Eugene Butcher

Publications

• DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC. Nat Immunol. 2007; 8 (3): 285-93
• Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC. Exp Hematol. 2006; 34 (8): 1106-14
• CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. Staton TL, Habtezion A, Winslow MM, Sato T, Love PE, Butcher EC. Nat Immunol. 2006; 7 (5): 482-8
• Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. Sato T, Thorlacius H, Johnston B, Staton TL, Xiang W, Littman DR, Butcher EC. J Immunol. 2005; 174 (1): 277-83
• Can cell systems biology rescue drug discovery? Butcher EC, Nat Rev Drug Discov. 2005; 4 (6): 461-7
• Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Debes GF, Arnold CN, Young AJ, Krautwald S, Lipp M, Hay JB, Butcher EC. Nat Immunol. 2005; 6 (9): 889-94
• Rules of chemokine receptor association with T cell polarization in vivo. Kim CH, Rott L, Kunkel EJ, Genovese MC, Andrew DP, Wu L, Butcher EC. J Clin Invest. 2001; 108 (9): 1331-9
• CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC. J Exp Med. 2001; 194 (10): 1541-7
• Separable effector T cell populations specialized for B cell help or tissue inflammation. Campbell DJ, Kim CH, Butcher EC. Nat Immunol. 2001; 2 (9): 876-81
• Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Beilhack A, Schulz S, Baker J, Beilhack GF, Nishimura R, Baker EM, Landan G, Herman EI, Butcher EC, Contag CH, Negrin RS. Blood. 2008; 111 (5): 2919-28
• Lymphocyte electrotaxis in vitro and in vivo. Lin F, Baldessari F, Gyenge CC, Sato T, Chambers RD, Santiago JG, Butcher EC. J Immunol. 2008; 181 (4): 2465-71
• Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Sigmundsdottir H, Butcher EC. Nat Immunol. 2008; 9 (9): 981-7
• Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC. J Exp Med. 2008; 205 (10): 2207-20
• CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC. Nat Immunol. 2008; 9 (11): 1253-60
• Modeling the role of homologous receptor desensitization in cell gradient sensing. Lin F, Butcher EC. J Immunol. 2008; 181 (12): 8335-43
• Selectin, platelet plays a critical role in granulocyte access to the pregnant mouse uterus under physiological and pathological conditions. Fernekorn U, Butcher EC, Behrends J, Karsten CM, Röbke A, Schulze TJ, Kirchner H, Kruse A. Biol Reprod. 2007; 76 (4): 645-53
• The germinal center response is impaired in the absence of T cell-expressed CXCR5. Arnold CN, Campbell DJ, Lipp M, Butcher EC. Eur J Immunol. 2007; 37 (1): 100-9
• RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells. Kalesnikoff J, Rios EJ, Chen CC, Nakae S, Zabel BA, Butcher EC, Tsai M, Tam SY, Galli SJ. Proc Natl Acad Sci U S A. 2006; 103 (8): 2659-64
• A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983. Gallatin WM, Weissman IL, Butcher EC. J Immunol. 2006; 177 (1): 5-9
• T cell chemotaxis in a simple microfluidic device. Lin F, Butcher EC. Lab Chip. 2006; 6 (11): 1462-9
• Chemoattractants, extracellular proteases, and the integrated host defense response. Zabel BA, Zuniga L, Ohyama T, Allen SJ, Cichy J, Handel TM, Butcher EC. Exp Hematol. 2006; 34 (8): 1021-32
• Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. Feng N, Jaimes MC, Lazarus NH, Monak D, Zhang C, Butcher EC, Greenberg HB. J Immunol. 2006; 176 (10): 5749-59
• Short-term homing assay reveals a critical role for lymphocyte function-associated antigen-1 in the hepatic recruitment of lymphocytes in graft-versus-host disease. Sato T, Habtezion A, Beilhack A, Schulz S, Butcher E, Thorlacius H. J Hepatol. 2006; 44 (6): 1132-40
• Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood. Zabel BA, Silverio AM, Butcher EC. J Immunol. 2005; 174 (1): 244-51
• Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982. Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL. J Immunol. 2005; 175 (3): 1363-72
• Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction. Nakamichi I, Habtezion A, Zhong B, Contag CH, Butcher EC, Omary MB. J Clin Invest. 2005; 115 (11): 3007-14
• Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling. Bernardini G, Kim JY, Gismondi A, Butcher EC, Santoni A. FASEB J. 2005; 19 (10): 1305-7
• Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment. Habtezion A, Toivola DM, Butcher EC, Omary MB. J Cell Sci. 2005; 118 (Pt 9): 1971-80
