Stanford School of Medicine
Neuroscience Institute at Stanford–

Pak H. Chan

Email:
Profile: http://med.stanford.edu/profiles/Pak_Chan/
Academic Appointments
Appointment
Organization
Professor
Neurosurgery
Graduate & Fellowship Program Affiliations
Neurosciences ;
 
Honors & Awards
Title
Organization
Date(s)
James R. Doty Professor in Neurosurgery and Neurosciences
Stanford University
2007
Mencius Type A & Type B Scholarships
Chinese University of Hong Kong
1960-1961
University Scientific Achievement Scholarship
Chinese University of Hong Kong
1962-1963
Jacob Javits Neuroscience Investigator Award
National Institutes of Health
1997-2004
Bugher Foundation Award
American Heart Association
2001-2004
15  honors and awards: view full list
Administrative Appointments
Title
Organization
Start Year
End Year
Director of Research, Department of Neurosurgery
Stanford University School of Medicine
1997
-
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
BS
Chinese University of Hong Kong
Biology
1964
MA
UCLA
Biochemistry
1970
PhD
UCLA
Biology
1972
Research Interests

My primary research interest is to understand the molecular and cellular mechanisms of cell death in the CNS following acute injuries such as ischemia and trauma and chronic neurodegenerative diseases. We focus on the role of oxidative stress, mitochondrial dysfunction, DNA damage and repair, various gene expressions (gene family of HSP72, Bcl-2, c-fos and COX-2) and various transcription factors (NF-kappaB, AP1, p53) in the pathogenesis of necrosis and/or apoptosis. Various transgenic and knockout mutant mice of CuZn-superoxide dismutase (SOD1) and mitochondrial manganese SOD (SOD2) have been generated to address the role of superoxide radicals in these cell death processes. In addition, human SOD1 transgenic rats have been established as a model for the study of oxidative mechanisms and acute and chronic CNS injuries. The long-term goal of our research is to derive therapeutic strategies at the cellular and molecular level to ameliorate cell death in CNS injuries.

Publications
  • Kamada H, Yu F, Nito C, Chan PH "Influence of Hyperglycemia on Oxidative Stress and Matrix Metalloproteinase-9 Activation After Focal Cerebral Ischemia/Reperfusion in Rats. Relation to Blood-Brain Barrier Dysfunction." Stroke 2007; More »
  • Suh SW, Gum ET, Hamby AM, Chan PH, Swanson RA "Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase." J Clin Invest 2007; 117: 4: 910-918 More »
  • Yu F, Narasimhan P, Saito A, Liu J, Chan PH "Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury." J Cereb Blood Flow Metab 2007; More »
  • Saito A, Hayashi T, Okuno S, Nishi T, Chan PH "Modulation of Proline-Rich Akt Substrate Survival Signaling Pathways by Oxidative Stress in Mouse Brains After Transient Focal Cerebral Ischemia." Stroke 2006; More »
  • Maier CM, Yu F, Nishi T, Lathrop SJ, Chan PH "Interferon-{beta} Fails to Protect in a Model of Transient Focal Stroke." Stroke 2006; More »
107 publications:   view full list

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