Yueh-hsiu Chien

Publications

• Cutting edge: Gammadelta intraepithelial lymphocytes of the small intestine are not biased toward thymic antigens. Jensen KD, Shin S, Chien YH. J Immunol. 2009; 182 (12): 7348-51
• Thymic maturation determines gammadelta T cell function, but not their antigen specificities. Jensen KD, Chien YH. Curr Opin Immunol. 2009; 21 (2): 140-5
• An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Adams EJ, Strop P, Shin S, Chien YH, Garcia KC. Nat Immunol. 2008; 9 (7): 777-84
• Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Jensen KD, Su X, Shin S, Li L, Youssef S, Yamasaki S, Steinman L, Saito T, Locksley RM, Davis MM, Baumgarth N, Chien YH. Immunity. 2008; 29 (1): 90-100
• Antigen recognition by gammadelta T cells. Chien YH, Konigshofer Y. Immunol Rev. 2007: 215 46-58
• Gammadelta T cells - innate immune lymphocytes? Konigshofer Y, Chien YH. Curr Opin Immunol. 2006; 18 (5): 527-33
• Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes. Chaparro RJ, Konigshofer Y, Beilhack GF, Shizuru JA, McDevitt HO, Chien YH. Proc Natl Acad Sci U S A. 2006; 103 (33): 12475-80
• Antigen recognition determinants of gammadelta T cell receptors. Shin S, El-Diwany R, Schaffert S, Adams EJ, Garcia KC, Pereira P, Chien YH. Science. 2005; 308 (5719): 252-5
• The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation. Gerke C, Falkow S, Chien YH. J Exp Med. 2005; 201 (3): 361-71
• Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Adams EJ, Chien YH, Garcia KC. Science. 2005; 308 (5719): 227-31
• Attributes of gammadelta intraepithelial lymphocytes as suggested by their transcriptional profile. Fahrer AM, Konigshofer Y, Kerr EM, Ghandour G, Mack DH, Davis MM, Chien YH. Proc Natl Acad Sci U S A. 2001; 98 (18): 10261-6
• A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule. Crowley MP, Fahrer AM, Baumgarth N, Hampl J, Gutgemann I, Teyton L, Chien Y. Science. 2000; 287 (5451): 314-6
• Antigen-recognition properties of murine gamma delta T cells. Chien YH, Hampl J. Springer Semin Immunopathol. 2000; 22 (3): 239-50
• Visualizing lymphocyte recognition. Wülfing C, Chien YH, Davis MM. Immunol Cell Biol. 1999; 77 (2): 186-7
• The specificity of a weak gamma delta TCR interaction can be modulated by the glycosylation of the ligand. Hampl J, Schild H, Litzenberger C, Baron M, Crowley MP, Chien YH. J Immunol. 1999; 163 (1): 288-94
• Suppression of T and B lymphocyte activation by a Yersinia pseudotuberculosis virulence factor, yopH. Yao T, Mecsas J, Healy JI, Falkow S, Chien Y. J Exp Med. 1999; 190 (9): 1343-50
• Visualizing T-cell recognition. Davis MM, Wülfing C, Krummel MF, Savage PA, Xu J, Sumen C, Dustin ML, Chien YH. Cold Spring Harb Symp Quant Biol. 1999: 64 243-51
• Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen. Gütgemann I, Fahrer AM, Altman JD, Davis MM, Chien YH. Immunity. 1998; 8 (6): 667-73
• Ligand recognition by alpha beta T cell receptors. Davis MM, Boniface JJ, Reich Z, Lyons D, Hampl J, Arden B, Chien Y. Annu Rev Immunol. 1998: 16 523-44
• Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development. Messika EJ, Lu PS, Sung YJ, Yao T, Chi JT, Chien YH, Davis MM. J Exp Med. 1998; 188 (3): 515-25
• A non classical MHC class I molecule, T 10, lacks peptide yet is thermally stable and immunological competent Y-h Chien, Crowley, M. P., Reich, Z., Mavaddat, N., Altman, J.,. J. Exp. Med.. 1997
• CD4 augments the response of a T cell to agonist but not to antagonist ligands. Hampl J, Chien YH, Davis MM. Immunity. 1997; 7 (3): 379-85
• T cell receptor biochemistry, repertoire selection and general features of TCR and Ig structure. Davis MM, Lyons DS, Altman JD, McHeyzer-Williams M, Hampl J, Boniface JJ, Chien Y. Ciba Found Symp. 1997: 204 94-100; discussion 100-4
