Ricardo Dolmetsch

Publications

• In vitro human corticogenesis. Wang Y, Dolmetsch R. Neuron. 2013; 77 (3): 379-81
• Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons. Krey JF, Paşca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE. Nat Neurosci. 2013; 16 (2): 201-9
• LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR. Cell Stem Cell. 2011; 8 (3): 267-80
• MicroRNA-mediated conversion of human fibroblasts to neurons. Yoo AS, Sun AX, Li L, Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR. Nature. 2011; 476 (7359): 228-31
• The human brain in a dish: the promise of iPSC-derived neurons. Dolmetsch R, Geschwind DH. Cell. 2011; 145 (6): 831-4
• Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Paşca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Paşca AM, Cord B, Palmer TD, Chikahisa S, Nishino S, Bernstein JA, Hallmayer J, Geschwind DH, Dolmetsch RE. Nat Med. 2011; 17 (12): 1657-62
• Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Yazawa M, Hsueh B, Jia X, Pasca AM, Bernstein JA, Hallmayer J, Dolmetsch RE. Nature. 2011; 471 (7337): 230-4
• The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels. Park CY, Shcheglovitov A, Dolmetsch R. Science. 2010; 330 (6000): 101-5
• Induction of protein-protein interactions in live cells using light. Yazawa M, Sadaghiani AM, Hsueh B, Dolmetsch RE. Nat Biotechnol. 2009; 27 (10): 941-5
• PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. Tsuruta F, Green EM, Rousset M, Dolmetsch RE. J Cell Biol. 2009; 187 (2): 279-94
• STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Mullins FM, Park CY, Dolmetsch RE, Lewis RS. Proc Natl Acad Sci U S A. 2009; 106 (36): 15495-500
• STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS. Cell. 2009; 136 (5): 876-90
• Molecular mechanisms of autism: a possible role for Ca2+ signaling. Krey JF, Dolmetsch RE. Curr Opin Neurobiol. 2007; 17 (1): 112-9
• The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2. Green EM, Barrett CF, Bultynck G, Shamah SM, Dolmetsch RE. Neuron. 2007; 55 (4): 615-32
• Cell signaling. The double life of a transcription factor takes it outside the nucleus. Park CY, Dolmetsch R. Science. 2006; 314 (5796): 64-5
• The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor. Gomez-Ospina N, Tsuruta F, Barreto-Chang O, Hu L, Dolmetsch R. Cell. 2006; 127 (3): 591-606
• Calcium oscillations increase the efficiency and specificity of gene expression. Dolmetsch RE, Xu K, Lewis RS. Nature. 1998; 392 (6679): 933-6
• Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Dolmetsch RE, Lewis RS, Goodnow CC, Healy JI. Nature. 1997; 386 (6627): 855-8
• Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate is sufficient to cause cell death. Takahashi M, Obayashi M, Ishiguro T, Sato N, Niimi Y, Ozaki K, Mogushi K, Mahmut Y, Tanaka H, Tsuruta F, Dolmetsch R, Yamada M, Takahashi H, Kato T, Mori O, Eishi Y, Mizusawa H, Ishikawa K. PLoS One. 2013; 8 (3): e50121
• Modeling Timothy syndrome with iPS cells. Yazawa M, Dolmetsch RE. J Cardiovasc Transl Res. 2013; 6 (1): 1-9
• Apelin enhances directed cardiac differentiation of mouse and human embryonic stem cells. Wang IN, Wang X, Ge X, Anderson J, Ho M, Ashley E, Liu J, Butte MJ, Yazawa M, Dolmetsch RE, Quertermous T, Yang PC. PLoS One. 2012; 7 (6): e38328
• Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M. EMBO J. 2012; 31 (18): 3730-44
• Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC. Sci Transl Med. 2012; 4 (130): 130ra47
• The carboxy-terminal fragment of alpha(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells. Ishiguro T, Ishikawa K, Takahashi M, Obayashi M, Amino T, Sato N, Sakamoto M, Fujigasaki H, Tsuruta F, Dolmetsch R, Arai T, Sasaki H, Nagashima K, Kato T, Yamada M, Takahashi H, Hashizume Y, Mizusawa H. Acta Neuropathol. 2010; 119 (4): 447-64
• Using light to control signaling cascades in live neurons. Rana A, Dolmetsch RE. Curr Opin Neurobiol. 2010; 20 (5): 617-22
• Calcium imaging of cortical neurons using Fura-2 AM. Barreto-Chang OL, Dolmetsch RE. J Vis Exp. 2009; (23)
• Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Cell. 2009; 139 (2): 380-92
• Calcium channels light up. Green E, Dolmetsch RE. Nat Chem Biol. 2007; 3 (7): 369-70
• TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size. Brenner JS, Dolmetsch RE. PLoS One. 2007; 2 (8): e802
• Excitation-transcription coupling: signaling by ion channels to the nucleus. Dolmetsch R, Sci STKE. 2003; 2003 (166): PE4
• CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME. Neuron. 2002; 34 (2): 221-33
• Time-lapse imaging of a dynamic phosphorylation-dependent protein-protein interaction in mammalian cells. Spotts JM, Dolmetsch RE, Greenberg ME. Proc Natl Acad Sci U S A. 2002; 99 (23): 15142-7
• Calcium regulation of neuronal gene expression. West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, Takasu MA, Tao X, Greenberg ME. Proc Natl Acad Sci U S A. 2001; 98 (20): 11024-31
• Gene regulation mediated by calcium signals in T lymphocytes. Feske S, Giltnane J, Dolmetsch R, Staudt LM, Rao A. Nat Immunol. 2001; 2 (4): 316-24
• Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME. Science. 2001; 294 (5541): 333-9
• A fluorometric method for estimating the calcium content of internal stores. Bergling S, Dolmetsch R, Lewis RS, Keizer J. Cell Calcium. 1998; 23 (4): 251-9
• Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes. Healy JI, Dolmetsch RE, Lewis RS, Goodnow CC. Novartis Found Symp. 1998: 215 137-44; discussion 144-5, 186-90
• Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC. Immunity. 1997; 6 (4): 419-28
• Positive and negative regulation of depletion-activated calcium channels by calcium. Lewis RS, Dolmetsch RE, Zweifach A. Soc Gen Physiol Ser. 1996: 51 241-54
• Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes. Dolmetsch RE, Lewis RS. J Gen Physiol. 1994; 103 (3): 365-88