Jorg Goronzy

Publications

• IL-7- and IL-15-mediated TCR sensitization enables T cell responses to self-antigens. Deshpande P, Cavanagh MM, Le Saux S, Singh K, Weyand CM, Goronzy JJ. J Immunol. 2013; 190 (4): 1416-23
• The janus head of T cell aging - autoimmunity and immunodeficiency. Goronzy JJ, Li G, Yang Z, Weyand CM. Front Immunol. 2013: 4 131
• Understanding immunosenescence to improve responses to vaccines. Goronzy JJ, Weyand CM. Nat Immunol. 2013; 14 (5): 428-36
• CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells. Suzuki M, Jagger AL, Konya C, Shimojima Y, Pryshchep S, Goronzy JJ, Weyand CM. J Immunol. 2012; 189 (5): 2118-30
• Chronic inflammation and aging: DNA damage tips the balance. Cavanagh MM, Weyand CM, Goronzy JJ. Curr Opin Immunol. 2012; 24 (4): 488-93
• Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Li G, Yu M, Lee WW, Tsang M, Krishnan E, Weyand CM, Goronzy JJ. Nat Med. 2012; 18 (10): 1518-24
• Immune aging and autoimmunity. Goronzy JJ, Weyand CM. Cell Mol Life Sci. 2012; 69 (10): 1615-23
• Mechanisms of immunosenescence: lessons from models of accelerated immune aging. Le Saux S, Weyand CM, Goronzy JJ. Ann N Y Acad Sci. 2012: 1247 69-82
• Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Yu M, Li G, Lee WW, Yuan M, Cui D, Weyand CM, Goronzy JJ. Proc Natl Acad Sci U S A. 2012; 109 (15): E879-88
• Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment. Goronzy JJ, Li G, Yu M, Weyand CM. Semin Immunol. 2012; 24 (5): 365-72
• The immunopathology of giant cell arteritis: diagnostic and therapeutic implications. Weyand CM, Liao YJ, Goronzy JJ. J Neuroophthalmol. 2012; 32 (3): 259-65
• Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Piggott K, Deng J, Warrington K, Younge B, Kubo JT, Desai M, Goronzy JJ, Weyand CM. Circulation. 2011; 123 (3): 309-18
• Finding Balance: T cell Regulatory Receptor Expression during Aging. Cavanagh MM, Qi Q, Weyand CM, Goronzy JJ. Aging Dis. 2011; 2 (5): 398-413
• Giant cell arteritis: immune and vascular aging as disease risk factors. Mohan SV, Liao YJ, Kim JW, Goronzy JJ, Weyand CM. Arthritis Res Ther. 2011; 13 (4): 231
• IFN-γ and IL-17: the two faces of T-cell pathology in giant cell arteritis. Weyand CM, Younge BR, Goronzy JJ. Curr Opin Rheumatol. 2011; 23 (1): 43-9
• Magnetic resonance angiography in extracranial giant cell arteritis. Koenigkam-Santos M, Sharma P, Kalb B, Oshinski JN, Weyand CM, Goronzy JJ, Martin DR. J Clin Rheumatol. 2011; 17 (6): 306-10
• Regulation of T cell receptor signaling by activation-induced zinc influx. Yu M, Lee WW, Tomar D, Pryshchep S, Czesnikiewicz-Guzik M, Lamar DL, Li G, Singh K, Tian L, Weyand CM, Goronzy JJ. J Exp Med. 2011; 208 (4): 775-85
• Report from the second cytomegalovirus and immunosenescence workshop. Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, Colonna-Romano G, Dutta A, Franceschi C, Fulop T, Gkrania-Klotsas E, Goronzy J, Griffiths SJ, Henson S, Herndler-Brandstetter D, Hill A, Kern F, Klenerman P, Macallan D, Macualay R, Maier AB, Mason G, Melzer D, Morgan M, Moss P, Nikolich-Zugich J, Pachnio A, Riddell N, Roberts R, Sansoni P, Sauce D, Sinclair J, Solana R, Strindhall J, Trzonkowski P, van Lier R, Vescovini R, Wang G, Westendorp R, Pawelec G. Immun Ageing. 2011; 8 (1): 10
• Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation. Chen W, Li L, Brod T, Saeed O, Thabet S, Jansen T, Dikalov S, Weyand C, Goronzy J, Harrison DG. J Biol Chem. 2011; 286 (16): 13846-51
• Telomere dysfunction, autoimmunity and aging. Hohensinner PJ, Goronzy JJ, Weyand CM. Aging Dis. 2011; 2 (6): 524-37
• DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. Shao L, Goronzy JJ, Weyand CM. EMBO Mol Med. 2010; 2 (10): 415-27
• Immune aging and rheumatoid arthritis. Goronzy JJ, Shao L, Weyand CM. Rheum Dis Clin North Am. 2010; 36 (2): 297-310
• Immune senescence. Aspinall R, Goronzy JJ. Curr Opin Immunol. 2010; 22 (4): 497-9
• Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Vinh A, Chen W, Blinder Y, Weiss D, Taylor WR, Goronzy JJ, Weyand CM, Harrison DG, Guzik TJ. Circulation. 2010; 122 (24): 2529-37
• Insufficient deactivation of the protein tyrosine kinase lck amplifies T-cell responsiveness in acute coronary syndrome. Pryshchep S, Goronzy JJ, Parashar S, Weyand CM. Circ Res. 2010; 106 (4): 769-78
• Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages. Lamar DL, Weyand CM, Goronzy JJ. Blood. 2010; 115 (16): 3278-86
• Telomeres and immunological diseases of aging. Andrews NP, Fujii H, Goronzy JJ, Weyand CM. Gerontology. 2010; 56 (4): 390-403
• Th17 and Th1 T-cell responses in giant cell arteritis. Deng J, Younge BR, Olshen RA, Goronzy JJ, Weyand CM. Circulation. 2010; 121 (7): 906-15
• Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome. Zou JX, Rollison DE, Boulware D, Chen DT, Sloand EM, Pfannes LV, Goronzy JJ, Bai F, Painter JS, Wei S, Cosgrove D, List AF, Epling-Burnette PK. Leukemia. 2009; 23 (7): 1288-96
• CD28(-) T cells: their role in the age-associated decline of immune function. Weng NP, Akbar AN, Goronzy J. Trends Immunol. 2009; 30 (7): 306-12
• Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. Shao L, Fujii H, Colmegna I, Oishi H, Goronzy JJ, Weyand CM. J Exp Med. 2009; 206 (6): 1435-49
• Developments in the scientific understanding of rheumatoid arthritis. Goronzy JJ, Weyand CM. Arthritis Res Ther. 2009; 11 (5): 249
• ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis. Singh K, Deshpande P, Pryshchep S, Colmegna I, Liarski V, Weyand CM, Goronzy JJ. J Immunol. 2009; 183 (12): 8258-67
• Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells. Li G, Yu M, Weyand CM, Goronzy JJ. Blood. 2009; 114 (16): 3422-30
• Rejuvenating the immune system in rheumatoid arthritis. Weyand CM, Fujii H, Shao L, Goronzy JJ. Nat Rev Rheumatol. 2009; 5 (10): 583-8
• Telomerase insufficiency in rheumatoid arthritis. Fujii H, Shao L, Colmegna I, Goronzy JJ, Weyand CM. Proc Natl Acad Sci U S A. 2009; 106 (11): 4360-5
• Toll-like receptors 4 and 5 induce distinct types of vasculitis. Deng J, Ma-Krupa W, Gewirtz AT, Younge BR, Goronzy JJ, Weyand CM. Circ Res. 2009; 104 (4): 488-95
• Treating autoimmune disease by targeting CD8(+) T suppressor cells. Konya C, Goronzy JJ, Weyand CM. Expert Opin Biol Ther. 2009; 9 (8): 951-65
• Vascular damage in giant cell arteritis. Piggott K, Biousse V, Newman NJ, Goronzy JJ, Weyand CM. Autoimmunity. 2009; 42 (7): 596-604
