Maxence Nachury

Honors and Awards

• Fellowship Award in the Neurosciences, The Esther A. & Joseph Klingenstein Fund (2009-2012)
• Research Fellowship, Alfred P. Sloan Foundation (2009-2011)
• Basil O'Connor Award, March of Dimes (2009-2011)
• Scientist Development Award, American Heart Association (2009-2012)
• Career Development Award, AACR-Pancreatic Cancer Action Network (2009-2011)

Professional Education

Postdoctoral Advisees

Hua Jin , Susan White

Graduate & Fellowship Program Affiliations

• Molecular and Cellular Physiology

Web Site Links

• Nachury Lab

Research Interests

We study the primary cilium, a once-obscure cellular organelle recently "re-discovered" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.

Publications

• A BBSome subunit links ciliogenesis, microtubule stability, and acetylation. Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV. Dev Cell. 2008; 15 (6): 854-65
• A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK. Cell. 2007; 129 (6): 1201-13
• A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly Blower MD*, Nachury MV*, Heald R, Weis K. Cell. 2005; 121 (2): 223-234
• Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K. Cell. 2001; 104 (1): 95-106
• The BBSome. Jin H, Nachury MV. Curr Biol. 2009; 19 (12): R472-3