Frederick T. Chin, Ph.D.

Publication Details

• 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alphavbeta3 integrin expression.

  Wu Z, Li ZB, Cai W, He L, Chin FT, Li F, Chen X. Eur J Nucl Med Mol Imaging. 2007; 34 (11): 1823-31

  We have previously reported that (18)F-FB-E[c(RGDyK)](2) ((18)F-FRGD2) allows quantitative PET imaging of integrin alpha(v)beta(3) expression. However, the potential clinical translation was hampered by the relatively low radiochemical yield. The goal of this study was to improve the radiolabeling yield, without compromising the tumor targeting efficiency and in vivo kinetics, by incorporating a hydrophilic bifunctional mini-PEG spacer.

  PubMedID: 17492285