David K. Stevenson, M.D.
Publication Details
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Suppression of carbon monoxide excretion by zinc mesoporphyrin in adult Wistar rats: evidence for potent in vivo inhibition of bilirubin production.
Res Commun Chem Pathol Pharmacol. 1988; (1): 41-8
We studied the effect of zinc mesoporphyrin on the CO excretion rate (VeCO) and liver heme oxygenase activity of adult rats. A subcutaneous dose of 4 mumol/kg significantly lowered the VeCO between 4 and 12 hours after injection. The liver heme oxygenase activity of treated animals was significantly lower 12 hours after treatment. These findings demonstrate that zinc mesoporphyrin is a potent inhibitor of in vivo total bilirubin production, as measured by the VeCO.
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