• Modified representational difference analysis: isolation of differentially expressed mRNAs from rare cell populations. O'Hara EF, Williams MB, Rott L, Abola P, Hansen N, Jones T, Gurjal MR, Federspiel N, Butcher EC. Anal Biochem. 2005; 336 (2): 221-30
• Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, Butcher EC. J Biol Chem. 2005; 280 (41): 34661-6
• Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Kunkel EJ, Plavec I, Nguyen D, Melrose J, Rosler ES, Kao LT, Wang Y, Hytopoulos E, Bishop AC, Bateman R, Shokat KM, Butcher EC, Berg EL. Assay Drug Dev Technol. 2004; 2 (4): 431-41
• Unique gene expression program of human germinal center T helper cells. Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Blood. 2004; 104 (7): 1952-60
• An integrative biology approach for analysis of drug action in models of human vascular inflammation. Kunkel EJ, Dea M, Ebens A, Hytopoulos E, Melrose J, Nguyen D, Ota KS, Plavec I, Wang Y, Watson SR, Butcher EC, Berg EL. FASEB J. 2004; 18 (11): 1279-81
• Method for analyzing signaling networks in complex cellular systems. Plavec I, Sirenko O, Privat S, Wang Y, Dajee M, Melrose J, Nakao B, Hytopoulos E, Berg EL, Butcher EC. Proc Natl Acad Sci U S A. 2004; 101 (5): 1223-8
• RhoA and zeta PKC control distinct modalities of LFA-1 activation by chemokines: critical role of LFA-1 affinity triggering in lymphocyte in vivo homing. Giagulli C, Scarpini E, Ottoboni L, Narumiya S, Butcher EC, Constantin G, Laudanna C. Immunity. 2004; 20 (1): 25-35
• Antigen-specific lymphocyte sequestration in lymphoid organs: lack of essential roles for alphaL and alpha4 integrin-dependent adhesion or Galphai protein-coupled receptor signaling. Arnold CN, Butcher EC, Campbell DJ. J Immunol. 2004; 173 (2): 866-73
• Murine CD8+ recent thymic emigrants are alphaE integrin-positive and CC chemokine ligand 25 responsive. Staton TL, Johnston B, Butcher EC, Campbell DJ. J Immunol. 2004; 172 (12): 7282-8
• Systems biology in drug discovery. Butcher EC, Berg EL, Kunkel EJ. Nat Biotechnol. 2004; 22 (10): 1253-9
• CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. Wilson E, Butcher EC. J Exp Med. 2004; 200 (6): 805-9
• Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Fernekorn U, Butcher EC, Behrends J, Hartz S, Kruse A. Eur J Immunol. 2004; 34 (12): 3423-33
• Maturation and trafficking markers on rotavirus-specific B cells during acute infection and convalescence in children. Jaimes MC, Rojas OL, Kunkel EJ, Lazarus NH, Soler D, Butcher EC, Bass D, Angel J, Franco MA, Greenberg HB. J Virol. 2004; 78 (20): 10967-76
• Targeting T cell responses by selective chemokine receptor expression. Campbell DJ, Debes GF, Johnston B, Wilson E, Butcher EC. Semin Immunol. 2003; 15 (5): 277-86
• Plasma-cell homing. Kunkel EJ, Butcher EC. Nat Rev Immunol. 2003; 3 (10): 822-9
• Chemokines in the systemic organization of immunity. Campbell DJ, Kim CH, Butcher EC. Immunol Rev. 2003: 195 58-71
• Differential chemokine responses and homing patterns of murine TCR alpha beta NKT cell subsets. Johnston B, Kim CH, Soler D, Emoto M, Butcher EC. J Immunol. 2003; 171 (6): 2960-9
• Rotavirus-specific B cells induced by recent infection in adults and children predominantly express the intestinal homing receptor alpha4beta7. Gonzalez AM, Jaimes MC, Cajiao I, Rojas OL, Cohen J, Pothier P, Kohli E, Butcher EC, Greenberg HB, Angel J, Franco MA. Virology. 2003; 305 (1): 93-105
• Motility analysis of pancreatic adenocarcinoma cells reveals a role for the atypical zeta isoform of protein kinase C in cancer cell movement. Laudanna C, Sorio C, Tecchio C, Butcher EC, Bonora A, Bassi C, Scarpa A. Lab Invest. 2003; 83 (8): 1155-63
• Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways. Xu B, Wagner N, Pham LN, Magno V, Shan Z, Butcher EC, Michie SA. J Exp Med. 2003; 197 (10): 1255-67
• CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Battistini L, Piccio L, Rossi B, Bach S, Galgani S, Gasperini C, Ottoboni L, Ciabini D, Caramia MD, Bernardi G, Laudanna C, Scarpini E, McEver RP, Butcher EC, Borsellino G, Constantin G. Blood. 2003; 101 (12): 4775-82
• Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Honjo M, Nakamura K, Yamashiro K, Kiryu J, Tanihara H, McEvoy LM, Honda Y, Butcher EC, Masaki T, Sawamura T. Proc Natl Acad Sci U S A. 2003; 100 (3): 1274-9
