MIPS Molecular Imaging Program at Stanford

Michelle L. James

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Publication Details

  • 11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation.

    Boutin H, Chauveau F, Thominiaux C, Grégoire MC, James ML, Trebossen R, Hantraye P, Dollé F, Tavitian B, Kassiou M. J Nucl Med. 2007; 48 (4): 573-81

    The induction of neuroinflammatory processes, characterized by upregulation of the peripheral benzodiazepine receptor (PBR) expressed by microglial cells, is well correlated with neurodegenerative diseases and with acute neuronal loss. The continually increasing incidence of neurodegenerative diseases in developed countries has become a major health problem, for which the development of diagnostic and follow-up tools is required. Here we investigated a new PBR ligand suitable for PET to monitor neuroinflammatory processes as an indirect hallmark of neurodegeneration.

    PubMedID: 17401094

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