Alan M. Krensky, M.D.

Publication Details

• Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth.

  Semple PL, Watkins M, Davids V, Krensky AM, Hanekom WA, Kaplan G, Ress S. Clin Dev Immunol. 2011: 2011 438463

  While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Guérin (BCG) protects against severe childhood tuberculosis, there is no consensus as to which components of the BCG-induced immune response mediate this protection. However, granulysin and perforin, found in the granules of cytotoxic T lymphocytes and Natural Killer (NK) cells, can kill intracellular mycobacteria and are implicated in protection against Mycobacterium tuberculosis.

  PubMedID: 21234358