Xiaoyuan (Shawn) Chen

Publication Details

• Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme.

  Veeravagu A, Liu Z, Niu G, Chen K, Jia B, Cai W, Jin C, Hsu AR, Connolly AJ, Tse V, Wang F, Chen X. Clin Cancer Res. 2008; 14 (22): 7330-9

  Abegrin is a monoclonal antibody to human integrin alphavbeta3, a cell adhesion molecule highly expressed on actively angiogenic endothelium and glioblastoma multiforme tumor cells. The purpose of this study was to evaluate the efficacy of a novel 90Y-Abegrin radioimmunotherapeutic agent in murine xenograft glioblastoma models with noninvasive in vivo molecular imaging modalities.

  PubMedID: 19010848