Martin Brown
Publication Details
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Oxygen tension measurements of tumors growing in mice.
Int J Radiat Oncol Biol Phys. 1999; (1): 171-80
Clinical studies using the Eppendorf histograph have shown that patients whose tumors have a low pO2 have worse local control after radiotherapy, and have higher metastatic rates. Because preclinical studies of methods of overcoming, or exploiting, hypoxia generally use transplanted tumors in mice, we have compared the oxygenation of mouse tumors with human tumors to determine the appropriateness of the transplanted mouse model for such preclinical studies.
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