
3998-4003
-
A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.
Gallardo G,
Schlüter OM, Südhof TC.
Nat Neurosci.
2008;
11
(3):
301-8
-
Munc18-1 binds directly to the neuronal SNARE complex.
Dulubova I,
Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J.
Proc Natl Acad Sci U S A.
2007;
104
(8):
2697-702
-
Deletion of CASK in mice is lethal and impairs synaptic function.
Atasoy D,
Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, Südhof TC.
Proc Natl Acad Sci U S A.
2007;
104
(7):
2525-30
-
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.
Min SW,
Chang WP, Südhof TC.
Proc Natl Acad Sci U S A.
2007;
104
(10):
3823-8
-
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons.
Xu J,
Mashimo T, Südhof TC.
Neuron.
2007;
54
(4):
567-81
-
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
Chevaleyre V,
Heifets BD, Kaeser PS, Südhof TC, Purpura DP, Castillo PE.
Neuron.
2007;
54
(5):
801-12
-
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission.
Bronk P,
Deák F, Wilson MC, Liu X, Südhof TC, Kavalali ET.
J Neurophysiol.
2007;
98
(2):
794-806
-
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2.
Chubykin AA,
Atasoy D, Etherton MR, Brose N, Kavalali ET, Gibson JR, Südhof TC.
Neuron.
2007;
54
(6):
919-31
-
Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution.
Guan R,
Dai H, Tomchick DR, Dulubova I, Machius M, Südhof TC, Rizo J.
Biochemistry.
2007;
46
(31):
8988-98
-
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines.
Wu H,
Xu J, Pang ZP, Ge W, Kim KJ, Blanchi B, Chen C, Südhof TC, Sun YE.
Proc Natl Acad Sci U S A.
2007;
104
(34):
13821-6
-
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation.
Maximov A,
Pang ZP, Tervo DG, Südhof TC.
J Neurosci Methods.
2007;
161
(1):
75-87
-
Membrane fusion as a team effort.
Südhof TC,
Proc Natl Acad Sci U S A.
2007;
104
(34):
13541-2
-
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K,
Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC.
Science.
2007;
318
(5847):
71-6
-
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.
Khvotchev M,
Dulubova I, Sun J, Dai H, Rizo J, Südhof TC.
J Neurosci.
2007;
27
(45):
12147-55
-
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse.
Sun J,
Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC.
Nature.
2007;
450
(7170):
676-82
-
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.
Maximov A,
Shin OH, Liu X, Südhof TC.
J Cell Biol.
2007;
176
(1):
113-24
-
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.
Araç D,
Boucard AA, Ozkan E, Strop P, Newell E, Südhof TC, Brunger AT.
Neuron.
2007;
56
(6):
992-1003
-
cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map.
Nicol X,
Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P.
Nat Neurosci.
2007;
10
(3):
340-7
-
Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.
Dudanova I,
Tabuchi K, Rohlmann A, Südhof TC, Missler M.
J Comp Neurol.
2007;
502
(2):
261-74
-
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release.
Pang ZP,
Sun J, Rizo J, Maximov A, Südhof TC.
EMBO J.
2006;
25
(10):
2039-50
-
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.
Lu J,
Machius M, Dulubova I, Dai H, Südhof TC, Tomchick DR, Rizo J.
PLoS Biol.
2006;
4
(7):
e192
-
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion.
Deák F,
Shin OH, Tang J, Hanson P, Ubach J, Jahn R, Rizo J, Kavalali ET, Südhof TC.
EMBO J.
2006;
25
(12):
2856-66
-
Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing.
Sheckler LR,
Henry L, Sugita S, Südhof TC, Rudenko G.
J Biol Chem.
2006;
281
(32):
22896-905
-
Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion.
Deák F,
Shin OH, Kavalali ET, Südhof TC.
J Neurosci.
2006;
26
(25):
6668-76
-
Neuroligins determine synapse maturation and function.
Varoqueaux F,
Aramuni G, Rawson RL, Mohrmann R, Missler M, Gottmann K, Zhang W, Südhof TC, Brose N.
Neuron.
2006;
51
(6):
741-54
-
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
Tang J,
Maximov A, Shin OH, Dai H, Rizo J, Südhof TC.
Cell.
2006;
126
(6):
1175-87
-
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.
Comoletti D,
Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Südhof TC, Taylor P.
Biochemistry.
2006;
45
(42):
12816-27
-
Synaptic vesicles: an organelle comes of age.
Südhof TC,
Cell.
2006;
127
(4):
671-3
-
Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
Schoch S,
Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Südhof TC.
EMBO J.
2006;
25
(24):
5852-63
-
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.
Pang ZP,
Shin OH, Meyer AC, Rosenmund C, Südhof TC.
J Neurosci.
2006;
26
(48):
12556-65
-
Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification.
Juranek J,
Mukherjee K, Rickmann M, Martens H, Calka J, Südhof TC, Jahn R.
Eur J Neurosci.
2006;
24
(11):
3043-52
-
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family.
Ho A,
Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC.
J Neurosci.
2006;
26
(50):
13089-101
-
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses.
Pang ZP,
Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, Südhof TC.
J Neurosci.
2006;
26
(52):
13493-504
-
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids.
Araç D,
Chen X, Khant HA, Ubach J, Ludtke SJ, Kikkawa M, Johnson AE, Chiu W, Südhof TC, Rizo J.
Nat Struct Mol Biol.
2006;
13
(3):
209-17
-
Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway.
Sun J,
Bronk P, Liu X, Han W, Südhof TC.
Proc Natl Acad Sci U S A.
