Department: Microbiology & Immunology

• Faculty (34)
• Postdocs (55)
• All

A

• 
  Amieva, Manuel R
  Academic Appointments

  • Assistant Professor, Pediatrics - Infectious Diseases
  • Assistant Professor, Microbiology & Immunology
  Clinical Focus

  • Infectious Diseases, Pediatric
  • Pediatric Infectious Disease
  Research Interest

  My laboratory studies the strategies pathogens utilize to colonize and subvert the epithelial barrier. We have focused on the epithelial junctions as a target for bacterial pathogens, since the cell-cell junctions serve as both a barrier to infection and also a major control site for epithelial function. In particular, we are interested in how the gastric pathogen Helicobater pylori may cause cancer by interfering with cell signaling at the epithelial junctions. We are also studying how variou..

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Arvin, Ann 
  Academic Appointments

  • Professor, Pediatrics - Infectious Diseases
  • Professor, Microbiology & Immunology
  • Member, Cancer Center
  Clinical Focus

  • Infectious Diseases, Pediatric
  • Pediatric Infectious Disease
  Research Interest

  Our laboratory investigates the pathogenesis of varicella zoster virus (VZV) infection, focusing on the functional roles of particular viral gene products in pathogenesis and virus-cell interactions in differentiated human cells in humans and in Scid-hu mouse models of VZV cell tropisms in vivo, and the immunobiology of VZV infections.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital

B

• 
  Blau, Helen 
  Academic Appointments

  • Professor, Microbiology & Immunology - Baxter Laboratory
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Molecular and cellular mechanisms that control muscle and neuronal growth; stem cell biology, differentiation, and tumorigenicity. Regulating stem cell fate in vitro and in vivo. Stem cell therapies. Hematopoietic and muscle stem cells. Characterizing and bioengineering stem cell niches. Nuclear reprogramming. Muscle development and disease. Drug delivery. Tracking cell behavior in vitro and in vivo. Understanding tissue degeneration and regeneration.

• 
  Bogyo, Matthew 
  Academic Appointments

  • Associate Professor, Pathology
  • Associate Professor, Microbiology & Immunology
  • Associate Professor (By courtesy), Chemical and Systems Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include: 1) Design and synthesis of novel chemical probes for each of the primary protease families. 2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii. 3) Defining the specific functional roles of proteases during the process of tumorogenesis. 4) In vivo imaging of protease activity

• 
  Boothroyd, John 
  Academic Appointments

  • Professor, Microbiology & Immunology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  We are intereseted in the interaction between the protozoan parasite Toxoplasma gondii and its mammalian host. We use a combination of molecular and genetic tools to understand how this obligate intracellular parasite can invade almost any cell it encounters, how it co-opts a host cell once inside and how it evades the immune response to produce a life-long, persistent infection.

C

• 
  Chen, Chang-Zheng 
  Academic Appointments

  • Assistant Professor, Microbiology & Immunology - Baxter Laboratory
  • Member, Cancer Center
  Research Interest

  We study the genetic networks controlled by regulatory RNAs, such as microRNAs (miRNAs), and currently focus on two complementary aspects of miRNA biology: (1) The roles of miRNAs in modulating the development, function, and pathogenesis of vertebrate immune systems and (2) the mechanisms by which these regulatory RNAs control gene expression.

• 
  Chien, Yueh-Hsiu 
  Academic Appointments

  • Professor, Microbiology & Immunology
  • Member, Cancer Center
  Research Interest

  Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.

• 
  Contag, Christopher 
  Academic Appointments

  • Associate Professor, Pediatrics - Neonatology
  • Associate Professor, Microbiology & Immunology
  • Associate Professor (By courtesy), Radiology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.

D

• 
  Davis, Mark 
  Academic Appointments

  • Professor, Microbiology & Immunology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes. Dynamics and functionality of specific T cell populations in human cancer.

F

• 
  Falkow, Stanley 
  Academic Appointments

  • Professor, Microbiology & Immunology
  • Professor, Medicine
  Research Interest

  Dr. Falkow is no longer taking students or postdoctoral fellows in his laboratory. Please contact either Denise Monack (dmonack@stanford.edu) or Manuel Amieva (amieva@stanford.edu).

G

• 
  Galli, Stephen 
  Academic Appointments

  • Professor, Pathology - Mouse Transgenic Facility
  • Professor, Microbiology & Immunology
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Pathology
  • Pathology and Laboratory Medicine
  Research Interest

  The goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Greenberg, Harry 
  Academic Appointments

  • Professor, Medicine - Gastroenterology & Hepatology
  • Professor, Microbiology & Immunology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Molecular mechanisms of pathogenesis; determinants of protective immunity; host range and tissue tropism in liver and GI tract pathogenic viruses and studies of vaccines in people.

