Fredric Kraemer
Academic Appointments
- Professor, Medicine - Endocrinology, Gerontology, & Metabolism
- Member, Bio-X
Key Documents
Contact Information
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Clinical Offices
Endocrinology Clinic 300 Pasteur Dr A175 MC 5303 Stanford, CA 94305 Tel Work (650) 723-6961 Fax (650) 725-8418
- Academic Offices
Personal Information EmailAlternate Contact Tel Work 650-493-5000 x63184Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Endocrinology / Diabetes
- Lipid Metabolism Disorders
- Endocrinology and Metabolism
Administrative Appointments
- Associate Chief of Staff for Research and Development, VA Palo Alto Health Care System (2002 - 2007)
- Chief, Division of Endocrinology, Gerontology and Metabolism, Stanford University (2002 - present)
Honors and Awards
- Special Emphasis Research Career Award, NIH (1982-1987)
- Mellon Foundation Fellow, Stanford University (1983-1984)
- Hume Faculty Scholar, Stanford University (1984-1988)
- SmithKline Beecham Junior Faculty Award In Diabetes, SmithKline Beecham (1998)
- Stanford University Professorship in Endocrinology, Stanford University (2002)
Professional Education
| Fellowship: | Stanford University School of Medicine CA (1982) |
| Board Certification: | Endocrinology and Metabolism, American Board of Internal Medicine (1981) |
| Board Certification: | Internal Medicine, American Board of Internal Medicine (1977) |
| Internship: | Kings County Hospital NY (1977) |
| Medical Education: | New York University School of Medicine NY (1974) |
| BA: | Emory University, Chemistry (1970) |
Postdoctoral Advisees
Sumandeep Atwal, Jasdev Gondal, Zhigang Hu, Yihang Li, Cristina Panaroni, Hamid Saeed, Vikram Shende, Amar Singh, Madhurima Singh, XuDong Tang, Yi Shiuan Tzeng
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
Our research interests are in the general area of cellular lipid and lipoprotein metabolism. The work is aimed primarily at understanding the mechanisms regulating cholesterol and triglyceride accumulation in cells. We utilize a variety of techniques from cell biology, biochemistry, and molecular biology. Current research projects focus on the regulation of hormone sensitive lipase (HSL). HSL is an intracellular enzyme responsible for the cytosolic hydrolysis of intracellular triglyceride and cholesteryl esters. Thus, it has an important role in fat mobilization, but also in cholesterol metabolism. We are examining all aspects of the biology of HSL, including its mechanisms of action and its structure-function relationships in regard to adipose cell function and steroid hormone synthesis.
Publications
- Cholesterol ester droplets and steroidogenesis. Mol Cell Endocrinol. 2013; (1-2): 15-9
- Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress. J Lipid Res. 2013; (3): 734-43
- Hormone-sensitive lipase deficiency disturbs the fatty acid composition of mouse testis. Prostaglandins Leukot Essent Fatty Acids. 2013; (3): 227-33
- Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. J Biol Chem. 2013; (12): 8505-18
- Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013; (1): G72-86
- Regulation of Expression and Function of Scavenger Receptor Class B, Type I (SR-BI) by Na+/H+ Exchanger Regulatory Factors (NHERFs). J Biol Chem. 2013; (16): 11416-35
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