Ching-Pin Chang
Academic Appointments
- Associate Professor, Medicine - Cardiovascular Medicine
- Member, Bio-X
- Member, Child Health Research Institute
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 736-4108
Professional Overview
Honors and Awards
- Established Investigator Award, American Heart Association (2012-2016)
- New Faculty Award, California Institute of Regenerative Medicine (2008-2013)
- March of Dimes Research Program Award, March of Dimes Foundation (2007-2010)
- Medical Grant Award, Children's Heart Foundation (2007)
- Faculty Scholar Award, Donald E. and Delia B. Baxter Foundation (2006)
- National Scientist Development Award, American Heart Association (2005)
Professional Education
| Physician-Scientist Fellowship: | Howard Hughes Medical Institute, Cardiovascular Development (2004) |
| Cardiology Fellowship: | Stanford University Medical Center, Clinical Cardiology (2001) |
| Residency: | Massachusetts General Hospital, Harvard, Internal Medicine (1999) |
| Ph.D.: | Stanford University, Cancer Biology (1997) |
| M.D.: | National Taiwan University, Medicine |
Graduate & Fellowship Program Affiliations
Internet Links
Industry Relationships
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Scientific Focus
Current Research Interests
The ultimate goal of my laboratory is to define the molecular mechanisms underlying cardiovascular development and disease and translate the bench findings to clinical applications. One objective is to understand how the major types of cardiac cells (endocardial, myocardial, epicardial and neural crest cells) interact with each other to generate heart tissues. We are interested in chromatin regulation, transcriptional and signaling events that coordinate their interactions and assembly into heart tissues. We also study vascular regeneration and repair after injury with emphasis on vascular stem cell biology. The goal is to understand the developmental mechanisms that control tissue formation and repair in order to recapitulate the developmental processes for therapeutic or regenerative purposes. Another objective is to apply lessons learned from developmental studies to investigating the mechanisms underlying adult cardiovascular diseases. We are interested in determining the mechanistic links between cardiac development and adult cardiomyopathy. Furthermore, as part of the effort to understand tissue repair mechanisms following injury, we are investigating the biology of adult stem cells in various tissues that include hair follicles and blood vessels under different pathophysiological conditions. Our goal is to integrate developmental biology, adult pathophysiology, and regenerative medicine toward the understanding and treatment of human diseases.
Publications
- Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling. Cell. 2012; (5): 1083-96
- Epigenetics and cardiovascular development. Annu Rev Physiol. 2012: 41-68
- Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature. 2010; (7302): 62-7
- Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell. 2008; (2): 298-311
- NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006; (7093): 595-600
- A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 2004; (5): 649-63
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