K

• 
  Kirkegaard, Karla 
  Academic Appointments

  • Professor, Microbiology & Immunology
  Research Interest

  The biochemistry of RNA-dependent RNA polymerase function, the cell biology of the membrane rearrangements induced by positive-strand RNA virus infection of human cells, and the genetics of RNA viruses, which, with their high error rates, live at the brink of error catastrophe, are investigated in the Kirkegaard laboratory.

M

• 
  Matin, AC 
  Academic Appointments

  • Professor, Microbiology & Immunology
  • Member, Bio-X
  Research Interest

  1. Improvement of our newly discovered cancer prodrug regimen that permits noninvaisve visualization of drug activation. 2. Tracking tumors & cancer metastases using bacterial magnetite. 3. Molecular basis of bacterial planktonic and biofilm antibiotic resistance on Earth and under space microgravity; 4. Bioremediation.

• 
  McDevitt, Hugh 
  Academic Appointments

  • Emeritus (Active) Professor, Microbiology & Immunology
  • Emeritus Faculty, Acad Council, Microbiology & Immunology
  • Emeritus Faculty, Acad Council, Medicine
  Research Interest

  The structure of class II major histocompatibility complex molecules, their role in antigen presentation, and in the immune response in health and disease with emphasis on type 1 diabetes and rheumatoid arthritis; the role of lymphokines (tumor necrosis factor alpha, lymphotoxin) in autoimmunity.

• 
  Mocarski, Edward 
  Academic Appointments

  • Emeritus Faculty, Acad Council, Microbiology & Immunology
  Research Interest

  Research focusses on one of the human herpesviruses: cytomegalovirus (CMV). This virus is a major medical problem in immunocompromised individuals. The virus is very large, carrying over 200 genes. We have characterized functions involved in viral growth (regulation of gene expression, replication, genome packaging) and pathogenesis (tissue tropism, latency). Molecular genetic and biochemical approaches have been employed to dissect these functions.

• 
  Monack, Denise M
  Academic Appointments

  • Assistant Professor, Microbiology & Immunology
  Research Interest

  The primary focus of my research is to understand the genetic and molecular mechanisms of intracellular bacterial pathogenesis. We use two model systems, Salmonella typhimurium and Francisella tularensis, to study the complex host-pathogen interactions. Ultimately we would like to understand how Salmonella persists within certain hosts for years in the face of a robust immune response and how F. tularensis, a stealth invader, can cause a rapid, lethal infection.

N

• 
  Nolan, Garry 
  Academic Appointments

  • Professor, Microbiology & Immunology - Baxter Laboratory
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function. Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.

P

• 
  Parham, Peter 
  Academic Appointments

  • Professor, Structural Biology
  • Professor, Microbiology & Immunology
  • Member, Cancer Center
  Research Interest

  The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors.

• 
  Pizzo, Philip 
  Academic Appointments

  • Dean of the School of Medicine, Stanford University School of Medicine
  • Professor, Pediatrics
  • The Carl and Elizabeth Naumann Dean, Stanford University School of Medicine
  • Professor, Microbiology & Immunology
  • Member, Cancer Center
  Clinical Focus

  • Infectious Diseases, Pediatric
  • Pediatric Hematology-Oncology
  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Prober, Charles 
  Academic Appointments

  • Professor, Pediatrics - Infectious Diseases
  • Professor, Microbiology & Immunology
  Clinical Focus

  • Infectious Diseases, Pediatric
  • Pediatric Infectious Disease
  Research Interest

  My area of research interest is focused on the epidemiology, pathophysiology, prevention, and treatment of infections in children. Much of my research has focused on viral infections, especially those caused by herpes simplex virus (HSV). I have conducted a number of studies concerned with the epidemiology of HSV-2 infections in pregnant women, their partners, and neonates. Recently, I have extended these epidemiologic studies to adolescents.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital

R

• 
  Raffel, Sidney 
  Academic Appointments

  • Emeritus Faculty, Acad Council, Microbiology & Immunology
• 
  Relman, David 
  Academic Appointments

  • Professor, Medicine - Infectious Diseases
  • Professor, Microbiology & Immunology
  • Member, Cancer Center
  • Member, Bio-X
  Clinical Focus

  • Infectious Disease
  • Infectious Diseases
  Research Interest

  My investigative program focuses on human-microbe interactions and human microbial ecology, and is divided into two research areas: 1) Ecology of human indigenous microbial communities; 2) Classification of humans and non-human primates with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns.