• The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gammadelta T cell, G8. Crowley MP, Reich Z, Mavaddat N, Altman JD, Chien Y. J Exp Med. 1997; 185 (7): 1223-30
• A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Lyons DS, Lieberman SA, Hampl J, Boniface JJ, Chien Y, Berg LJ, Davis MM. Immunity. 1996; 5 (1): 53-61
• Early biochemical signals arise from low affinity TCR-ligand reactions at the cell-cell interface. Beeson C, Rabinowitz J, Tate K, Gütgemann I, Chien YH, Jones PP, Davis MM, McConnell HM. J Exp Med. 1996; 184 (2): 777-82
• Recognition by gamma/delta T cells. Chien YH, Jores R, Crowley MP. Annu Rev Immunol. 1996: 14 511-32
• Recognition by y* T cells Chien, Y-h.,, Jores, R., and Crowley, M.. Annu. Rev. Immunol.. 1996
• Gamma delta T cells. T cells with B-cell-like recognition properties. Chien YH, Jores R. Curr Biol. 1995; 5 (10): 1116-8
• T-cell receptor V-region usage and antigen specificity. The cytochrome c model system. Davis MM, McHeyzer-Williams M, Chien YH. Ann N Y Acad Sci. 1995: 756 1-11
• Issues concerning the nature of antigen recognition by alpha beta and gamma delta T-cell receptors. Davis MM, Chien Y. Immunol Today. 1995; 16 (7): 316-8
• CDR3 length in antigen-specific immune receptors. Rock EP, Sibbald PR, Davis MM, Chien YH. J Exp Med. 1994; 179 (1): 323-8
• The nature of MHC recognition by gd cells Chien Y-H., Schild H., Mavaddat N., Litzenberg C.L., Ehrich E.W., Davis M.M., Bluestone J., Matis L., Draper R.,. Cell. 1994
• The nature of major histocompatibility complex recognition by gamma delta T cells. Schild H, Mavaddat N, Litzenberger C, Ehrich EW, Davis MM, Bluestone JA, Matis L, Draper RK, Chien YH. Cell. 1994; 76 (1): 29-37
• How alpha beta T-cell receptors 'see' peptide/MHC complexes. Chien YH, Davis MM. Immunol Today. 1993; 14 (12): 597-602
• T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. Ehrich EW, Devaux B, Rock EP, Jorgensen JL, Davis MM, Chien YH. J Exp Med. 1993; 178 (2): 713-22
• Topology and affinity of T-cell receptor mediated recognition of peptide-MHC complexes. Davis MM, Chien Y. Curr Opin Immunol. 1993; 5 (1): 45-9
• Development of gamma delta T-cell subsets from fetal hematopoietic stem cells. Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL. Ann N Y Acad Sci. 1992: 651 21-32
• Expression of a fetal gamma delta T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion. Iwashima M, Green A, Bonyhadi M, Davis MM, Allison JP, Chien YH. Int Immunol. 1991; 3 (4): 385-93
• A gamma/delta cell receptor heterodimer induces the expression of CD4 and CD8 in thymocytes. Iwashima M, Davis MM, Chien YH. J Exp Med. 1991; 174 (1): 293-6
• A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien YH, Weissman IL. Cell. 1990; 62 (5): 863-74
• A possible basis for major histocompatibility complex-restricted T-cell recognition. Davis MM, Chien YH, Bjorkman PJ, Elliott JF, Iwashima M, Rock EP, Patten PA. Philos Trans R Soc Lond B Biol Sci. 1989; 323 (1217): 521-4
• Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region. Iwashima M, Green A, Davis MM, Chien YH. Proc Natl Acad Sci U S A. 1988; 85 (21): 8161-5
• The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes. Elliott JF, Rock EP, Patten PA, Davis MM, Chien YH. Nature. 1988; 331 (6157): 627-31
• T-cell receptor delta gene rearrangements in early thymocytes. Chien YH, Iwashima M, Wettstein DA, Kaplan KB, Elliott JF, Born W, Davis MM. Nature. 1987 Dec 24-31; 330 (6150): 722-7
• Identification and sequence of a fourth human T cell antigen receptor chain. Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A. Nature. 1987 Dec 10-16; 330 (6148): 569-72