Eva Czirr

Publications

• The immunology of neurodegeneration. Czirr E, Wyss-Coray T. J Clin Invest. 2012; 122 (4): 1156-63
• Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. J Biol Chem. 2008; 283 (25): 17049-54
• Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S. J Biol Chem. 2007; 282 (34): 24504-13
• Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure. Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. J Neurochem. 2011; 116 (3): 385-95
• The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T. Nature. 2011; 477 (7362): 90-4
• Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein. Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S. Neurodegener Dis. 2009; 6 (1-2): 1-8