Leonard Herzenberg

Administrative Appointments

• Professor, Genetics (1959 - present)

Honors and Awards

• Kyoto Prize in Advance Technology, Inamori Foundation (2006)
• Prize in Immunology, Novartis Award (2004)
• Edwin D. Ullman Award, American Association of Clinical Chemistry (2002)
• Lifetime Servicce Award, AAI (1998)
• Member, National Academy of Scientists (1982)

Professional Education

Graduate & Fellowship Program Affiliations

• Genetics
• Immunology

Web Site Links

• Herzenberg Laboratory Home Page

Research Interests

Dr. Leonore Herzenberg and I maintain jointly functioning laboratory groups. Our focus is on gene regulation in the immune system, development and function of B cell subpopulations, and applications of Fluorescence-Activated Cell Sorting (FACS).

We have been interested for many years in the genetics and development of the immune system in mice. A major tool we have developed to aid us in this work is the Fluorescence-Activated Cell Sorter(FACS), which permits rapid analysis and sorting of millions of viable cells based on fluorescence marking. Recently we have studied gene regulation at the individual cell level using the FACS and either fluorogenic substrates for lac Z (ß-galactosidase) or Green Fluorescent Protein(GFP).

Current Studies include:

1) Redox regulation of gene expression and diseases, such as AIDS, sepsis, and inflammation.

2) Regulation of lymphocyte development, especially B and T cells.

3) Apoptosis in the immune system and in disease processes, such as cancer and infection.

4) Development of multi-parameter FACS (Flow Cytometry) and Scanning Cytometry.

5) The cell biology of AIDS in model systems and patients.

In addition to improving FACS operations with a dedicated group of engineers, computer scientists, programmers, and a physicist, opportunities always exist for technologically oriented students interested in molecular biology and immunology.

Publications

• N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency. Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA. Curr Opin Pharmacol. 2007; 7 (4): 355-9
• Importance of culturing primary lymphocytes at physiological oxygen levels. Atkuri KR, Herzenberg LA, Niemi AK, Cowan T, Herzenberg LA. Proc Natl Acad Sci U S A. 2007; 104 (11): 4547-52
• Interpreting flow cytometry data: a guide for the perplexed. Herzenberg LA, Tung J, Moore WA, Herzenberg LA, Parks DR. Nat Immunol. 2006; 7 (7): 681-5
• High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Tirouvanziam R, Conrad CK, Bottiglieri T, Herzenberg LA, Moss RB, Herzenberg LA. Proc Natl Acad Sci U S A. 2006; 103 (12): 4628-33
• FACS innovation: a view from Stanford. Herzenberg LA, Clin Invest Med. 2004; 27 (5): 240-52