Stanford School of Medicine
Medicine

Department: Medicine

Division: Immunology & Rheumatology

  • Academic Appointments
    • Assistant Professor - Med Center Line, Medicine - Immunology & Rheumatology
    Clinical Focus
    • Immunology and Rheumatology
    • Rheumatology
    Research Interest

    Research interests include clinical epidemiology, translational studies, and clinical trials. Areas of interest include systemic lupus erythematosus, scleroderma, rheumatoid arthritis, connective tissue diseases, and relationships between autoimmune diseases and pregnancy.

  • Academic Appointments
    • Assistant Professor - Med Center Line, Medicine - Immunology & Rheumatology
    Clinical Focus
    • Immunology and Rheumatology
    • Rheumatology
    • Scleroderma, Systemic
  • Academic Appointments
    • Professor, Medicine - Immunology & Rheumatology
    • Member, Cancer Center
    Clinical Focus
    • Immunology
    • Immunology and Rheumatology
    Research Interest

    My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have idintified a gene (GRAIL) that seems to control T cell anergy and are defining the regulatory T cell core transcriptome. Additional studies are on the mechanism of effect of anti-CD3 antibodies in therapy of T1D.

  • Academic Appointments
    • Assistant Professor - Med Center Line, Dermatology
    • Assistant Professor - Med Center Line, Medicine - Immunology & Rheumatology
    • Member, Bio-X
    Clinical Focus
    • Dermatology
    • Autoimmune Diseases
    • Psoriasis
    Research Interest

    I am interested in all types of immune-mediated skin disease, with a focus on psoriasis and rheumatic skin disease. I co-direct a multi-disciplinary clinic dedicated to the care of patients with rheumatic skin diseases, such as lupus erythematosus, vasculitis, dermatyositis and scleroderma. I conduct multiple clinical trials and I participate in translational research with tissues obtained from a prospective cohort of patients with scleroderma, lupus, and dermatomyositis.

  • Academic Appointments
    • Emeritus (Active) Professor, Medicine - Immunology & Rheumatology
    • Emeritus Faculty, Acad Council, Medicine - Immunology & Rheumatology
    Clinical Focus
    • Immunology and Rheumatology
    • Rheumatology
    Research Interest

    National chronic disease data bank systems; clinical, epidemiology of arthritis; antecedents of human aging; assessment of, technology

  • Academic Appointments
    • Professor - Med Center Line, Medicine - Immunology & Rheumatology
    Clinical Focus
    • Rheumatology
    • Immunology/Rheumatology
    Research Interest

    Clinical trials and interventions in the rheumatic diseases including Rheumatoid Arthritis,Systemic Lupus Erythematosus, Systemic Sclerosis, Osteoarthritis.

  • Academic Appointments
    • Emeritus Faculty, Acad Council, Medicine - Immunology & Rheumatology
  • Academic Appointments
    • Emeritus (Active) Professor, Medicine - Immunology & Rheumatology
    Clinical Focus
    • Immunology
    • Immunology and Rheumatology
    • Internal Medicine
    Research Interest

    Organization of community health care programs; management of chronic disease; introduction and evaluation of patient education and self-care practices; evaluation of health care outcomes and health system performance.

  • Academic Appointments
    • Assistant Professor, Medicine - Immunology & Rheumatology
    Clinical Focus
    • Immunology and Rheumatology
    • Rheumatology
    • Gout
    Research Interest

    I am a clinical epidemiologist. My long-term goal is to develop ways and means of disease prevention in the context of rheumatic diseases. Currently, my core investigative areas are: 1) Cardiovascular impact of inflammatory arthritis 2) Healthcare utilization of populations 3) Methodological innovations for improvement of individual and population phenotyping and health outcome measurement 4)Health outcomes in extreme old age.

  • Academic Appointments
    • Professor - Med Center Line, Orthopaedic Surgery
    • Professor - Med Center Line (By courtesy), Medicine - Immunology & Rheumatology
    • Professor - Med Center Line (By courtesy), Surgery
    • Member, Bio-X
    Clinical Focus
    • Hand Surgery
    • Hand and Upper Extremity Surgery
    • Orthopaedic Surgery
    Research Interest

    Research Interests 1. Archiving, vitalizing, and innovating medical and surgical knowledge 2. Realizing surgical simulation 3. Studying the complexity of the human hand and upper limb: evolutionary history, comparative anatomy, and its role in cognition 4. Studying the various synthetic bone substitutes and factors as mechanical and biologic materials 5. Understanding the fracture of the distal radius, the most common fracture requiring treatment.

  • Academic Appointments
    • Emeritus (Active) Professor, Medicine - Immunology & Rheumatology
    • Emeritus Faculty, Acad Council, Medicine - Immunology & Rheumatology
    • Member, Cancer Center
    Research Interest

    Community based psycoeducational intervention studies of disease self management for people with chronic diseases. arthritis, lung diseases, heart disease AIDs, low back pain and diabetes. Programs and studies in Spanish and English. Interventions are in small groups, mailed or on the Internet.

  • Academic Appointments
    • Emeritus Faculty, Acad Council, Medicine - Immunology & Rheumatology
    • Member, Cancer Center
    Research Interest

    The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity. B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor. We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance. We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease.

  • Academic Appointments
    • Instructor, Medicine - Immunology & Rheumatology
    Research Interest

    Research: -- Graft-versus-Host Disease (GVHD) Protective Strategies -- Innate and Adaptive Regulatory T cells -- Immunoregulatory Networks after BMT -- Murine Modelling and Translation of Strategies for Transplant Tolerance Clinical: -- Non-myeloablative BMT strategies -- Pediatric Bone Marrow/Hematopoietic Stem Cell Transplantation -- International Development of Hematology/Oncology in India

  • Academic Appointments
    • Assistant Professor, Medicine - Immunology & Rheumatology
    • Member, Bio-X
    Clinical Focus
    • Immunology and Rheumatology
    • Rheumatology
    Research Interest

    Our lab studies the molecular mechanisms of and develops therapies to treat autoimmune and rheumatic diseases, with a focus on rheumatoid arthritis, multiple sclerosis, and osteoarthritis. The overriding objectives of our laboratory are: 1. To investigate the mechanisms underlying autoimmune diseases. 2. To develop diagnostics and therapeutics for autoimmune diseases. 3. To investigate the role of inflammation in osteoarthritis.

  • Academic Appointments
    • Instructor, Medicine - Immunology & Rheumatology
  • Academic Appointments
    • Professor, Medicine - Immunology & Rheumatology
    • Member, Cancer Center
    Clinical Focus
    • Immunology and Rheumatology
    • Rheumatology
    Research Interest

    Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation.

  • Academic Appointments
    • Associate Professor, Medicine - Immunology & Rheumatology
    • Member, Bio-X
    Clinical Focus
    • Immunology and Rheumatology
    • Rheumatology
    Research Interest

    The long-term research goal of Dr. Utz’s laboratory is (1) to develop a better understanding of the pathogenic mechanisms underlying systemic lupus erythematosus (SLE) and other autoimmune diseases by exploring signaling pathways that are activated during apoptosis; and (2) to better understand the complicated process of programmed cell death.

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