Sanjiv Sam Gambhir, MD, PhD

Publication Details

• ROC and localization ROC analyses of lesion detection in whole-body FDG PET: effects of acquisition mode, attenuation correction and reconstruction algorithm.

  Farquhar TH, Llacer J, Hoh CK, Czernin J, Gambhir SS, Seltzer MA, Silverman DH, Qi J, Hsu C, Hoffman EJ. J Nucl Med. 1999; 40 (12): 2043-52

  Receiver operating characteristic (ROC) and localization ROC (LROC) studies were performed to compare lesion detection at the borderline of detectability on images reconstructed with two-dimensional filtered backprojection (FBP) without attenuation correction (a common clinical protocol), three-dimensional FBP without attenuation correction, two-dimensional FBP with segmented attenuation correction and a two-dimensional iterative maximum a posteriori (MAP) algorithm using attenuation correction. Lung cancer was the model for the study because of the prominent role of 18F-fluorodeoxyglucose PET in the staging of lung cancer and the importance of lesion detection for staging.

  PubMedID: 10616885