Junlei Chang
Publication Details
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Soluble guanylate cyclase alpha1beta1 limits stroke size and attenuates neurological injury.
Stroke. 2010; (8): 1815-9
Nitric oxide mediates endothelium-dependent vasodilation, modulates cerebral blood flow, and determines stroke outcome. Nitric oxide signals in part by stimulating soluble guanylate cyclase (sGC) to synthesize cGMP. To study the role of sGC in stroke injury, we compared the outcome of cerebral ischemia and reperfusion in mice deficient in the alpha(1) subunit of sGC (sGCalpha(1)(-/-)) with that in wild-type mice.
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