Publications
-
Genomic analysis of reactive astrogliosis.
Zamanian JL,
Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA.
J Neurosci.
2012;
32
(18):
6391-410
-
Neuroprotection from stroke in the absence of MHCI or PirB.
Adelson JD,
Barreto GE, Xu L, Kim T, Brott BK, Ouyang YB, Naserke T, Djurisic M, Xiong X, Shatz CJ, Giffard RG.
Neuron.
2012;
73
(6):
1100-7
-
miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo.
Ouyang YB,
Lu Y, Yue S, Xu LJ, Xiong XX, White RE, Sun X, Giffard RG.
Neurobiol Dis.
2012;
45
(1):
555-63
-
Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia.
Xu L,
Emery JF, Ouyang YB, Voloboueva LA, Giffard RG.
Glia.
2010;
58
(9):
1042-9
-
Mitochondrial protection attenuates inflammation-induced impairment of neurogenesis in vitro and in vivo.
Voloboueva LA,
Lee SW, Emery JF, Palmer TD, Giffard RG.
J Neurosci.
2010;
30
(37):
12242-51
-
Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin.
Voloboueva LA,
Emery JF, Sun X, Giffard RG.
FEBS Lett.
2013;
587
(6):
756-62
-
Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation.
Xiong X,
White RE, Xu L, Yang L, Sun X, Zou B, Pascual C, Sakurai T, Giffard RG, Xie XS.
Stroke.
2013;
44
(3):
764-70
-
Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice.
Sun X,
Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG.
J Neurosci Res.
2013;
91
(6):
799-807
-
ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer.
Ouyang YB,
Giffard RG.
Int J Cell Biol.
2012:
2012
493934
-
Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse.
Barreto GE,
White RE, Xu L, Palm CJ, Giffard RG.
Exp Neurol.
2012;
238
(2):
284-96
-
MicroRNA-320 induces neurite outgrowth by targeting ARPP-19.
White RE,
Giffard RG.
Neuroreport.
2012;
23
(10):
590-5
-
miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.
Ouyang YB,
Lu Y, Yue S, Giffard RG.
Mitochondrion.
2012;
12
(2):
213-9
-
Astrocyte proliferation following stroke in the mouse depends on distance from the infarct.
Barreto GE,
Sun X, Xu L, Giffard RG.
PLoS One.
2011;
6
(11):
e27881
-
Astrocytes: targets for neuroprotection in stroke.
Barreto G,
White RE, Ouyang Y, Xu L, Giffard RG.
Cent Nerv Syst Agents Med Chem.
2011;
11
(2):
164-73
-
Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice.
Vizcaychipi MP,
Xu L, Barreto GE, Ma D, Maze M, Giffard RG.
Anesthesiology.
2011;
114
(4):
891-900
-
Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia.
Xiong X,
Barreto GE, Xu L, Ouyang YB, Xie X, Giffard RG.
Stroke.
2011;
42
(7):
2026-32
-
Inflammation, mitochondria, and the inhibition of adult neurogenesis.
Voloboueva LA,
Giffard RG.
J Neurosci Res.
2011;
89
(12):
1989-96
-
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress.
Ouyang YB,
Xu LJ, Emery JF, Lee AS, Giffard RG.
Mitochondrion.
2011;
11
(2):
279-86
-
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
Tang XN,
Zheng Z, Giffard RG, Yenari MA.
Ann Neurol.
2011;
70
(4):
606-15
-
Age-related defects in sensorimotor activity, spatial learning, and memory in C57BL/6 mice.
Barreto G,
Huang TT, Giffard RG.
J Neurosurg Anesthesiol.
2010;
22
(3):
214-9
-
Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia.
Webster CM,
Kelly S, Koike MA, Chock VY, Giffard RG, Yenari MA.
Neurobiol Dis.
2009;
33
(2):
301-12
-
Overexpression of mitochondrial Hsp70/Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia.
Xu L,
Voloboueva LA, Ouyang Y, Emery JF, Giffard RG.
J Cereb Blood Flow Metab.
2009;
29
(2):
365-74
-
Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor.
Han RQ,
Ouyang YB, Xu L, Agrawal R, Patterson AJ, Giffard RG.
