Russ B. Altman
Publication Details
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Prediction of calcium-binding sites by combining loop-modeling with machine learning.
BMC Struct Biol. 2009: 72
Protein ligand-binding sites in the apo state exhibit structural flexibility. This flexibility often frustrates methods for structure-based recognition of these sites because it leads to the absence of electron density for these critical regions, particularly when they are in surface loops. Methods for recognizing functional sites in these missing loops would be useful for recovering additional functional information.
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