Neurology &
Neurological Sciences

Department: Neurology & Neurological Sciences

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  • Academic Appointments Professor,  Biology (School of Humanities and Sciences)
    Member,  Bio-X
    Professor,  Neurosurgery
    Professor,  Neurology & Neurological Sciences
  • Academic Appointments Clinical Associate Professor,  Neurology & Neurological Sciences
    Clinical Assistant Professor,  Neurosurgery
    Clinical Focus
    • Neurology
    • Vascular Neurology
    Research Interest

    My clinical interests involve inpatient and outpatient care of patients with neurovascular diseases, mostly ischemic and hemorrhagic stroke. I have a particular interest in cervical artery dissection, non-atherosclerotic vasculopathies, and stroke in the young.

  • Academic Appointments Emeritus Faculty, Acad Council,  Neurology & Neurological Sciences
  • Academic Appointments Professor - Med Center Line,  Neurology & Neurological Sciences
    Clinical Focus
    • Neuropathy
    • Myasthenia Gravis
    • Amyotrophic Lateral Sclerosis
    Research Interest

    Research in the diagnosis, pathophysiology and treatment of peripheral neuropathy, motor neuron diseases including ALS and SMA, nerve injuries and muscle diseases. Application of clinical neurophysiological methods to neurological diagnosis. Neurological complications of HIV infection. Development of evidence-based medicine pertaining to the practice of neurology.

  • Academic Appointments Professor,  Pathology
    Professor (By courtesy),  Neurology & Neurological Sciences
    Clinical Focus
    • Anatomic Pathology
    • Diagnostic neuropathology
    Research Interest

    We study cellular and molecular mechanisms of immune-mediated injury in central nervous system (CNS) tissues that are altered in multiple sclerosis (MS). Tissues of patients and of animals with experimental allergic encephalomyelitis are analyzed using histology and immunohistochemistry. We currently are studying the cross-recognition of neurons by antibodies against myelin proteolipid protein epitopes. Similar cross-recognition may link anti-myelin immunity with neurodegeneration in MS.

  • Academic Appointments Professor,  Neurosurgery
    Member,  Bio-X
    Professor (By courtesy),  Neurology & Neurological Sciences
    Clinical Focus
    • Cerebrovascular and Spinal Vascular Surgery
    • Intracranial Aneurysms
    • Intracranial/Intraspinal AVMs, AV fistulas, Cavernous Malformations
    Research Interest

    Our laboratory investigates the pathophysiology and treatment of acute cerebral ischemia, as well as methods to restore neurologic function after stroke. Treatment strategies include mild brain hypothermia, gene transfer therapy and stem cell transplantation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating patients with difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease.

  • Academic Appointments Professor,  Neurology & Neurological Sciences
    Member,  Bio-X
    Professor,  Pediatrics
    Clinical Focus
    • Neurology
    • Neurology, Pediatric
    • Multiple Sclerosis, Myasthenia Gravis, Immune Disorders
    Research Interest

    Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

  • Academic Appointments Professor,  Molecular & Cellular Physiology
    Professor (By courtesy),  Neurology & Neurological Sciences
    Professor (By courtesy),  Psychiatry & Behavioral Science
    Research Interest

    Information transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.

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