• [Pathogenesis of medium- and large-vessel vasculitis]. Weyand CM, Goronzy JJ. Z Rheumatol. 2009; 68 (2): 100-7
• Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Lee WW, Cui D, Czesnikiewicz-Guzik M, Vencio RZ, Shmulevich I, Aderem A, Weyand CM, Goronzy JJ. Rejuvenation Res. 2008; 11 (6): 1001-11
• Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Colmegna I, Diaz-Borjon A, Fujii H, Schaefer L, Goronzy JJ, Weyand CM. Arthritis Rheum. 2008; 58 (4): 990-1000
• Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells. Li G, Weyand CM, Goronzy JJ. J Leukoc Biol. 2008; 84 (3): 824-34
• Inhibitory CD8+ T cells in autoimmune disease. Suzuki M, Konya C, Goronzy JJ, Weyand CM. Hum Immunol. 2008; 69 (11): 781-9
• Is hypertension an immunologic disease? Harrison DG, Guzik TJ, Goronzy J, Weyand C. Curr Cardiol Rep. 2008; 10 (6): 464-9
• Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritis. Singh K, Colmegna I, He X, Weyand CM, Goronzy JJ. J Immunol. 2008; 180 (3): 1971-8
• T cell subset-specific susceptibility to aging. Czesnikiewicz-Guzik M, Lee WW, Cui D, Hiruma Y, Lamar DL, Yang ZZ, Ouslander JG, Weyand CM, Goronzy JJ. Clin Immunol. 2008; 127 (1): 107-18
• T cells in arteritis and atherosclerosis. Weyand CM, Younge BR, Goronzy JJ. Curr Opin Lipidol. 2008; 19 (5): 469-77
• T-cell co-stimulatory pathways in autoimmunity. Goronzy JJ, Weyand CM. Arthritis Res Ther. 2008: 10 Suppl 1 S3
• TLR-mediated induction of negative regulatory ligands on dendritic cells. Gröschel S, Piggott KD, Vaglio A, Ma-Krupa W, Singh K, Goronzy JJ, Weyand CM. J Mol Med (Berl). 2008; 86 (4): 443-55
• Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammation. Han JW, Shimada K, Ma-Krupa W, Johnson TL, Nerem RM, Goronzy JJ, Weyand CM. Circ Res. 2008; 102 (5): 546-53
• Vessel-specific Toll-like receptor profiles in human medium and large arteries. Pryshchep O, Ma-Krupa W, Younge BR, Goronzy JJ, Weyand CM. Circulation. 2008; 118 (12): 1276-84
• Aging and T-cell diversity. Goronzy JJ, Lee WW, Weyand CM. Exp Gerontol. 2007; 42 (5): 400-6
• Fractalkine mediates T cell-dependent proliferation of synovial fibroblasts in rheumatoid arthritis. Sawai H, Park YW, He X, Goronzy JJ, Weyand CM. Arthritis Rheum. 2007; 56 (10): 3215-25
• Functional profile of activated dendritic cells in unstable atherosclerotic plaque. Erbel C, Sato K, Meyer FB, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. Basic Res Cardiol. 2007; 102 (2): 123-32
• Immune-mediated mechanisms in atherosclerosis: prevention and treatment of clinical manifestations. Niessner A, Goronzy JJ, Weyand CM. Curr Pharm Des. 2007; 13 (36): 3701-10
• Occurrence of giant cell arteritis...suddenly. Younge BR, Weyand CM, Goronzy JJ. Trans Am Ophthalmol Soc. 2007: 105 141-4; discussion 144-5
• Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. Guzik TJ, Hoch NE, Brown KA, McCann LA, Rahman A, Dikalov S, Goronzy J, Weyand C, Harrison DG. J Exp Med. 2007; 204 (10): 2449-60
• Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha and Toll-like receptor 4 ligands in the atherosclerotic plaque. Niessner A, Shin MS, Pryshchep O, Goronzy JJ, Chaikof EL, Weyand CM. Circulation. 2007; 116 (18): 2043-52
• Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis. Lee WW, Yang ZZ, Li G, Weyand CM, Goronzy JJ. J Immunol. 2007; 179 (4): 2609-15
• Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis. Turesson C, Schaid DJ, Weyand CM, Jacobsson LT, Goronzy JJ, Petersson IF, Dechant SA, Nyähll-Wåhlin BM, Truedsson L, Sturfelt G, Matteson EL. Arthritis Rheum. 2006; 54 (9): 2776-83
• Immunosuppression in atherosclerosis: mobilizing the opposition within. Goronzy JJ, Weyand CM. Circulation. 2006; 114 (18): 1901-4
• Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque. Zhang X, Niessner A, Nakajima T, Ma-Krupa W, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. Circ Res. 2006; 98 (4): 524-31
• Lymphoma in rheumatoid arthritis: an immune system set up for failure. Weyand CM, Goronzy JJ, Kurtin PJ. Arthritis Rheum. 2006; 54 (3): 685-9
• Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha. Niessner A, Sato K, Chaikof EL, Colmegna I, Goronzy JJ, Weyand CM. Circulation. 2006; 114 (23): 2482-9
• Pathomechanisms in rheumatoid arthritis--time for a string theory? Weyand CM, Goronzy JJ. J Clin Invest. 2006; 116 (4): 869-71
• Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo. Niessner A, Steiner S, Speidl WS, Pleiner J, Seidinger D, Maurer G, Goronzy JJ, Weyand CM, Kopp CW, Huber K, Wolzt M, Wojta J. Atherosclerosis. 2006; 189 (2): 408-13
• T cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome. Pryshchep S, Sato K, Goronzy JJ, Weyand CM. Circ Res. 2006; 98 (9): 1168-76
• T-cell-targeted therapies in rheumatoid arthritis. Weyand CM, Goronzy JJ. Nat Clin Pract Rheumatol. 2006; 2 (4): 201-10
• TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. Sato K, Niessner A, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. J Exp Med. 2006; 203 (1): 239-50
• Telomeres, immune aging and autoimmunity. Goronzy JJ, Fujii H, Weyand CM. Exp Gerontol. 2006; 41 (3): 246-51
• Treatment of chronic inflammatory diseases with biologic agents: opportunities and risks for the elderly. Diaz-Borjon A, Weyand CM, Goronzy JJ. Exp Gerontol. 2006; 41 (12): 1250-5
• Treatment of giant cell arteritis using induction therapy with high-dose glucocorticoids: a double-blind, placebo-controlled, randomized prospective clinical trial. Mazlumzadeh M, Hunder GG, Easley KA, Calamia KT, Matteson EL, Griffing WL, Younge BR, Weyand CM, Goronzy JJ. Arthritis Rheum. 2006; 54 (10): 3310-8
• Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors. Henel G, Singh K, Cui D, Pryshchep S, Lee WW, Weyand CM, Goronzy JJ. Blood. 2006; 107 (11): 4449-57
• B cells as a therapeutic target in autoimmune diseases. Park YW, Pryshchep S, Seyler TM, Goronzy JJ, Weyand CM. Expert Opin Ther Targets. 2005; 9 (3): 431-45
• B cells in rheumatoid synovitis. Weyand CM, Seyler TM, Goronzy JJ. Arthritis Res Ther. 2005: 7 Suppl 3 S9-12
• BLyS and APRIL in rheumatoid arthritis. Seyler TM, Park YW, Takemura S, Bram RJ, Kurtin PJ, Goronzy JJ, Weyand CM. J Clin Invest. 2005; 115 (11): 3083-92
• Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritis. Davila E, Kang YM, Park YW, Sawai H, He X, Pryshchep S, Goronzy JJ, Weyand CM. J Immunol. 2005; 174 (11): 7292-301
• Costimulatory pathways in rheumatoid synovitis and T-cell senescence. Goronzy JJ, Henel G, Sawai H, Singh K, Lee EB, Pryshchep S, Weyand CM. Ann N Y Acad Sci. 2005: 1062 182-94
• Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cells. Xu J, Vallejo AN, Jiang Y, Weyand CM, Goronzy JJ. J Biol Chem. 2005; 280 (25): 24277-85
• Lipopolysaccharide, CD14 and Toll-like receptors: an emerging link between innate immunity and atherosclerotic disease. Shimada K, Daida H, Ma-Krupa W, Goronzy JJ, Weyand CM. Future Cardiol. 2005; 1 (5): 657-74
• Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis. Bryl E, Vallejo AN, Matteson EL, Witkowski JM, Weyand CM, Goronzy JJ. Arthritis Rheum. 2005; 52 (10): 2996-3003
• Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study. Warrington KJ, Kent PD, Frye RL, Lymp JF, Kopecky SL, Goronzy JJ, Weyand CM. Arthritis Res Ther. 2005; 7 (5): R984-91
• Rheumatoid arthritis. Goronzy JJ, Weyand CM. Immunol Rev. 2005: 204 55-73
• T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis. Sawai H, Park YW, Roberson J, Imai T, Goronzy JJ, Weyand CM. Arthritis Rheum. 2005; 52 (5): 1392-401
• T cell development and receptor diversity during aging. Goronzy JJ, Weyand CM. Curr Opin Immunol. 2005; 17 (5): 468-75
• The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis. Turesson C, Schaid DJ, Weyand CM, Jacobsson LT, Goronzy JJ, Petersson IF, Sturfelt G, Nyhäll-Wåhlin BM, Truedsson L, Dechant SA, Matteson EL. Arthritis Res Ther. 2005; 7 (6): R1386-93
• The influence of age on T cell generation and TCR diversity. Naylor K, Li G, Vallejo AN, Lee WW, Koetz K, Bryl E, Witkowski J, Fulbright J, Weyand CM, Goronzy JJ. J Immunol. 2005; 174 (11): 7446-52
• Tissue trafficking patterns of effector memory CD4+ T cells in rheumatoid arthritis. Zhang X, Nakajima T, Goronzy JJ, Weyand CM. Arthritis Rheum. 2005; 52 (12): 3839-49
• Toll-like receptors in giant cell arteritis. Ma-Krupa W, Kwan M, Goronzy JJ, Weyand CM. Clin Immunol. 2005; 115 (1): 38-46
• Vascular dendritic cells in giant cell arteritis. Weyand CM, Ma-Krupa W, Pryshchep O, Gröschel S, Bernardino R, Goronzy JJ. Ann N Y Acad Sci. 2005: 1062 195-208
• Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. Ma-Krupa W, Jeon MS, Spoerl S, Tedder TF, Goronzy JJ, Weyand CM. J Exp Med. 2004; 199 (2): 173-83
• Biology of T lymphocytes. Vallejo AN, Davila E, Weyand CM, Goronzy JJ. Rheum Dis Clin North Am. 2004; 30 (1): 135-57
• HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis. Takemura S, Toda Y, Goronzy JJ, Weyand CM, Ogawa R, Iida H. Mod Rheumatol. 2004; 14 (1): 37-42
• How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to 'non-aggressive' DMARD treatment and perspective from a 2-yr open label trial. Matteson EL, Weyand CM, Fulbright JW, Christianson TJ, McClelland RL, Goronzy JJ. Rheumatology (Oxford). 2004; 43 (5): 619-25
• Immunopathways in giant cell arteritis and polymyalgia rheumatica. Weyand CM, Ma-Krupa W, Goronzy JJ. Autoimmun Rev. 2004; 3 (1): 46-53
• Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis. Braun A, Takemura S, Vallejo AN, Goronzy JJ, Weyand CM. Arthritis Rheum. 2004; 50 (7): 2140-50
• Prognostic markers of radiographic progression in early rheumatoid arthritis. Goronzy JJ, Matteson EL, Fulbright JW, Warrington KJ, Chang-Miller A, Hunder GG, Mason TG, Nelson AM, Valente RM, Crowson CS, Erlich HA, Reynolds RL, Swee RG, O'Fallon WM, Weyand CM. Arthritis Rheum. 2004; 50 (1): 43-54
