Neurobiology

Department: Neurobiology

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B

  • Academic Appointments
    • Assistant Professor, Neurobiology
    • Member, Bio-X
    Research Interest

    We study how the neural circuitry of the vertebrate retina encodes visual scenes. We use a combination of experimental and theoretical methods, including multielectrode extracellular array recording, intracellular recording, two-photon laser scanning imaging, and computational modelling.

  • Academic Appointments
    • Professor, Neurobiology
    • Professor, Neurology & Neurological Sciences
    • Professor (By courtesy), Ophthalmology
    • Member, Bio-X
    • Professor, Developmental Biology
    Research Interest

    Our lab is interested in the neuronal-glial interactions that underlie the development and function of the mammlian central nervous system.

  • Academic Appointments
    • Emeritus Faculty, Acad Council, Neurobiology

C

  • Academic Appointments
    • Associate Professor, Neurobiology
    • Member, Bio-X
    Research Interest

    My lab addresses two distinct questions. That is, how can precise patterns of neuronal connections be genetically programmed during development, and how, once formed, can such circuits be used to mediate complex visual behaviors? Using the fruit fly visual system as a model, we employ genetic approaches to manipulate the functions of genes and neurons. From this, we infer specific developmental roles for particular molecules, and infer specific computational roles for individual neurons.

D

  • Academic Appointments
    • Assistant Professor, Neurobiology
    • Member, Bio-X
    Research Interest

    Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders. We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain.

K

  • Academic Appointments
    • Professor, Neurobiology
    Research Interest

    Cellular mechanisms of sensory integration, attention and learning, studied in the central auditory system in developing and adult animals, using behavioral, systems, cellular and molecular techniques.

L

  • Academic Appointments
    • Professor, Biology (School of Humanities and Sciences)
    • Professor (By courtesy), Neurobiology
    • Member, Bio-X
    Research Interest

    We are studying how neural circuits are assembled during development, and how they contribute to sensory perception. We are addressing these questions at different levels from molecular, cellular, circuit to animal behavior. We are primarily using Drosophila as a model organism for our studies. Most recently, we are also developing novel genetic tools in the mouse to extend our studies to the mammalian brain.

M

  • Academic Appointments
    • Emeritus Faculty, Acad Council, Neurobiology
    • Emeritus Faculty, Acad Council, Structural Biology
    • Member, Bio-X
    Research Interest

    We are currently investigating mechanisms involved in synaptic transmission and synaptogenesis using electron microscope tomography in ways that provide in situ 3D structural information at macromolecular resolution.

  • Academic Appointments
    • Assistant Professor, Neurobiology
    • Member, Bio-X
    Research Interest

    We study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and

N

  • Academic Appointments
    • Professor, Neurobiology
    • Member, Bio-X
    Research Interest

    Neural processes that mediate visual perception and visually-based decision making. Influence of reward history on decision making.

R

  • Academic Appointments
    • Associate Professor, Neurobiology
    • Member, Bio-X
    Research Interest

    We study the neural mechanisms of learning, using a combination of behavioral, neurophysiological, and computational approaches. The model system we use is a form of cerebellum-dependent learning that regulates eye movements.

S

  • Academic Appointments
    • Professor, Biology (School of Humanities and Sciences)
    • Professor, Neurobiology
    • Member, Bio-X
    Research Interest

    The goal of research in the Shatz Laboratory is to discover how brain circuits are tuned up by experience during critical periods of development both before and after birth by elucidating cellular and molecular mechanisms that transform early fetal and neonatal brain circuits into mature connections. To discover mechanistic underpinnings of circuit tuning, the lab has conducted functional screens for genes regulated by neural activity and studied their function for vision, learning and memory.

  • Academic Appointments
    • Emeritus (Active) Professor, Neurobiology
    Research Interest

    The biochemistry and molecular genetics of growth and differentiation of nerve cells. The structure, biosynthesis and mechanism of action of nerve growth factor and other neurotrophins. Gene regulation in target organs and glial cells during nerve regeneration. The role of apolipoproteins and of the myelin protein PMP-22 during nerve degeneration and regeneration and in peripheral neuropathies.

  • Academic Appointments
    • Emeritus Faculty, Acad Council, Neurobiology

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