Anesth Analg.
2009;
108
(1):
280-7
-
Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro.
Voloboueva LA,
Duan M, Ouyang Y, Emery JF, Stoy C, Giffard RG.
J Cereb Blood Flow Metab.
2008;
28
(5):
1009-16
-
Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70.
Giffard RG,
Han RQ, Emery JF, Duan M, Pittet JF.
Anesthesiology.
2008;
109
(2):
339-48
-
Inhibition of mitochondrial function in astrocytes: implications for neuroprotection.
Voloboueva LA,
Suh SW, Swanson RA, Giffard RG.
J Neurochem.
2007;
102
(4):
1383-94
-
NOx and ADMA changes with focal ischemia, amelioration with the chaperonin GroEL.
Xu L,
Wang B, Kaur K, Kho MF, Cooke JP, Giffard RG.
Neurosci Lett.
2007;
418
(2):
201-4
-
Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia.
Ouyang YB,
Voloboueva LA, Xu LJ, Giffard RG.
J Neurosci.
2007;
27
(16):
4253-60
-
Antegrade cerebral perfusion reduces apoptotic neuronal injury in a neonatal piglet model of cardiopulmonary bypass.
Chock VY,
Amir G, Davis CR, Ramamoorthy C, Riemer RK, Ray D, Giffard RG, Reddy VM.
J Thorac Cardiovasc Surg.
2006;
131
(3):
659-65
-
Biphasic role of nuclear factor-kappa B on cell survival and COX-2 expression in SOD1 Tg astrocytes after oxygen glucose deprivation.
Lee YS,
Song YS, Giffard RG, Chan PH.
J Cereb Blood Flow Metab.
2006;
26
(8):
1076-88
-
Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro.
Xu L,
Dayal M, Ouyang YB, Sun Y, Yang CF, Frydman J, Giffard RG.
Neurobiol Aging.
2006;
27
(4):
562-9
-
Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro.
Yenari MA,
Xu L, Tang XN, Qiao Y, Giffard RG.
Stroke.
2006;
37
(4):
1087-93
-
Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress.
Ouyang YB,
Xu LJ, Sun YJ, Giffard RG.
Cell Stress Chaperones.
2006;
11
(2):
180-6
-
Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex.
Lee YS,
Ouyang YB, Giffard RG.
FEBS Lett.
2006;
580
(20):
4865-71
-
The carboxyl-terminal domain of inducible Hsp70 protects from ischemic injury in vivo and in vitro.
Sun Y,
Ouyang YB, Xu L, Chow AM, Anderson R, Hecker JG, Giffard RG.
J Cereb Blood Flow Metab.
2006;
26
(7):
937-50
-
Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection.
Yenari MA,
Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG.
Ann N Y Acad Sci.
2005:
1053
74-83
-
Development of neonatal murine microglia in vitro: changes in response to lipopolysaccharide and ischemia-like injury.
Chock VY,
Giffard RG.
Pediatr Res.
2005;
57
(4):
475-80
-
Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation.
Ouyang YB,
Xu L, Giffard RG.
Neurosci Lett.
2005;
380
(3):
229-33
-
Ischemia-induced programmed cell death in astrocytes.
Giffard RG,
Swanson RA.
Glia.
2005;
50
(4):
299-306
-
Overexpression of copper/zinc superoxide dismutase decreases ischemia-like astrocyte injury.
Wang J,
Ma JH, Giffard RG.
Free Radic Biol Med.
2005;
38
(8):
1112-8
-
Cellular neuroprotective mechanisms in cerebral ischemia: Bcl-2 family proteins and protection of mitochondrial function.
Ouyang YB,
Giffard RG.
Cell Calcium.
2004 Sep-Oct;
36
(3-4):
303-11
-
Changes in astrocyte mitochondrial function with stress: effects of Bcl-2 family proteins.
Ouyang YB,
Giffard RG.
Neurochem Int.
2004 Jul-Aug;
45
(2-3):
371-9
-
Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury.
Kim JH,
Yenari MA, Giffard RG, Cho SW, Park KA, Lee JE.
Exp Neurol.
2004;
189
(1):
122-30
-
Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury.
