MIPS Molecular Imaging Program at Stanford

Kim Butts Pauly

Publication Details

  • Isotropic diffusion-weighted and spiral-navigated interleaved EPI for routine imaging of acute stroke.

    Butts K, Pauly J, de Crespigny A, Moseley M. Magn Reson Med. 1997; 38 (5): 741-9

    An interleaved echo-planar imaging (EPI) technique is presented for the rapid acquisition of isotropic diffusion-weighted images of stroke patients. Sixteen isotropic diffusion-weighted images at three b values are acquired in less than 3 min. A spiral navigator echo is used to measure the constant and linear phase shifts across the head in both the x and y directions which result from motion during the isotropic diffusion- sensitizing gradients. The measured k-space errors are corrected during a gridding reconstruction. The gridding kernel has a constant width in kx and a variable width in ky which eliminates variable data-density ghosts. The resulting isotropic diffusion-weighted images have excellent lesion-to-normal brain contrast, very good spatial resolution, and little sensitivity to susceptibility effects in the base of the brain. Examples of diffusion-weighted images and ADC maps from several stroke patients are shown.

    PubMedID: 9358448

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