Paul Wender

Publication Details

• Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma.

  Wender PA, Galliher WC, Bhat NM, Pillow TH, Bieber MM, Teng NN. Gynecol Oncol. 2012; 126 (1): 118-23

  Multidrug resistance is the major cause of failure of many chemotherapeutic agents. While resistance can arise from several factors, it is often dominated by drug efflux mediated by P-glycoprotein (P-gp), a membrane-bound polysubstrate export pump expressed at high levels in resistant cells. While co-administration of pump inhibitors and a drug could suppress efflux, this two-drug strategy has not yet advanced to therapy. We recently demonstrated that the reversible attachment of a guanidinium-rich molecular transporter, polyarginine, to a drug provides a conjugate that overcomes efflux-based resistance in cells and animals. This study is to determine whether this strategy for overcoming resistance is effective against human disease.

  PubMedID: 22484398