MIPS Molecular Imaging Program at Stanford

Helen M. Blau

Back to Profile

Publication Details

  • Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions.

    Koshy AA, Fouts AE, Lodoen MB, Alkan O, Blau HM, Boothroyd JC. Nat Methods. 2010; 7 (4): 307-9

    We describe a Toxoplasma gondii strain that will permit the use of site-specific recombination to study the host-parasite interactions of this organism. This Toxoplasma strain efficiently injects a Cre fusion protein into host cells. In a Cre-reporter cell line, a single parasite invasion induced Cre-mediated recombination in 95% of infected host cells. By infecting Cre-reporter mice with these parasites, we also monitored host-cell infection in vivo.

    PubMedID: 20208532

Stanford Medicine Resources:

Footer Links: