Miriam B. Goodman

Honors and Awards

• Klingenstein Fellow in Neuroscience, The Klingenstein Fund (2005-2008)
• McKnight Scholar Award, McKnight Endowment (2005-2008)
• Prize in Neurobiology, Eppendorf & Science (2004)
• Alfred P. Sloan Fellow, Alfred P. Sloan Foundation (2002-2004)
• Terman Fellow, Stanford University (2002-2005)

Professional Education

• Ph.D., The University of Chicago, Neurobiology (1995)
• Sc.B., Brown University, Biochemistry (1986)

Postdoctoral Advisees

Juan Cueva, Amy Eastwood, Shana Geffeney, Dominique Glauser

Graduate & Fellowship Program Affiliations

• Biophysics
• Molecular and Cellular Physiology
• Neurosciences

Web Site Links

• Goodman Lab Site

Research Interests

We study the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering (http://microsystems.stanford.edu) to develop and fabricate novel devices for the study of sensory transduction.

Publications

• Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons. Cueva JG, Mulholland A, Goodman MB "J Neurosci" 2007 ; 51 (27) : 14089-98
• The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. O'Hagan R, Chalfie M, Goodman MB "Nat Neurosci" 2005 ; 1 (8) : 43-50
• Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Chalasani SH, Chronis N, Tsunozaki M, Gray JM, Ramot D, Goodman MB, Bargmann CI "Nature" 2007 ; 7166 (450) : 63-70
• Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade. Brown AL, Fernandez-Illescas SM, Liao Z, Goodman MB "J Gen Physiol" 2007 ; 2 (129) : 161-73
• Mechanosensation. Goodman MB, "WormBook" 2006 : 1-14