Wang J,
Bright R, Mochly-Rosen D, Giffard RG.
Neuropharmacology.
2004;
47
(1):
136-45
-
Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.
Giffard RG,
Xu L, Zhao H, Carrico W, Ouyang Y, Qiao Y, Sapolsky R, Steinberg G, Hu B, Yenari MA.
J Exp Biol.
2004;
207
(Pt 18):
3213-20
-
Effect of overexpression of protective genes on mitochondrial function of stressed astrocytes.
Giffard R,
Ouyang Y.
J Bioenerg Biomembr.
2004;
36
(4):
313-5
-
Many mechanisms for hsp70 protection from cerebral ischemia.
Giffard RG,
Yenari MA.
J Neurosurg Anesthesiol.
2004;
16
(1):
53-61
-
Susceptibility to apoptosis varies with time in culture for murine neurons and astrocytes: changes in gene expression and activity.
Xu L,
Chock VY, Yang EY, Giffard RG.
Neurol Res.
2004;
26
(6):
632-43
-
The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytes.
Lee JE,
Kim YJ, Kim JY, Lee WT, Yenari MA, Giffard RG.
Neuroreport.
2004;
15
(3):
499-502
-
Bcl-XL maintains mitochondrial function in murine astrocytes deprived of glucose.
Ouyang YB,
Giffard RG.
J Cereb Blood Flow Metab.
2003;
23
(3):
275-9
-
Geldanamycin reduces necrotic and apoptotic injury due to oxygen-glucose deprivation in astrocytes.
Xu L,
Ouyang YB, Giffard RG.
Neurol Res.
2003;
25
(7):
697-700
-
Gene therapy and hypothermia for stroke treatment.
Yenari MA,
Zhao H, Giffard RG, Sobel RA, Sapolsky RM, Steinberg GK.
Ann N Y Acad Sci.
2003:
993
54-68; discussion 79-81
-
Overexpression of HDJ-2 protects astrocytes from ischemia-like injury and reduces redistribution of ubiquitin staining in vitro.
Qiao Y,
Ouyang YB, Giffard RG.
J Cereb Blood Flow Metab.
2003;
23
(10):
1113-6
-
Perinatal brain injury: the role of development in vulnerability.
Giffard RG,
Fiskum G.
Anesthesiology.
2003;
98
(5):
1039-41
-
Two variants of the rat brain sodium-driven chloride bicarbonate exchanger (NCBE): developmental expression and addition of a PDZ motif.
Giffard RG,
Lee YS, Ouyang YB, Murphy SL, Monyer H.
Eur J Neurosci.
2003;
18
(11):
2935-45
-
Advances in understanding protection from cerebral ischemia.
Giffard RG,
Jaffe RA.
Curr Opin Anaesthesiol.
2002;
15
(5):
495-500
-
Caspase inhibitors reduce the apoptotic but not necrotic component of kainate injury in primary murine cortical neuronal cultures.
Glassford A,
Lee JE, Xu L, Giffard RG.
Neurol Res.
2002;
24
(8):
796-800
-
Effect of Bcl-x(L) overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes.
Ouyang YB,
Carriedo SG, Giffard RG.
Free Radic Biol Med.
2002;
33
(4):
544-51
-
Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.
Kelly S,
Zhang ZJ, Zhao H, Xu L, Giffard RG, Sapolsky RM, Yenari MA, Steinberg GK.
Ann Neurol.
2002;
52
(2):
160-7
-
Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation.
Han HS,
Qiao Y, Karabiyikoglu M, Giffard RG, Yenari MA.
J Neurosci.
2002;
22
(10):
3921-8
-
Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade.
Xu L,
Yenari MA, Steinberg GK, Giffard RG.
J Cereb Blood Flow Metab.
2002;
22
(1):
21-8
-
Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage.
Howard S,
Bottino C, Brooke S, Cheng E, Giffard RG, Sapolsky R.
J Neurochem.
2002;
83
(4):
914-23
-
UV-vulnerability of human papilloma virus type-16 E7-expressing astrocytes is associated with mitochondrial membrane depolarization and caspase-3 activation.
