Alan M. Krensky, M.D.

Publication Details

• Function and cell distribution of KC-1, a novel natural killer cell-associated antigen.

  Clayberger C, Dyer B, McIntyre B, Koller TD, Hardy B, Parham P, Lanier LL, Krensky AM. J Immunol. 1986; 136 (5): 1537-41

  Natural killer (NK) cell have been implicated in immune responses to tumor and viral antigens. We describe here a monoclonal antibody, anti-KC-1, that blocks lysis of NK targets by fresh but not activated NK cells. Anti-KC-1 has no effect on cytotoxic T lymphocyte activity or on antibody-dependent cellular cytotoxicity. This antibody may be useful in the analysis of NK cell activation and the mechanism of lysis.

  PubMedID: 3081628