Beverly S. Mitchell, M.D.

Publication Details

• Cellular delivery of nucleoside diphosphates: a prodrug approach.

  Kang SH, Sinhababu AK, Cory JG, Mitchell BS, Thakker DR, Cho MJ. Pharm Res. 1997; 14 (6): 706-12

  This study is concerned with cellular delivery/generation of 2'-azido-2'-deoxyuridine and -deoxycytidine diphosphate (N3UDP or N3CDP), potent inhibitors of ribonucleotide reductase. It characterizes the phosphorylation steps involved in the conversion of 2'-azido-2'-deoxyuridine (N3Urd) and 2'-azido-2'-deoxycytidine (N3Cyd) to the corresponding diphosphates and explores a prodrug approach in cellular delivery of the inhibitor which circumvents the requirement of deoxynucleoside kinases.

  PubMedID: 9210185