Lee WT,
Lee SH, Carriedo SG, Giffard RG, Yoon YJ, Kim JH, Park KA, Lee JE.
Mol Cells.
2002;
14
(2):
288-94
-
Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.
Lee JE,
Yenari MA, Sun GH, Xu L, Emond MR, Cheng D, Steinberg GK, Giffard RG.
Exp Neurol.
2001;
170
(1):
129-39
-
Differential sensitivity of murine astrocytes and neurons from different brain regions to injury.
Xu L,
Sapolsky RM, Giffard RG.
Exp Neurol.
2001;
169
(2):
416-24
-
Human papilloma virus type 16 E7 genes protect astrocytes against apoptotic and necrotic death induced by hydrogen peroxide.
Lee WT,
Lee JE, Lee SH, Jang HS, Giffard RG, Park KA.
Yonsei Med J.
2001;
42
(5):
471-9
-
Ischemic vulnerability of primary murine microglial cultures.
Yenari MA,
Giffard RG.
Neurosci Lett.
2001;
298
(1):
5-8
-
Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage.
Hoehn B,
Ringer TM, Xu L, Giffard RG, Sapolsky RM, Steinberg GK, Yenari MA.
J Cereb Blood Flow Metab.
2001;
21
(11):
1303-9
-
Cell death in the central nervous system: therapeutic possibilities?
Giffard RG,
Morgan RL.
Reg Anesth Pain Med.
2000 Jan-Feb;
25
(1):
22-5
-
An introduction to the changes in gene expression that occur after cerebral ischaemia.
Papadopoulos MC,
Giffard RG, Bell BA.
Br J Neurosurg.
2000;
14
(4):
305-12
-
Principles of gene therapy: potential applications in the treatment of cerebral ischaemia.
Papadopoulos MC,
Giffard RG, Bell BA.
Br J Neurosurg.
2000;
14
(5):
407-14
-
The electrogenic sodium bicarbonate cotransporter: developmental expression in rat brain and possible role in acid vulnerability.
Giffard RG,
Papadopoulos MC, van Hooft JA, Xu L, Giuffrida R, Monyer H.
J Neurosci.
2000;
20
(3):
1001-8
-
Overexpression of bcl-2, bcl-XL or hsp70 in murine cortical astrocytes reduces injury of co-cultured neurons.
Xu L,
Lee JE, Giffard RG.
Neurosci Lett.
1999;
277
(3):
193-7
-
Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels.
Xu L,
Koumenis IL, Tilly JL, Giffard RG.
Anesthesiology.
1999;
91
(4):
1036-46
-
The neuroprotective potential of heat shock protein 70 (HSP70).
Yenari MA,
Giffard RG, Sapolsky RM, Steinberg GK.
Mol Med Today.
1999;
5
(12):
525-31
-
Acidosis reduces neuronal apoptosis.
Xu L,
Glassford AJ, Giaccia AJ, Giffard RG.
Neuroreport.
1998;
9
(5):
875-9
-
Increasing vulnerability of astrocytes to oxidative injury with age despite constant antioxidant defenses.
Papadopoulos MC,
Koumenis IL, Yuan TY, Giffard RG.
Neuroscience.
1998;
82
(3):
915-25
-
Potentiation of murine astrocyte antioxidant defence by bcl-2: protection in part reflects elevated glutathione levels.
Papadopoulos MC,
Koumenis IL, Xu L, Giffard RG.
Eur J Neurosci.
1998;
10
(4):
1252-60
-
The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury.
Lee JE,
Kim CY, Giaccia AJ, Giffard RG.
Brain Res.
1998;
795
(1-2):
10-6
-
Two tips for users of Bullard Intubating Laryngoscope.
Habibi A,
Bushell E, Jaffe RA, Giffard RG, Brock-Utne JG.
Anesth Analg.
1998;
87
(5):
1206-8
-
HSP70 protects murine astrocytes from glucose deprivation injury.
Xu L,
Giffard RG.
Neurosci Lett.
1997;
224
(1):
9-12
-
Increased production of extracellular glutamate by the mitochondrial glutaminase following neuronal death.
Newcomb R,
Sun X, Taylor L, Curthoys N, Giffard RG.
J Biol Chem.