• Stem cell aging and autoimmunity in rheumatoid arthritis. Weyand CM, Goronzy JJ. Trends Mol Med. 2004; 10 (9): 426-33
• Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms. Snyder MR, Nakajima T, Leibson PJ, Weyand CM, Goronzy JJ. J Immunol. 2004; 173 (6): 3725-31
• T-cell regulation in rheumatoid arthritis. Goronzy JJ, Weyand CM. Curr Opin Rheumatol. 2004; 16 (3): 212-7
• T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Vallejo AN, Weyand CM, Goronzy JJ. Trends Mol Med. 2004; 10 (3): 119-24
• The double life of NK receptors: stimulation or co-stimulation? Snyder MR, Weyand CM, Goronzy JJ. Trends Immunol. 2004; 25 (1): 25-32
• Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Park YW, Kang YM, Butterfield J, Detmar M, Goronzy JJ, Weyand CM. Am J Pathol. 2004; 165 (6): 2087-98
• Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription. Lewis DE, Merched-Sauvage M, Goronzy JJ, Weyand CM, Vallejo AN. J Biol Chem. 2004; 279 (28): 29130-8
• VEGF gene polymorphisms and susceptibility to rheumatoid arthritis. Han SW, Kim GW, Seo JS, Kim SJ, Sa KH, Park JY, Lee J, Kim SY, Goronzy JJ, Weyand CM, Kang YM. Rheumatology (Oxford). 2004; 43 (9): 1173-7
• Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Goronzy JJ, Weyand CM. Arthritis Res Ther. 2003; 5 (5): 225-34
• B cells as a therapeutic target in autoimmune disease. Goronzy JJ, Weyand CM. Arthritis Res Ther. 2003; 5 (3): 131-5
• CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation. Warrington KJ, Vallejo AN, Weyand CM, Goronzy JJ. Blood. 2003; 101 (9): 3543-9
• De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. Nakajima T, Goek O, Zhang X, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. Circ Res. 2003; 93 (2): 106-13
• Ectopic germinal center formation in rheumatoid synovitis. Weyand CM, Goronzy JJ. Ann N Y Acad Sci. 2003: 987 140-9
• Giant-cell arteritis and polymyalgia rheumatica. Weyand CM, Goronzy JJ. Ann Intern Med. 2003; 139 (6): 505-15
• Homeostatic control of T-cell generation in neonates. Schönland SO, Zimmer JK, Lopez-Benitez CM, Widmann T, Ramin KD, Goronzy JJ, Weyand CM. Blood. 2003; 102 (4): 1428-34
• Immunosenescence, autoimmunity, and rheumatoid arthritis. Weyand CM, Fulbright JW, Goronzy JJ. Exp Gerontol. 2003; 38 (8): 833-41
• Medium- and large-vessel vasculitis. Weyand CM, Goronzy JJ. N Engl J Med. 2003; 349 (2): 160-9
• Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Schönland SO, Lopez C, Widmann T, Zimmer J, Bryl E, Goronzy JJ, Weyand CM. Proc Natl Acad Sci U S A. 2003; 100 (23): 13471-6
• Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. Snyder MR, Lucas M, Vivier E, Weyand CM, Goronzy JJ. J Exp Med. 2003; 197 (4): 437-49
• Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction. Vallejo AN, Yang H, Klimiuk PA, Weyand CM, Goronzy JJ. J Immunol. 2003; 171 (4): 1732-40
• The power of the third dimension: tissue architecture and autoimmunity in rheumatoid arthritis. Weyand CM, Kang YM, Kurtin PJ, Goronzy JJ. Curr Opin Rheumatol. 2003; 15 (3): 259-66