• 
  Rosenberg, Leon T
  Academic Appointments

  • Emeritus Faculty, Acad Council, Microbiology & Immunology

S

• 
  Sarnow, Peter 
  Academic Appointments

  • Professor, Microbiology & Immunology
  Research Interest

  Our laboratory studies virus-host interactions with an emphasis microRNA-mediated gene regulation and on translational control. The mechanism by which a liver-specific microRNA regulates hepatitis C virus genome replication is under intense scrutiny. In addition, the mechanism of internal ribosome entry in certain cellular and viral mRNAs and its biological role in growth and development is being investigated.

• 
  Schneider, David 
  Academic Appointments

  • Associate Professor, Microbiology & Immunology
  Research Interest

  We study innate immunity and microbial pathogenesis. We have been studying models for a variety of bacterial infections including: Listeria, Mycobacteria, Salmonella and Streptococcus as well as some fungi, parasites and viruses.

• 
  Schoolnik, Gary 
  Academic Appointments

  • Professor, Medicine - Infectious Diseases
  • Professor, Microbiology & Immunology
  Clinical Focus

  • Infectious Disease
  • Infectious Diseases
  Research Interest

  Structure-function analysis of bacterial adhesion proteins and toxins; design and synthesis of synthetic antigens; immunobiology of human papillomaviruses

• 
  Shachaf, Catherine 
  Academic Appointments

  • Instructor, Microbiology & Immunology - Baxter Laboratory
  Research Interest

  The focus of our research is to determine the genomic and proteomic signatures of a cancer cell, and to compare them to the signatures of normal stem cells. The goal is to identify the pathway(s) that determine the fate of a progenitor cell – to become neoplastic or to remain normal – then to prevent the neoplastic pathway decision. We are also developing surface enhanced Raman (SERS) nanoparticles to supplement the fluorescent molecules currently available for flow cytometry.

• 
  Siegel, Robert 
  Academic Appointments

  • Associate Professor (Teaching), Microbiology & Immunology
  Research Interest

  My work is primarily involved in medical education and curricular development, especially in the areas of infectious disease, virology, HIV, and molecular biology. Projects included electronic applications to science education, three dimensional model building, service learning, and the development of undergraduate research projects.

• 
  Singh, Upinder 
  Academic Appointments

  • Assistant Professor, Medicine - Infectious Diseases
  • Assistant Professor, Microbiology & Immunology
  • Member, Bio-X
  Clinical Focus

  • Infectious Disease
  • Infectious Diseases
  Research Interest

  Our lab elucidates the molecular basis of pathogenesis of the protozoan parasite Entamoeba histolytica. We use genetic and genomic approaches to identify novel virulence determinants and to characterize the global epidemiology of the parasite.

• 
  Sonnenburg, Justin L
  Academic Appointments

  • Assistant Professor, Microbiology & Immunology
  • Member, Bio-X
  Research Interest

  We are interested in the basic principles that govern interactions within the intestinal microbiota and between the microbiota and the host. To pursue these aims, we colonize germ-free (gnotobiotic) mice with simplified, model microbial communities, apply systems approaches (e.g. functional genomics), and use genetic tools for the host and microbes to gain mechanistic insight into emergent properties of the host-microbial super-organism.

T

• 
  Tan, Man-Wah 
  Academic Appointments

  • Assistant Professor, Genetics
  • Assistant Professor, Microbiology & Immunology
  • Member, Bio-X
  Research Interest

  Genome-wide analysis of host-pathogen interactions using a bacteria-C. elegans pathogenesis model; molecular mechanisms of virulence of bacterial pathogens; regulation of host-pathogen interactions by fatty acids and the nervous system; elucidate the distinctions in the regulation of immunity, stress and longevity.

• 
  Theriot, Julie 
  Academic Appointments

  • Associate Professor, Biochemistry
  • Associate Professor, Microbiology & Immunology
  Research Interest

  We study the interactions between infectious bacteria and the human host cell actin cytoskeleton. Listeria monocytogenes and Shigella flexneri are unrelated food-borne bacterial pathogens that share a common mechanism of invasion and actin-dependent intercellular spread in epithelial cells. Our studies fall into three broad areas: the biochemical basis of actin-based motility by these bacteria, the biophysical mechanism of force generation, and the evolutionary origin of pathogenesis.

• 
  Tompkins, Lucy 
  Academic Appointments

  • Professor, Medicine - Infectious Diseases
  • Professor, Microbiology & Immunology
  Clinical Focus

  • Infectious Diseases
  • Internal Medicine
  • hospital epidemiology
  Research Interest

  Molecular and cellular pathogenesis of Helicobacter infection. Molecular epidemiology, hospital epidemiology.