• Liver-infiltrating lymphocytes in end-stage hepatitis C virus: subsets, activation status, and chemokine receptor phenotypes. Boisvert J, Kunkel EJ, Campbell JJ, Keeffe EB, Butcher EC, Greenberg HB. J Hepatol. 2003; 38 (1): 67-75
• A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. Lazarus NH, Kunkel EJ, Johnston B, Wilson E, Youngman KR, Butcher EC. J Immunol. 2003; 170 (7): 3799-805
• CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. J Clin Invest. 2003; 111 (7): 1001-10
• Dendritic cells support sequential reprogramming of chemoattractant receptor profiles during naive to effector T cell differentiation. Kim CH, Nagata K, Butcher EC. J Immunol. 2003; 171 (1): 152-8
• Alterations in the expression of homing-associated molecules at the maternal/fetal interface during the course of pregnancy. Kruse A, Martens N, Fernekorn U, Hallmann R, Butcher EC. Biol Reprod. 2002; 66 (2): 333-45
• Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptors. Piccio L, Rossi B, Scarpini E, Laudanna C, Giagulli C, Issekutz AC, Vestweber D, Butcher EC, Constantin G. J Immunol. 2002; 168 (4): 1940-9
• Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice. Skovseth DK, Yamanaka T, Brandtzaeg P, Butcher EC, Haraldsen G. Am J Pathol. 2002; 160 (5): 1629-37
• Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression. Kim CH, Butcher EC, Johnston B. Trends Immunol. 2002; 23 (11): 516-9
• Homeostatic chemokines and the targeting of regional immunity. Kunkel E, Butcher E. Adv Exp Med Biol. 2002: 512 65-72
• Rapid acquisition of tissue-specific homing phenotypes by CD4(+) T cells activated in cutaneous or mucosal lymphoid tissues. Campbell DJ, Butcher EC. J Exp Med. 2002; 195 (1): 135-41
• Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Kunkel EJ, Boisvert J, Murphy K, Vierra MA, Genovese MC, Wardlaw AJ, Greenberg HB, Hodge MR, Wu L, Butcher EC, Campbell JJ. Am J Pathol. 2002; 160 (1): 347-55
• The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. Bowman EP, Kuklin NA, Youngman KR, Lazarus NH, Kunkel EJ, Pan J, Greenberg HB, Butcher EC. J Exp Med. 2002; 195 (2): 269-75
• Chemokines and the tissue-specific migration of lymphocytes. Kunkel EJ, Butcher EC. Immunity. 2002; 16 (1): 1-4
• Correlation of tissue distribution, developmental phenotype, and intestinal homing receptor expression of antigen-specific B cells during the murine anti-rotavirus immune response. Youngman KR, Franco MA, Kuklin NA, Rott LS, Butcher EC, Greenberg HB. J Immunol. 2002; 168 (5): 2173-81
• Chemokines in rapid leukocyte adhesion triggering and migration. Johnston B, Butcher EC. Semin Immunol. 2002; 14 (2): 83-92
• Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. Wright DE, Bowman EP, Wagers AJ, Butcher EC, Weissman IL. J Exp Med. 2002; 195 (9): 1145-54
• Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Kim CH, Johnston B, Butcher EC. Blood. 2002; 100 (1): 11-6
• Cytokine control of memory B cell homing machinery. Roy MP, Kim CH, Butcher EC. J Immunol. 2002; 169 (4): 1676-82
• Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers. Ku CC, Padilla JA, Grose C, Butcher EC, Arvin AM. J Virol. 2002; 76 (22): 11425-33
• Bovine gamma delta T cell subsets express distinct patterns of chemokine responsiveness and adhesion molecules: a mechanism for tissue-specific gamma delta T cell subset accumulation. Wilson E, Hedges JF, Butcher EC, Briskin M, Jutila MA. J Immunol. 2002; 169 (9): 4970-5
• Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine. Campbell DJ, Butcher EC. J Clin Invest. 2002; 110 (8): 1079-81
• Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. J Exp Med. 2001; 193 (12): 1373-81
• C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential. Andrew DP, Ruffing N, Kim CH, Miao W, Heath H, Li Y, Murphy K, Campbell JJ, Butcher EC, Wu L. J Immunol. 2001; 166 (1): 103-11
• Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. Kim CH, Kunkel EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, Butcher EC. J Clin Invest. 2001; 107 (5): 595-601
• CCR7 expression and memory T cell diversity in humans. Campbell JJ, Murphy KE, Kunkel EJ, Brightling CE, Soler D, Shen Z, Boisvert J, Greenberg HB, Vierra MA, Goodman SB, Genovese MC, Wardlaw AJ, Butcher EC, Wu L. J Immunol. 2001; 166 (2): 877-84
• Expression of chemokine receptors by lung T cells from normal and asthmatic subjects. Campbell JJ, Brightling CE, Symon FA, Qin S, Murphy KE, Hodge M, Andrew DP, Wu L, Butcher EC, Wardlaw AJ. J Immunol. 2001; 166 (4): 2842-8
• Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. Campbell JJ, Qin S, Unutmaz D, Soler D, Murphy KE, Hodge MR, Wu L, Butcher EC. J Immunol. 2001; 166 (11): 6477-82
• Nonpolarized memory T cells. Kim CH, Campbell DJ, Butcher EC. Trends Immunol. 2001; 22 (10): 527-30
• Immune cell trafficking in uterus and early life is dominated by the mucosal addressin MAdCAM-1 in humans. Salmi M, Alanen K, Grenman S, Briskin M, Butcher EC, Jalkanen S. Gastroenterology. 2001; 121 (4): 853-64
• Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Constantin G, Majeed M, Giagulli C, Piccio L, Kim JY, Butcher EC, Laudanna C. Immunity. 2000; 13 (6): 759-69
• Developmental switches in chemokine response profiles during B cell differentiation and maturation. Bowman EP, Campbell JJ, Soler D, Dong Z, Manlongat N, Picarella D, Hardy RR, Butcher EC. J Exp Med. 2000; 191 (8): 1303-18
• Expression of alpha4beta7 and E-selectin ligand by circulating memory B cells: implications for targeted trafficking to mucosal and systemic sites. Rott LS, Briskin MJ, Butcher EC. J Leukoc Biol. 2000; 68 (6): 807-14
• alpha(4)beta(7) independent pathway for CD8(+) T cell-mediated intestinal immunity to rotavirus. Kuklin NA, Rott L, Darling J, Campbell JJ, Franco M, Feng N, Müller W, Wagner N, Altman J, Butcher EC, Greenberg HB. J Clin Invest. 2000; 106 (12): 1541-52
• A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues. Pan J, Kunkel EJ, Gosslar U, Lazarus N, Langdon P, Broadwell K, Vierra MA, Genovese MC, Butcher EC, Soler D. J Immunol. 2000; 165 (6): 2943-9
• Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. Kunkel EJ, Campbell JJ, Haraldsen G, Pan J, Boisvert J, Roberts AI, Ebert EC, Vierra MA, Goodman SB, Genovese MC, Wardlaw AJ, Greenberg HB, Parker CM, Butcher EC, Andrew DP, Agace WW. J Exp Med. 2000; 192 (5): 761-8
• Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Campbell JJ, Butcher EC. Curr Opin Immunol. 2000; 12 (3): 336-41
• Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. Zabel BA, Agace WW, Campbell JJ, Heath HM, Parent D, Roberts AI, Ebert EC, Kassam N, Qin S, Zovko M, LaRosa GJ, Yang LL, Soler D, Butcher EC, Ponath PD, Parker CM, Andrew DP. J Exp Med. 1999; 190 (9): 1241-56
• L11, a unique anti-CD43 monoclonal antibody, inhibits the adoptive transfer of diabetes and pancreatic islet, salivary gland, and lacrimal gland inflammation in NOD/scid mice. Mikulowska A, Johnson GG, Berberian JM, Butcher EC, McEvoy LM, Michie SA. Cell Immunol. 1999; 194 (1): 112-7
• Inhibition of experimental autoimmune encephalomyelitis by a tyrosine kinase inhibitor. Constantin G, Laudanna C, Brocke S, Butcher EC. J Immunol. 1999; 162 (2): 1144-9
• Evidence of specialized leukocyte-vascular homing interactions at the maternal/fetal interface. Kruse A, Merchant MJ, Hallmann R, Butcher EC. Eur J Immunol. 1999; 29 (4): 1116-26
• Lymphocyte trafficking and regional immunity. Butcher EC, Williams M, Youngman K, Rott L, Briskin M. Adv Immunol. 1999: 72 209-53
• Cutting edge: developmental switches in chemokine responses during T cell maturation. Campbell JJ, Pan J, Butcher EC. J Immunol. 1999; 163 (5): 2353-7
• Anti-CD43 monoclonal antibody L11 blocks migration of T cells to inflamed pancreatic islets and prevents development of diabetes in nonobese diabetic mice. Johnson GG, Mikulowska A, Butcher EC, McEvoy LM, Michie SA. J Immunol. 1999; 163 (10): 5678-85
• Specialized patterns of vascular differentiation antigens in the pregnant mouse uterus and the placenta. Kruse A, Hallmann R, Butcher EC. Biol Reprod. 1999; 61 (6): 1393-401
• L-selectin-mediated leukocyte adhesion in vivo: microvillous distribution determines tethering efficiency, but not rolling velocity. Stein JV, Cheng G, Stockton BM, Fors BP, Butcher EC, von Andrian UH. J Exp Med. 1999; 189 (1): 37-50
• Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. Bowman EP, Campbell JJ, Druey KM, Scheschonka A, Kehrl JH, Butcher EC. J Biol Chem. 1998; 273 (43): 28040-8
• 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7. Campbell JJ, Bowman EP, Murphy K, Youngman KR, Siani MA, Thompson DA, Wu L, Zlotnik A, Butcher EC. J Cell Biol. 1998; 141 (4): 1053-9