• Bi-directional modulation of T cell-dependent antibody production by prostaglandin E(2). He X, Weyand CM, Goronzy JJ, Zhong W, Stuart JM. Int Immunol. 2002; 14 (1): 69-77
• CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. Kang YM, Zhang X, Wagner UG, Yang H, Beckenbaugh RD, Kurtin PJ, Goronzy JJ, Weyand CM. J Exp Med. 2002; 195 (10): 1325-36
• Cytokines in giant-cell arteritis. Goronzy JJ, Weyand CM. Cleve Clin J Med. 2002: 69 Suppl 2 SII91-4
• Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells. Snyder MR, Muegge LO, Offord C, O'Fallon WM, Bajzer Z, Weyand CM, Goronzy JJ. J Immunol. 2002; 168 (8): 3839-46
• Molecular basis for the loss of CD28 expression in senescent T cells. Vallejo AN, Bryl E, Klarskov K, Naylor S, Weyand CM, Goronzy JJ. J Biol Chem. 2002; 277 (49): 46940-9
• Pathogenic mechanisms in giant cell arteritis. Weyand CM, Goronzy JJ. Cleve Clin J Med. 2002: 69 Suppl 2 SII28-32
• Premature immunosenescence in rheumatoid arthritis. Weyand CM, Goronzy JJ. J Rheumatol. 2002; 29 (6): 1141-6
• Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries. Borkowski A, Younge BR, Szweda L, Mock B, Björnsson J, Moeller K, Goronzy JJ, Weyand CM. Am J Pathol. 2002; 161 (1): 115-23
• T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Nakajima T, Schulte S, Warrington KJ, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. Circulation. 2002; 105 (5): 570-5
• Therapeutic effects of acetylsalicylic acid in giant cell arteritis. Weyand CM, Kaiser M, Yang H, Younge B, Goronzy JJ. Arthritis Rheum. 2002; 46 (2): 457-66
• Trapping of misdirected dendritic cells in the granulomatous lesions of giant cell arteritis. Krupa WM, Dewan M, Jeon MS, Kurtin PJ, Younge BR, Goronzy JJ, Weyand CM. Am J Pathol. 2002; 161 (5): 1815-23
• CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Warrington KJ, Takemura S, Goronzy JJ, Weyand CM. Arthritis Rheum. 2001; 44 (1): 13-20
• Down-regulation of CD28 expression by TNF-alpha. Bryl E, Vallejo AN, Weyand CM, Goronzy JJ. J Immunol. 2001; 167 (6): 3231-8
• Ectopic lymphoid organogenesis: a fast track for autoimmunity. Weyand CM, Kurtin PJ, Goronzy JJ. Am J Pathol. 2001; 159 (3): 787-93
• Functional disruption of the CD28 gene transcriptional initiator in senescent T cells. Vallejo AN, Weyand CM, Goronzy JJ. J Biol Chem. 2001; 276 (4): 2565-70
• Lymphoid microstructures in rheumatoid synovitis. Weyand CM, Braun A, Takemura S, Goronzy JJ. Curr Dir Autoimmun. 2001: 3 168-87
• Lymphoid neogenesis in rheumatoid synovitis. Takemura S, Braun A, Crowson C, Kurtin PJ, Cofield RH, O'Fallon WM, Goronzy JJ, Weyand CM. J Immunol. 2001; 167 (2): 1072-80
• Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. Yen JH, Moore BE, Nakajima T, Scholl D, Schaid DJ, Weyand CM, Goronzy JJ. J Exp Med. 2001; 193 (10): 1159-67
• Molecular fingerprint of interferon-gamma signaling in unstable angina. Liuzzo G, Vallejo AN, Kopecky SL, Frye RL, Holmes DR, Goronzy JJ, Weyand CM. Circulation. 2001; 103 (11): 1509-14
• T cell activation in rheumatoid synovium is B cell dependent. Takemura S, Klimiuk PA, Braun A, Goronzy JJ, Weyand CM. J Immunol. 2001; 167 (8): 4710-8
• T cell homeostasis and autoreactivity in rheumatoid arthritis. Goronzy JJ, Weyand CM. Curr Dir Autoimmun. 2001: 3 112-32
