Stephen Galli
Academic Appointments
- Professor, Pathology
- Professor, Microbiology & Immunology
- Member, Bio-X
- Member, Cancer Center
Contact Information
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Clinical Offices
Department of Pathology 300 Pasteur Dr L235 MC 5324 Stanford, CA 94305 Tel Work (650) 723-7975 Fax (650) 725-6902Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
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Academic Offices
Personal Information Email Tel (650) 723-7975Administrative Contact Rochelle Roberts Administrative Assistant Email Tel Work 650-723-7975Not for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Pathology
- Pathology and Laboratory Medicine
Administrative Appointments
- Chair, Stanford University School of Medicine - Pathology (1999 - present)
Professional Education
| Fellowship: | Massachusetts General Hospital, MA (1979) |
| Residency: | Massachusetts General Hospital, MA (1977) |
| Medical Education: | Harvard Medical School, MA (1973) |
Postdoctoral Advisees
Web Site Links
Scientific Focus
Research Interests
Mast cells, which normally reside in the tissues, and basophils, which circulate in the blood, are major effector cells of asthma and other IgE-associated allergic disorders and immune responses to parasites. However, mast cells also have been implicated (as effector and/or immunoregulatory cells) in many other settings, including certain autoimmune or inflammatory disorders, innate immune responses to pathogens and resistance to exogenous and exogenous agents which can express significant toxicity; mast cells also may contribute importantly, in certain settings, to angiogenesis, the regulation of epithelial development and function and fibrosis and other examples of tissue remodeling.
The goals of Dr. Galli’s laboratory are to develop and employ genetic approaches in mice to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to elucidate the roles of these cells in health and disease. In parallel with these mouse studies, we investigate the roles of mast cells in human health and disease by conducting studies of human mast cells, or by analyzing specimens derived from patients with asthma or other disorders in which mast cell have been implicated.
Publications
- Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med. 2008; (4): 392-8
- IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro. Lab Invest. 2008; (11): 1134-42
- Rabaptin-5 regulates receptor expression and functional activation in mast cells. Blood. 2008; (10): 4148-57
- New developments in mast cell biology. Nat Immunol. 2008; (11): 1215-23
- Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis. J Dermatol Sci. 2008; (1): 7-19
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