1997;
272
(17):
11276-82
-
Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions.
Kim CY,
Tsai MH, Osmanian C, Graeber TG, Lee JE, Giffard RG, DiPaolo JA, Peehl DM, Giaccia AJ.
Cancer Res.
1997;
57
(19):
4200-4
-
Vulnerability to glucose deprivation injury correlates with glutathione levels in astrocytes.
Papadopoulos MC,
Koumenis IL, Dugan LL, Giffard RG.
Brain Res.
1997;
748
(1-2):
151-6
-
Mechanism of heat shock protein 72 induction in primary cultured astrocytes after oxygen-glucose deprivation.
Bergeron M,
Mivechi NF, Giaccia AJ, Giffard RG.
Neurol Res.
1996;
18
(1):
64-72
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Over-expression of HSP-70 protects astrocytes from combined oxygen-glucose deprivation.
Papadopoulos MC,
Sun XY, Cao J, Mivechi NF, Giffard RG.
Neuroreport.
1996;
7
(2):
429-32
-
Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration.
Bruno V,
Battaglia G, Copani A, Giffard RG, Raciti G, Raffaele R, Shinozaki H, Nicoletti F.
Eur J Neurosci.
1995;
7
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1906-13
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Correlation of CGS 19755 neuroprotection against in vitro excitotoxicity and focal cerebral ischemia.
Pérez-Pinzón MA,
Maier CM, Yoon EJ, Sun GH, Giffard RG, Steinberg GK.
J Cereb Blood Flow Metab.
1995;
15
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865-76
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Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity.
Dugan LL,
Bruno VM, Amagasu SM, Giffard RG.
J Neurosci.
1995;
15
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4545-55
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Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies.
Maier CM,
Sun GH, Kunis DM, Giffard RG, Steinberg GK.
J Neurochem.
1995;
65
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652-9
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Ultrastructure of excitotoxic neuronal death in murine cortical culture.
Regan RF,
Panter SS, Witz A, Tilly JL, Giffard RG.
Brain Res.
1995;
705
(1-2):
188-98
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Neuroprotective effect of hypothermia in cortical cultures exposed to oxygen-glucose deprivation or excitatory amino acids.
Bruno VM,
Goldberg MP, Dugan LL, Giffard RG, Choi DW.
J Neurochem.
1994;
63
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1398-406
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Neuroprotective effects of glutamate antagonists and extracellular acidity.
Kaku DA,
Giffard RG, Choi DW.
Science.
1993;
260
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Secobarbital attenuates excitotoxicity but potentiates oxygen-glucose deprivation neuronal injury in cortical cell culture.
Giffard RG,
Weiss JH, Swanson RA, Choi DW.
J Cereb Blood Flow Metab.
1993;
13
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803-10
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Extracellular alkalinity exacerbates injury of cultured cortical neurons.
Giffard RG,
Weiss JH, Choi DW.
Stroke.
1992;
23
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1817-21
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Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin.
Monyer H,
Giffard RG, Hartley DM, Dugan LL, Goldberg MP, Choi DW.
Neuron.
1992;
8
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967-73
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Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures.
Giffard RG,
Monyer H, Christine CW, Choi DW.
Brain Res.
1990;
506
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Acute brain injury, NMDA receptors, and hydrogen ions: observations in cortical cell cultures.
Choi DW,
Monyer H, Giffard RG, Goldberg MP, Christine CW.
Adv Exp Med Biol.
1990:
268
501-4
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Selective vulnerability of cultured cortical glia to injury by extracellular acidosis.
Giffard RG,
Monyer H, Choi DW.
Brain Res.
1990;
530
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138-41
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Neuronal calcium channels.
Giffard RG,
Choi DW.
J Neurosurg Anesthesiol.
1989;
1
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364-7
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Ca2+-dependent binding of severin to actin: a one-to-one complex is formed.
Giffard RG,
Weeds AG, Spudich JA.
J Cell Biol.
1984;
98
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1796-803
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Ca2+-sensitive isolation of a cortical actin matrix from Dictyostelium amoebae.
Giffard RG,
Spudich JA, Spudich A.
J Muscle Res Cell Motil.
1983;
4
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115-31
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