• T-cell immunity in acute coronary syndromes. Weyand CM, Goronzy JJ, Liuzzo G, Kopecky SL, Holmes DR, Frye RL. Mayo Clin Proc. 2001; 76 (10): 1011-20
• Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis. Goronzy JJ, Weyand CM. Trends Immunol. 2001; 22 (5): 251-5
• Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, O'Fallon WM, Weyand CM. J Virol. 2001; 75 (24): 12182-7
• Association of MHC and rheumatoid arthritis. HLA polymorphisms in phenotypic variants of rheumatoid arthritis. Weyand CM, Goronzy JJ. Arthritis Res. 2000; 2 (3): 212-6
• Cell-cell interactions in synovitis. Interactions between T cells and B cells in rheumatoid arthritis. Weyand CM, Goronzy JJ, Takemura S, Kurtin PJ. Arthritis Res. 2000; 2 (6): 457-63
• Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells. Vallejo AN, Mügge LO, Klimiuk PA, Weyand CM, Goronzy JJ. J Immunol. 2000; 164 (6): 2947-54
• Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways. Vallejo AN, Schirmer M, Weyand CM, Goronzy JJ. J Immunol. 2000; 165 (11): 6301-7
• Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis. Namekawa T, Snyder MR, Yen JH, Goehring BE, Leibson PJ, Weyand CM, Goronzy JJ. J Immunol. 2000; 165 (2): 1138-45
• Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Liuzzo G, Goronzy JJ, Yang H, Kopecky SL, Holmes DR, Frye RL, Weyand CM. Circulation. 2000; 101 (25): 2883-8
• Pathogenic principles in giant cell arteritis. Weyand CM, Goronzy JJ. Int J Cardiol. 2000: 75 Suppl 1 S9-S15; discussion S17-9
• T cell homeostasis in patients with rheumatoid arthritis. Koetz K, Bryl E, Spickschen K, O'Fallon WM, Goronzy JJ, Weyand CM. Proc Natl Acad Sci U S A. 2000; 97 (16): 9203-8
• The role of T cells in rheumatoid arthritis. Weyand CM, Bryl E, Goronzy JJ. Arch Immunol Ther Exp (Warsz). 2000; 48 (5): 429-35
• Treatment of giant cell arteritis: interleukin-6 as a biologic marker of disease activity. Weyand CM, Fulbright JW, Hunder GG, Evans JM, Goronzy JJ. Arthritis Rheum. 2000; 43 (5): 1041-8
• [Clinical and genetic heterogeneity of rheumatoid arthritis]. Klimiuk PA, Weyand CM, Sierakowski S, Goronzy JJ. Postepy Hig Med Dosw. 2000; 54 (6): 845-53
• Aberrations in the primary T-cell receptor repertoire as a predisposition for synovial inflammation in rheumatoid arthritis. Yang H, Rittner H, Weyand CM, Goronzy JJ. J Investig Med. 1999; 47 (5): 236-45
• Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells. Kaiser M, Younge B, Björnsson J, Goronzy JJ, Weyand CM. Am J Pathol. 1999; 155 (3): 765-74
• HLA polymorphisms and T cells in rheumatoid arthritis. Weyand CM, Goronzy JJ. Int Rev Immunol. 1999; 18 (1-2): 37-59
• Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. Vallejo AN, Brandes JC, Weyand CM, Goronzy JJ. J Immunol. 1999; 162 (11): 6572-9
• Perturbation of the T-cell repertoire in patients with unstable angina. Liuzzo G, Kopecky SL, Frye RL, O'Fallon WM, Maseri A, Goronzy JJ, Weyand CM. Circulation. 1999; 100 (21): 2135-9
• T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease. Weyand CM, Goronzy JJ. Curr Opin Rheumatol. 1999; 11 (3): 210-7
• Tissue-destructive macrophages in giant cell arteritis. Rittner HL, Kaiser M, Brack A, Szweda LI, Goronzy JJ, Weyand CM. Circ Res. 1999; 84 (9): 1050-8