Xiaoyuan (Shawn) Chen

Publication Details

• PET of EGFR antibody distribution in head and neck squamous cell carcinoma models.

  Niu G, Li Z, Xie J, Le QT, Chen X. J Nucl Med. 2009; 50 (7): 1116-23

  Epidermal growth factor receptor (EGFR) is a well-characterized protooncogene that has been shown to promote tumor progression in solid cancers. Clinical results for EGFR targeting with specific monoclonal antibodies (mAbs) such as cetuximab and panitumumab are promising; however, most studies indicate that only a subgroup of patients receiving the mAbs benefit from the immunotherapy, independent of EGFR expression level. To understand the in vivo kinetics of antibody delivery and localization, we performed small-animal PET studies with (64)Cu-labeled panitumumab in xenografts derived from 3 cell lines of human head and neck squamous cell carcinoma (HNSCC).

  PubMedID: 19525473