Miriam B. Goodman

Honors and Awards

• Klingenstein Fellow in Neuroscience, The Klingenstein Fund (2005-2008)
• McKnight Scholar Award, McKnight Endowment (2005-2008)
• Prize in Neurobiology, Eppendorf & Science (2004)
• Alfred P. Sloan Fellow, Alfred P. Sloan Foundation (2002-2004)
• Terman Fellow, Stanford University (2002-2005)

Professional Education

Postdoctoral Advisees

Amy Eastwood , Shana Geffeney , Dominique Glauser , Dong Wang

Graduate & Fellowship Program Affiliations

• Biophysics
• Molecular and Cellular Physiology
• Neurosciences

Web Site Links

• Goodman Lab Site

Current Research Interests

We study the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering (http://microsystems.stanford.edu) to develop and fabricate novel devices for the study of sensory transduction.

Publications

• Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans. Ramot D, MacInnis BL, Goodman MB. Nat Neurosci. 2008; 11 (8): 908-15
• Thermotaxis is a robust mechanism for thermoregulation in Caenorhabditis elegans nematodes. Ramot D, MacInnis BL, Lee HC, Goodman MB. J Neurosci. 2008; 28 (47): 12546-57
• Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons. Cueva JG, Mulholland A, Goodman MB. J Neurosci. 2007; 27 (51): 14089-98
• Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade. Brown AL, Fernandez-Illescas SM, Liao Z, Goodman MB. J Gen Physiol. 2007; 129 (2): 161-73
• Analysis of nematode mechanics by piezoresistive displacement clamp. Park SJ, Goodman MB, Pruitt BL. Proc Natl Acad Sci U S A. 2007; 104 (44): 17376-81