MIPS Molecular Imaging Program at Stanford

Alan M. Krensky, M.D.

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Publication Details

  • LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation.

    Krensky AM, Robbins E, Springer TA, Burakoff SJ. J Immunol. 1984; 132 (5): 2180-2

    Three cell surface antigens associated with the CTL-target cell interaction were previously identified by generation of mAb against OKT4+, HLA-DR-specific CTL, and selection for inhibition of cytolysis in a 51Cr-release assay. In this report, we showed that these mAb inhibit cytolysis by blocking CTL-target cell conjugate formation. It appears that LFA-1, LFA-2, and LFA-3 are cell surface structures involved in strengthening effector-target adhesion that accompanies antigen-specific recognition.

    PubMedID: 6201533

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