• Molecular mechanisms of lymphocyte homing to peripheral lymph nodes. Warnock RA, Askari S, Butcher EC, von Andrian UH. J Exp Med. 1998; 187 (2): 205-16
• Chemokines and the arrest of lymphocytes rolling under flow conditions. Campbell JJ, Hedrick J, Zlotnik A, Siani MA, Thompson DA, Butcher EC. Science. 1998; 279 (5349): 381-4
• The memory B cell subset responsible for the secretory IgA response and protective humoral immunity to rotavirus expresses the intestinal homing receptor, alpha4beta7. Williams MB, Rosé JR, Rott LS, Franco MA, Greenberg HB, Butcher EC. J Immunol. 1998; 161 (8): 4227-35
• Expression of the mucosal homing receptor alpha4beta7 correlates with the ability of CD8+ memory T cells to clear rotavirus infection. Rosé JR, Williams MB, Rott LS, Butcher EC, Greenberg HB. J Virol. 1998; 72 (1): 726-30
• Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial venules. Berg EL, Mullowney AT, Andrew DP, Goldberg JE, Butcher EC. Am J Pathol. 1998; 152 (2): 469-77
• Asp-698 and Asp-811 of the integrin alpha4-subunit are critical for the formation of a functional heterodimer. Zeller Y, Lohr J, Sammar M, Butcher EC, Altevogt P. J Biol Chem. 1998; 273 (12): 6786-95
• Adhesion molecule phenotype of T lymphocytes in inflamed CNS. Engelhardt B, Martin-Simonet MT, Rott LS, Butcher EC, Michie SA. J Neuroimmunol. 1998; 84 (1): 92-104
• Human airway epithelial monolayers promote selective transmigration of memory T cells: a transepithelial model of lymphocyte migration into the airways. Miller LA, Butcher EC. Am J Respir Cell Mol Biol. 1998; 19 (6): 892-900
• Tyrphostin AG490, a tyrosine kinase inhibitor, blocks actively induced experimental autoimmune encephalomyelitis. Constantin G, Brocke S, Izikson A, Laudanna C, Butcher EC. Eur J Immunol. 1998; 28 (11): 3523-9
• Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC. J Biol Chem. 1998; 273 (46): 30306-15
• Multistep navigation and the combinatorial control of leukocyte chemotaxis. Foxman EF, Campbell JJ, Butcher EC. J Cell Biol. 1997; 139 (5): 1349-60
• Chemoattractant receptor cross talk as a regulatory mechanism in leukocyte adhesion and migration. Campbell JJ, Foxman EF, Butcher EC. Eur J Immunol. 1997; 27 (10): 2571-8
• Anti-CD43 inhibits monocyte-endothelial adhesion in inflammation and atherogenesis. McEvoy LM, Jutila MA, Tsao PS, Cooke JP, Butcher EC. Blood. 1997; 90 (9): 3587-94
• Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants. Laudanna C, Campbell JJ, Butcher EC. J Biol Chem. 1997; 272 (39): 24141-4
• Expression of mucosal homing receptor alpha4beta7 by circulating CD4+ cells with memory for intestinal rotavirus. Rott LS, Rosé JR, Bass D, Williams MB, Greenberg HB, Butcher EC. J Clin Invest. 1997; 100 (5): 1204-8
• Homing of naive and memory T lymphocyte subsets to Peyer's patches, lymph nodes, and spleen. Williams MB, Butcher EC. J Immunol. 1997; 159 (4): 1746-52
• Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis. McEvoy LM, Sun H, Tsao PS, Cooke JP, Berliner JA, Butcher EC. J Exp Med. 1997; 185 (12): 2069-77
• Specialization of mucosal follicular dendritic cells revealed by mucosal addressin-cell adhesion molecule-1 display. Szabo MC, Butcher EC, McEvoy LM. J Immunol. 1997; 158 (12): 5584-8
• RANTES stimulation of T lymphocyte adhesion and activation: role for LFA-1 and ICAM-3. Szabo MC, Butcher EC, McIntyre BW, Schall TJ, Bacon KB. Eur J Immunol. 1997; 27 (5): 1061-8
• Anti-CD43 inhibition of T cell homing. McEvoy LM, Sun H, Frelinger JG, Butcher EC. J Exp Med. 1997; 185 (8): 1493-8
• Novel method for following lymphocyte traffic in mice using [3H]glycerol labeling. Constantin G, Laudanna C, Butcher EC. J Immunol Methods. 1997; 203 (1): 35-44
• Vascular adhesion protein 1 (VAP-1) mediates lymphocyte subtype-specific, selectin-independent recognition of vascular endothelium in human lymph nodes. Salmi M, Tohka S, Berg EL, Butcher EC, Jalkanen S. J Exp Med. 1997; 186 (4): 589-600
• Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ. J Immunol. 1997; 159 (3): 1497-505
• Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Briskin M, Winsor-Hines D, Shyjan A, Cochran N, Bloom S, Wilson J, McEvoy LM, Butcher EC, Kassam N, Mackay CR, Newman W, Ringler DJ. Am J Pathol. 1997; 151 (1): 97-110
