Lawrence Steinman

Clinical Focus

• Neurology
• Neurology, Pediatric
• Multiple Sclerosis, Myasthenia Gravis, Immune Disorders

Administrative Appointments

• Chairman, Interdepartmental Program in Immunology, Interdepartmental Program in Immunology, Stanford University (2002 - 2009)

Honors and Awards

• Friedrich Sasse Prize, Free Univ.of Berlin (1994)
• Sen. Jacob Javits Award, US Congress (1988-2002)
• John M. Dystel Prize, American Academy of Neurology and National MS Society (2004)

Professional Education

Postdoctoral Advisees

Robert Axtell, Katja Herges, Hedwich Kuipers, Michael Kurnellas, Brigit de Jong

Graduate & Fellowship Program Affiliations

• Immunology
• Neurosciences

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. View Full Information

Research Interests

Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

Publications

• PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Mukundan L, Odegaard JI, Morel CR, Heredia JE, Mwangi JW, Ricardo-Gonzalez RR, Goh YP, Eagle AR, Dunn SE, Awakuni JU, Nguyen KD, Steinman L, Michie SA, Chawla A. Nat Med. 2009
• Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Platten M, Youssef S, Hur EM, Ho PP, Han MH, Lanz TV, Phillips LK, Goldstein MJ, Bhat R, Raine CS, Sobel RA, Steinman L. Proc Natl Acad Sci U S A. 2009; 106 (35): 14948-53
• A molecular trio in relapse and remission in multiple sclerosis. Steinman L, Nat Rev Immunol. 2009; 9 (6): 440-7
• Innate and adaptive autoimmunity directed to the central nervous system. Bhat R, Steinman L. Neuron. 2009; 64 (1): 123-32
• A rush to judgment on Th17. Steinman L, J Exp Med. 2008; 205 (7): 1517-22