Alan C. Pao

Clinical Focus

• Nephrology
• Nephrolithiasis

Honors and Awards

• Normon S. Coplon Extramural Grant, Satellite Healthcare (2008)
• Nephrology Junior Faculty Research Support Award, Amgen (2008)
• Mentored Clinical Scientist Award, NIH/NIDDK (2006)

Professional Education

Postdoctoral Advisees

Paru Kathpalia , Madhumitha Rajagopal , Sheela Thomas

Graduate & Fellowship Program Affiliations

• Medicine

Research Interests

We are interested in the hormonal and signal transduction pathways that control epithelial ion transport. Our model system involves tight epithelia, typically found in the distal nephron of the kidney. Clinical implications of our work include a better understanding of the pathogenesis of salt-sensitive hypertension and hypertension associated with the insulin resistance syndrome.

Publications

• Melamine nephrotoxicity: an emerging epidemic in an era of globalization. Bhalla V, Grimm PC, Chertow GM, Pao AC. Kidney Int. 2009; 75 (8): 774-9
• NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions. Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. Am J Physiol Renal Physiol. 2007; 292 (6): F1741-50
• Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. Am J Physiol Renal Physiol. 2006; 291 (4): F714-21
• SGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption. McCormick JA, Bhalla V, Pao AC, Pearce D. Physiology (Bethesda). 2005: 20 134-9
• Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Bhalla V, Daidié D, Li H, Pao AC, LaGrange LP, Wang J, Vandewalle A, Stockand JD, Staub O, Pearce D. Mol Endocrinol. 2005; 19 (12): 3073-84