Ricardo Dolmetsch

Honors and Awards

• Society for Neuroscience Young Investigator Award, Society for Neuroscience (2007)
• NIH Pioneer Award, National Institutes of Health (2008-2013)
• Searle Scholar, Searle Foundation (2004-2006)
• Career Award in the Biomedical Sciences, Burroughes Welcome Fund (2002-2007)
• McKnight Scholar, McKnight Endowment for Neurosciences (2004-2006)

Professional Education

Postdoctoral Advisees

Sergiu Pasca , Thomas Portmann , Oleksandr Shcheglovitov , Masayuki Yazawa

Graduate & Fellowship Program Affiliations

• Chemical and Systems Biology
• Neurosciences

Web Site Links

• Lab Web Site

Current Research Interests

Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders. We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain.

Publications

• PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. Tsuruta F, Green EM, Rousset M, Dolmetsch RE. J Cell Biol. 2009; 187 (2): 279-94
• Induction of protein-protein interactions in live cells using light. Yazawa M, Sadaghiani AM, Hsueh B, Dolmetsch RE. Nat Biotechnol. 2009; 27 (10): 941-5
• STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Mullins FM, Park CY, Dolmetsch RE, Lewis RS. Proc Natl Acad Sci U S A. 2009; 106 (36): 15495-500
• STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS. Cell. 2009; 136 (5): 876-90
• The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2. Green EM, Barrett CF, Bultynck G, Shamah SM, Dolmetsch RE. Neuron. 2007; 55 (4): 615-32