2006;
103
(8):
2880-5
-
CSPalpha-deficiency causes massive and rapid photoreceptor degeneration.
Schmitz F,
Tabares L, Khimich D, Strenzke N, de la Villa-Polo P, Castellano-Muñoz M, Bulankina A, Moser T, Fernández-Chacón R, Südhof TC.
Proc Natl Acad Sci U S A.
2006;
103
(8):
2926-31
-
Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity.
Schlüter OM,
Basu J, Südhof TC, Rosenmund C.
J Neurosci.
2006;
26
(4):
1239-46
-
Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1.
Li L,
Shin OH, Rhee JS, Araç D, Rah JC, Rizo J, Südhof T, Rosenmund C.
J Biol Chem.
2006;
281
(23):
15845-52
-
Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation.
Nagy G,
Kim JH, Pang ZP, Matti U, Rettig J, Südhof TC, Sørensen JB.
J Neurosci.
2006;
26
(2):
632-43
-
C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1.
Han W,
Rhee JS, Maximov A, Lin W, Hammer RE, Rosenmund C, Südhof TC.
J Biol Chem.
2005;
280
(6):
5089-100
-
Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties.
Shin OH,
Han W, Wang Y, Südhof TC.
J Biol Chem.
2005;
280
(2):
1641-51
-
Selective capability of SynCAM and neuroligin for functional synapse assembly.
Sara Y,
Biederer T, Atasoy D, Chubykin A, Mozhayeva MG, Südhof TC, Kavalali ET.
J Neurosci.
2005;
25
(1):
260-70
-
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein.
Fornai F,
Schlüter OM, Lenzi P, Gesi M, Ruffoli R, Ferrucci M, Lazzeri G, Busceti CL, Pontarelli F, Battaglia G, Pellegrini A, Nicoletti F, Ruggieri S, Paparelli A, Südhof TC.
Proc Natl Acad Sci U S A.
2005;
102
(9):
3413-8
-
Are neuronal SNARE proteins Ca2+ sensors?
Chen X,
Tang J, Sudhof TC, Rizo J.
J Mol Biol.
2005;
347
(1):
145-58
-
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1.
Rhee JS,
Li LY, Shin OH, Rah JC, Rizo J, Südhof TC, Rosenmund C.
Proc Natl Acad Sci U S A.
2005;
102
(51):
18664-9
-
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.
Maximov A,
Südhof TC.
Neuron.
2005;
48
(4):
547-54
-
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration.
Chandra S,
Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC.
Cell.
2005;
123
(3):
383-96
-
RIM function in short- and long-term synaptic plasticity.
Kaeser PS,
Südhof TC.
Biochem Soc Trans.
2005;
33
(Pt 6):
1345-9
-
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins.
Boucard AA,
Chubykin AA, Comoletti D, Taylor P, Südhof TC.
Neuron.
2005;
48
(2):
229-36
-
Crystal structure of the RIM2 C2A-domain at 1.4 A resolution.
Dai H,
Tomchick DR, García J, Südhof TC, Machius M, Rizo J.
Biochemistry.
2005;
44
(41):
13533-42
-
Nicastrin functions as a gamma-secretase-substrate receptor.
Shah S,
Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE, Südhof T, Yu G.
Cell.
2005;
122
(3):
435-47
-
Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide.
Lu J,
Li H, Wang Y, Südhof TC, Rizo J.
J Mol Biol.
2005;
352
(2):
455-66
-
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
Dulubova I,
Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Südhof TC, Rizo J.
EMBO J.
2005;
24
(16):
2839-50
-
Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation.
Huang YY,
Zakharenko SS, Schoch S, Kaeser PS, Janz R, Südhof TC, Siegelbaum SA, Kandel ER.
Proc Natl Acad Sci U S A.
2005;
102
(26):
9365-70
-
Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation.
Toonen RF,
de Vries KJ, Zalm R, Südhof TC, Verhage M.
J Neurochem.
2005;
93
(6):
1393-400
-
v-SNAREs control exocytosis of vesicles from priming to fusion.
Borisovska M,
Zhao Y, Tsytsyura Y, Glyvuk N, Takamori S, Matti U, Rettig J, Südhof T, Bruns D.
EMBO J.
2005;
24
(12):
2114-26
-
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels.
Zhang W,
Rohlmann A, Sargsyan V, Aramuni G, Hammer RE, Südhof TC, Missler M.
J Neurosci.
2005;
25
(17):
4330-42
-
CAPS in search of a lost function.
Südhof TC,
Neuron.
2005;
46
(1):
2-4
-
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA,
Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC.
J Biol Chem.
2005;
280
(23):
22365-74
-
Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release.
Calakos N,
Schoch S, Südhof TC, Malenka RC.
Neuron.
2004;
42
(6):
889-96
-
Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Schlüter OM,
Fornai F, Alessandrí MG, Takamori S, Geppert M, Jahn R, Südhof TC.
Neuroscience.
2003;
118
(4):
985-1002
-
RIM1alpha is required for presynaptic long-term potentiation.
Castillo PE,
Schoch S, Schmitz F, Südhof TC, Malenka RC.
Nature.
2002;
415
(6869):
327-30
-
Mapping of synapsin II (SYN2) genes to human chromosome 3p and mouse chromosome 6 band F.
Li X,
Rosahl TW, Südhof TC, Francke U.
Cytogenet Cell Genet.
1995;
71
(3):
301-5
-
Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse.
Ozçelik T,
Lafreniere RG, Archer BT, Johnston PA, Willard HF, Francke U, Südhof TC.
Am J Hum Genet.
1990;
47
(3):
551-61
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