• Alpha 4 beta 7 integrin expression is associated with the leukemic evolution of human and murine T-cell lymphoblastic lymphomas. Dolcetti R, Giardini R, Doglioni C, Cariati R, Pomponi F, D'Orazi C, Rao S, Lazarovits AI, Butcher EC, Boiocchi M. Am J Pathol. 1997; 150 (5): 1595-605
• Differential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responses. Quiding-Järbrink M, Nordström I, Granström G, Kilander A, Jertborn M, Butcher EC, Lazarovits AI, Holmgren J, Czerkinsky C. J Clin Invest. 1997; 99 (6): 1281-6
• Function of lymphocyte homing-associated adhesion molecules on human natural killer and lymphokine-activated killer cells. Uksila J, Salmi M, Butcher EC, Tarkkanen J, Jalkanen S. J Immunol. 1997; 158 (4): 1610-7
• Homing potentials of circulating lymphocytes in humans depend on the site of activation: oral, but not parenteral, typhoid vaccination induces circulating antibody-secreting cells that all bear homing receptors directing them to the gut. Kantele A, Kantele JM, Savilahti E, Westerholm M, Arvilommi H, Lazarovits A, Butcher EC, Mäkelä PH. J Immunol. 1997; 158 (2): 574-9
• Genetic defect in T lymphocyte-specific homing into peripheral lymph nodes. Nakano H, Tamura T, Yoshimoto T, Yagita H, Miyasaka M, Butcher EC, Nariuchi H, Kakiuchi T, Matsuzawa A. Eur J Immunol. 1997; 27 (1): 215-21
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• CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein. Suzuki A, Andrew DP, Gonzalo JA, Fukumoto M, Spellberg J, Hashiyama M, Takimoto H, Gerwin N, Webb I, Molineux G, Amakawa R, Tada Y, Wakeham A, Brown J, McNiece I, Ley K, Butcher EC, Suda T, Gutierrez-Ramos JC, Mak TW. Blood. 1996; 87 (9): 3550-62
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• ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Steffen BJ, Breier G, Butcher EC, Schulz M, Engelhardt B. Am J Pathol. 1996; 148 (6): 1819-38
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• Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. Schlegel PG, Vaysburd M, Chen Y, Butcher EC, Chao NJ. J Immunol. 1995; 155 (8): 3856-65
• Soluble L-selectin (sCD62L) umbilical cord plasma levels increase with gestational age. Bührer C, Stibenz D, Graulich J, Gernhold U, Butcher EC, Dudenhausen JW, Obladen M. Pediatr Res. 1995; 38 (3): 336-41
• Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen. Kraal G, Schornagel K, Streeter PR, Holzmann B, Butcher EC. Am J Pathol. 1995; 147 (3): 763-71
• A central role for microvillous receptor presentation in leukocyte adhesion under flow. von Andrian UH, Hasslen SR, Nelson RD, Erlandsen SL, Butcher EC. Cell. 1995; 82 (6): 989-99
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• L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus. Michie SA, Streeter PR, Butcher EC, Rouse RV. Am J Pathol. 1995; 147 (2): 412-21
• L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. Sriramarao P, von Andrian UH, Butcher EC, Bourdon MA, Broide DH. J Immunol. 1994; 153 (9): 4238-46
• E-selectin mediates leukocyte rolling in interleukin-1-treated rabbit mesentery venules. Olofsson AM, Arfors KE, Ramezani L, Wolitzky BA, Butcher EC, von Andrian UH. Blood. 1994; 84 (8): 2749-58
• Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes. Erle DJ, Briskin MJ, Butcher EC, Garcia-Pardo A, Lazarovits AI, Tidswell M. J Immunol. 1994; 153 (2): 517-28
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• Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Steffen BJ, Butcher EC, Engelhardt B. Am J Pathol. 1994; 145 (1): 189-201
• Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Tsao PS, McEvoy LM, Drexler H, Butcher EC, Cooke JP. Circulation. 1994; 89 (5): 2176-82
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• Ligand-induced adhesion to activated endothelium and to vascular cell adhesion molecule-1 in lymphocytes transfected with the N-formyl peptide receptor. Honda S, Campbell JJ, Andrew DP, Engelhardt B, Butcher BA, Warnock RA, Ye RD, Butcher EC. J Immunol. 1994; 152 (8): 4026-35
• Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand. Ge AZ, Butcher EC. Gene. 1994; 138 (1-2): 201-6
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• Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells. Bargatze RF, Kurk S, Butcher EC, Jutila MA. J Exp Med. 1994; 180 (5): 1785-92
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• The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1. Sikorski EE, Hallmann R, Berg EL, Butcher EC. J Immunol. 1993; 151 (10): 5239-50
