Stephen Galli

Clinical Focus

• Pathology
• Pathology and Laboratory Medicine

Administrative Appointments

• Chair, Stanford University School of Medicine - Pathology (1999 - present)

Professional Education

Postdoctoral Advisees

Jennifer Lilla, Kaori Mukai, Laurent Reber

Web Site Links

• Galli Lab

Research Interests

Mast cells, which normally reside in the tissues, and basophils, which circulate in the blood, are major effector cells of asthma and other IgE-associated allergic disorders and immune responses to parasites. However, mast cells also have been implicated (as effector and/or immunoregulatory cells) in many other settings, including certain autoimmune or inflammatory disorders, innate immune responses to pathogens and resistance to exogenous and exogenous agents which can express significant toxicity; mast cells also may contribute importantly, in certain settings, to angiogenesis, the regulation of epithelial development and function and fibrosis and other examples of tissue remodeling.

The goals of Dr. Galli’s laboratory are to develop and employ genetic approaches in mice to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to elucidate the roles of these cells in health and disease. In parallel with these mouse studies, we investigate the roles of mast cells in human health and disease by conducting studies of human mast cells, or by analyzing specimens derived from patients with asthma or other disorders in which mast cell have been implicated.

Publications

• Pillars Article: Fate of Bone Marrow-Derived Cultured Mast Cells After Intracutaneous, Intraperitoneal, And Intravenous Transfer Into Genetically Mast Cell-Deficient W/Wv Mice. Evidence That Cultured Mast Cells Can Give Rise To Both Connective Tissue Type And Mucosal Mast Cells. The Journal of Experimental Medicine. 1985. 162: 1025-1043. Nakano T, Sonoda T, Hayashi C, Yamatodani A, Kanayama Y, Yamamura TI, Asai H, Yonezawa T, Kitamura Y, Galli SJ. J Immunol. 2009; 183 (11): 6863-6881
• The Role of Recipient Mast Cells in Acute and Chronic Cardiac Allograft Rejection in C57BL/6-Kit(W-sh/W-sh) Mice. Itoh S, Nakae S, Velotta JB, Kosuge H, Connolly A, Tsai M, Adachi H, Galli SJ, Robbins RC, Fischbein MP. J Heart Lung Transplant. 2009
• Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC. J Exp Med. 2008; 205 (10): 2207-20
• Rabaptin-5 regulates receptor expression and functional activation in mast cells. Rios EJ, Piliponsky AM, Ra C, Kalesnikoff J, Galli SJ. Blood. 2008; 112 (10): 4148-57
• Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Galli SJ, Grimbaldeston M, Tsai M. Nat Rev Immunol. 2008; 8 (6): 478-86