Sandip Biswal, MD

Publication Details

• Tetraphenylphosphonium as a novel molecular probe for imaging tumors.

  Min JJ, Biswal S, Deroose C, Gambhir SS. J Nucl Med. 2004; 45 (4): 636-43

  Mitochondrial membrane potential (DeltaPsim)-dependent enhanced uptake of phosphonium salts, including (3)H-tetraphenylphosphonium ((3)H-TPP), in tumor cells, suggests the potential use of phosphonium salts as tracers for tumor imaging. In this study, we characterize the tumor accumulation of (3)H-TPP and compare it with (18)F-FDG in cell culture and in xenograft, metastatic, and inflammation models in living animals.

  PubMedID: 15073261