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• Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse. O'Neill JK, Butter C, Baker D, Gschmeissner SE, Kraal G, Butcher EC, Turk JL. Immunology. 1991; 72 (4): 520-5
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• A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. Berg EL, Robinson MK, Mansson O, Butcher EC, Magnani JL. J Biol Chem. 1991; 266 (23): 14869-72
• Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. Falanga PB, Butcher EC. Eur J Immunol. 1991; 21 (9): 2259-63
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• Dissection of murine lymphocyte-endothelial cell interaction mechanisms by SV-40-transformed mouse endothelial cell lines: novel mechanisms mediating basal binding, and alpha 4-integrin-dependent cytokine-induced adhesion. Harder R, Uhlig H, Kashan A, Schütt B, Duijvestijn A, Butcher EC, Thiele HG, Hamann A. Exp Cell Res. 1991; 197 (2): 259-67
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• Recombinant gamma interferon increases the binding of peripheral blood mononuclear leukocytes and a Leu-3+ T lymphocyte clone to cultured keratinocytes and to a malignant cutaneous squamous carcinoma cell line that is blocked by antibody against the LFA-1 molecule. Nickoloff BJ, Lewinsohn DM, Butcher EC, Krensky AM, Clayberger C. J Invest Dermatol. 1988; 90 (1): 17-22
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• Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic. Duijvestijn AM, Schreiber AB, Butcher EC. Proc Natl Acad Sci U S A. 1986; 83 (23): 9114-8
• Ontogeny of lymphocyte homing receptor expression in the mouse thymus. Reichert RA, Jerabek L, Gallatin WM, Butcher EC, Weissman IL. J Immunol. 1986; 136 (10): 3535-42
• Interactions between endothelial cells and leukocytes. Butcher EC, Lewinsohn D, Duijvestijn A, Bargatze R, Wu N, Jalkanen S. J Cell Biochem. 1986; 30 (2): 121-31
• The regulation of lymphocyte traffic. Butcher EC, Curr Top Microbiol Immunol. 1986: 128 85-122
• Lymphocyte homing receptors. Gallatin M, St John TP, Siegelman M, Reichert R, Butcher EC, Weissman IL. Cell. 1986; 44 (5): 673-80
• Phenotypic analysis of thymocytes that express homing receptors for peripheral lymph nodes. Reichert RA, Weissman IL, Butcher EC. J Immunol. 1986; 136 (10): 3521-8
• Dual immunofluorescence studies of cortisone-induced thymic involution: evidence for a major cortical component to cortisone-resistant thymocytes. Reichert RA, Weissman IL, Butcher EC. J Immunol. 1986; 136 (10): 3529-34
• Homing receptor-bearing thymocytes, an immunocompetent cortical subpopulation. Fink PJ, Gallatin WM, Reichert RA, Butcher EC, Weissman IL. Nature. 1985 Jan 17-23; 313 (5999): 233-5
• Prospects for understanding the role of lymphoid microenvironments in B cell differentiation in vivo. Butcher EC, Adv Exp Med Biol. 1985: 186 3-8
• Enrichment of murine and human Langerhans cells with solid phase immunoabsorption using pan-leukocyte monoclonal antibodies. Wood GS, Kosek J, Butcher EC, Morhenn VB. J Invest Dermatol. 1985; 84 (1): 37-40
• In vitro analysis of the homing properties of human lymphocytes: developmental regulation of functional receptors for high endothelial venules. Jalkanen ST, Butcher EC. Blood. 1985; 66 (3): 577-82
• Human T cell clones express functional homing receptors required for normal lymphocyte trafficking. Navarro RF, Jalkanen ST, Hsu M, Søenderstrup-Hansen G, Goronzy J, Weyand C, Fathman CG, Clayberger C, Krensky AM, Butcher EC. J Exp Med. 1985; 162 (3): 1075-80
• Human lymphocyte-high endothelial venule interaction: functional and molecular characterization. Jalkanen S, Bargatze R, Herron L, Butcher EC. Adv Exp Med Biol. 1985: 186 615-20
• Lymphocyte and lymphoma receptors utilized in differentiation, in homing, and in lymphomagenesis. Weissman IL, McGrath MS, Reichert RA, Gallatin WM, Ezine S, Fink P, Butcher EC, Marian J, O'Neill HC. Haematol Blood Transfus. 1985: 29 449-54
• Germinal center cells: antigen specificity, heavy chain class expression and evidence of memory. Kraal G, Weissman IL, Butcher EC. Adv Exp Med Biol. 1985: 186 145-51
• The role of carbohydrate in heterotypic cell-cell recognition: lymphocyte-high endothelial cell interaction as a model system. Butcher EC, Biol Cell. 1984; 51 (2): 248-50
