MIPS Molecular Imaging Program at Stanford

Xiaoyuan (Shawn) Chen

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Publication Details

  • Synthesis of (4-[18F]fluorophenyl)triphenylphosphonium as a potential imaging agent for mitochondrial dysfunction.

    Cheng Z, Subbarayan M, Chen X, Gambhir SS. Journal of Labelled Compounds & Radiopharmaceuticals. 2005; 48 (2): 131-137

    Tetraphenylphosphonium (TPP) cation is able to function as a mol. probe for monitoring mitochondrial disease. The F-18 labeled TPP, (4-[18F]fluorophenyl)triphenylphosphonium (18FTPP), was therefore developed as a PET radioligand for in vivo mol. imaging of mitochondrial dysfunction. 18FTPP was synthesized via direct nucleophilic substitution of no-carrier-added [18F]fluoride with the precursor 4-nitrophenyltriphenylphosphonium. After purifn. by HPLC, the av. radiochem. yield was detd. to be 10-15% and the specific activity was >500 Ci/mmol at the end of synthesis. The total synthesis time was within 60 min, and the radiochem. purity of the 18FTPP was above 95%.

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