MIPS Molecular Imaging Program at Stanford

Dean W. Felsher

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Publication Details

  • Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis.

    Beer S, Komatsubara K, Bellovin DI, Kurobe M, Sylvester K, Felsher DW. PLoS One. 2008; 3 (6): e2493

    Overexpression of the human c-MYC (MYC) oncogene is one of the most frequently implicated events in the pathogenesis of hepatocellular carcinoma (HCC). Previously, we have shown in a conditional transgenic mouse model that MYC overexpression is restrained from inducing mitotic cellular division and tumorigenesis in the adult liver; whereas, in marked contrast, MYC induces robust proliferation associated with the very rapid onset of tumorigenesis in embryonic and neonatal mice.

    PubMedID: 18560566

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