• A homing receptor-bearing cortical thymocyte subset: implications for thymus cell migration and the nature of cortisone-resistant thymocytes. Reichert RA, Gallatin WM, Butcher EC, Weissman IL. Cell. 1984; 38 (1): 89-99
• Localization of lymphocyte subpopulations in peripheral lymphoid organs: directed lymphocyte migration and segregation into specific microenvironments. Rouse RV, Reichert RA, Gallatin WM, Weissman IL, Butcher EC. Am J Anat. 1984; 170 (3): 391-405
• Langerhans cells react with pan-leukocyte monoclonal antibody: ultrastructural documentation using a live cell suspension immunoperoxidase technique. Wood GS, Morhenn VB, Butcher EC, Kosek J. J Invest Dermatol. 1984; 82 (4): 322-5
• A cell-surface molecule involved in organ-specific homing of lymphocytes. Gallatin WM, Weissman IL, Butcher EC. Nature. 1983 Jul 7-13; 304 (5921): 30-4
• Germinal center B cells lack homing receptors necessary for normal lymphocyte recirculation. Reichert RA, Gallatin WM, Weissman IL, Butcher EC. J Exp Med. 1983; 157 (3): 813-27
• Differences in in vivo distribution and homing of T cell subsets to mucosal vs nonmucosal lymphoid organs. Kraal G, Weissman IL, Butcher EC. J Immunol. 1983; 130 (3): 1097-102
• Genetic control of T-cell subset representation in inbred mice. Kraal G, Weissman IL, Butcher EC. Immunogenetics. 1983; 18 (6): 585-92
• Abnormal migration of T lymphocyte clones. Dailey MO, Fathman CG, Butcher EC, Pillemer E, Weissman I. J Immunol. 1982; 128 (5): 2134-6
• Germinal centre B cells: antigen specificity and changes in heavy chain class expression. Kraal G, Weissman IL, Butcher EC. Nature. 1982; 298 (5872): 377-9
• Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL. J Immunol. 1982; 129 (6): 2698-707
• Differences in the migration of B and T lymphocytes: organ-selective localization in vivo and the role of lymphocyte-endothelial cell recognition. Stevens SK, Weissman IL, Butcher EC. J Immunol. 1982; 128 (2): 844-51
• Selective migration of murine lymphocytes and lymphoblast populations and the role of endothelial cell recognition. Butcher EC, Kraal G, Stevens SK, Weissman IL. Adv Exp Med Biol. 1982: 149 199-206
• Surface phenotype and migratory capability of Peyer's patch germinal center cells. Butcher EC, Reichert RA, Coffman RL, Nottenburg C, Weissman IL. Adv Exp Med Biol. 1982: 149 765-72
• Normal and neoplastic lymphocyte maturation. Weissman IL, McGrath MS, Pillemer E, Hollander N, Rouse RV, Jerabek L, Stevens SK, Scollay RG, Butcher EC. J Supramol Struct Cell Biochem. 1981; 15 (3): 303-14
• Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules. Butcher EC, Scollay RG, Weissman IL. Eur J Immunol. 1980; 10 (7): 556-61
• Thymus cell migration. Quantitative aspects of cellular traffic from the thymus to the periphery in mice. Scollay RG, Butcher EC, Weissman IL. Eur J Immunol. 1980; 10 (3): 210-8
• Cellular, genetic, and evolutionary aspects of lymphocyte interactions with high-endothelia venules. Butcher EC, Weissman IL. Ciba Found Symp. 1980: 71 265-86
• Direct fluorescent labeling of cells with fluorescein or rhodamine isothiocyanate. I. Technical aspects. Butcher EC, Weissman IL. J Immunol Methods. 1980; 37 (2): 97-108
• Direct fluorescent labeling of cells with fluorescein or rhodamine isothiocyanate. II. Potential application to studies of lymphocyte migration and maturation. Butcher EC, Scollay RG, Weissman IL. J Immunol Methods. 1980; 37 (2): 109-21
• Lymphocyte adherence to high endothelial venules: characterization of a modified in vitro assay, and examination of the binding of syngeneic and allogeneic lymphocyte populations. Butcher EC, Scollay RG, Weissman IL. J Immunol. 1979; 123 (5): 1996-2003
• The pathology and homing of a transplantable murine B cell leukemia (BCL1). Warnke RA, Slavin S, Coffman RL, Butcher EC, Knapp MR, Strober S, Weissman IL. J Immunol. 1979; 123 (3): 1181-8
• The lymphoid system. Its normal architecture and the potential for understanding the system through the study of lymphoproliferative diseases. Weissman IL, Warnke R, Butcher EC, Rouse R, Levy R. Hum Pathol. 1978; 9 (1): 25-45
• Measurement of nanogram quantities of protein by hydrolysis followed by reaction with orthophthalaldehyde or determination of glutamate. Butcher EC, Lowry OH. Anal Biochem. 1976; 76 (2): 502-23