Paul Utz
Academic Appointments
- Professor, Medicine - Immunology & Rheumatology
- Member, Bio-X
Key Documents
Contact Information
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Clinical Offices
Immunology & Rheumatology Clinic 300 Pasteur Drive A175, MC 5303 Stanford, CA 94305 Tel Work (650) 723-6961 Fax (650) 725-8418
- Academic Offices
Personal Information EmailAlternate Contact Sharon Dickow Administrative Assistant Email Tel Work 723-7038Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Immunology and Rheumatology
- Rheumatology
Administrative Appointments
- Acting MSTP Associate Director, Medical Science Training Program, Stanford University School of Medicine (2009 - 2010)
- Member, Committee on Professionalism, Performance, and Promotion, Stanford University School of Medicine (2009 - present)
- Associate Director of Education, Stanford University, ITI Institute (2007 - present)
- Member, Cardiovascular Institute Steering Committee, Stanford University School of Medicine (2007 - 2010)
- Treasurer and Secretary, FOCIS, Federal of Clinical Immunology Societies (2007 - 2010)
- Board of Directors, Northern California Arthritis Foundation (2008 - 2009)
Honors and Awards
- Elected Member, American Society for Clinical Investigation (2007)
- Elected Member, The Kunkel Society (2006)
- Divisional Teaching Award, Stanford University (2002)
- Department of Medicine Teaching Award, Stanford University School of Medicine (2008)
- Baxter Fellowship, Donald and Delia Baxter (2000)
- Faculty Fellows Program, Stanford University School of Medicine (2009)
Professional Education
| Fellowship: | Brigham and Women's Hospital, Harvard Medical School, MA USA (1996) |
| Residency: | Brigham and Women's Hospital, Harvard Medical School, MA USA (1993) |
| Internship: | Brigham and Women's Hospital, Harvard Medical School, MA USA (1992) |
| Board Certification: | Rheumatology, American Board of Internal Medicine (1996) |
| Medical Education: | Stanford University School of Medicine CA (1991) |
| M.D.: | Stanford University, Medicine (1991) |
Graduate & Fellowship Program Affiliations
Community and International Work
- Stanford Institutes of Medicine Summer Research Program, SIMR (formerly CCIS), Stanford University
- Stanford EXPLORE, Stanford Univeristy
- CCIS Summer Student Intern Program, Stanford University
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
We are part of the Department of Medicine, Division of Immunology at Stanford University School of Medicine. Our lab is located in the brand new CCSR building, room 2215. We are interested in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), scleroderma, myositis, primary biliary chirosis (PBC), Sjogren's disease, insulin dependent diabetes (type I diabetes or IDDM), multiple sclerosis (MS) and mixed connective tissue disease (MCTD). The Utz lab is comprised of approximately 12 scientists, including Postdoctoral Fellows, Research Assistants, Undergraduate Students and Graduate Students. The focus of our research centers on serum autoantibodies produced in a variety of autoimmune diseases. In addition to trying to better understand the pathogenic mechanisms involved in autoimmunity, we are interested in developing bench-to-bedside technologies, including diagnostics and therapeutics, for human autoimmune diseases.
The four major goals of our studies are:
(1) To understand the mechanisms by which highly-conserved, diverse molecules and complexes such as histones and splicing particles are targeted by T and B lymphocytes and to determine how an immune response directed against ubiquitous antigens leads to organ-specific autoimmune disease.
(2) To use autoimmune sera as molecular probes to study basic cellular processes, particularly apoptosis signaling pathways, alternative RNA splicing, and endoplasmic reticulum protein transport.
(3) To invent and validate novel technologies for high-throughput, multiplex proteomics signaling molecules and studies. We are currently focusing on proteomics analysis of proteins secreted by immune cells, including cytokines and autoantibodies.
(4) To take advantage of the information provided by autoantibody profiling methods to develop antigen-specific tolerizing therapies for common autoimmune diseases. We collaborate closely with the Stanford laboratory of Dr. Larry Steinman, the principle discoverer of DNA tolerizing technology. Our long-term goal is to develop patient-specific, individualized therapeutics.
Publications
- Apoptosis and other immune biomarkers predict influenza vaccine responsiveness. Mol Syst Biol. 2013: 659
- Correction: Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Arthritis Res Ther. 2012; (4): 403
- Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. Clin Immunol. 2012; (2): 127-38
- New tools for classification and monitoring of autoimmune diseases. Nat Rev Rheumatol. 2012; (6): 317-28
- On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Nat Med. 2012; (9): 1434-40
- Therapeutic Toll-like receptor agonists directly influence mouse and human T cell lymphoma cell viability and cytokine secretion. Leuk Lymphoma. 2012; (1): 166-8
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