The goal of this laboratory is to better understand dendritic cell biology with the objective of using this information to discover and develop more effective immunotherapeutic approaches to disease. We pursue this goal by performing experiments in both mice and humans. In our initial clinical studies antigen pulsed dendritic cells were administered to patients with cancer or life-threatening viral infections in order to induce specific immunity. The results of these trials have been extremely encouraging. More recently we have focused our studies on the development and life cycle of dendritic cells, including Langerhans cells, and the results have not only shed new light on dendritic cell biology but also have led to our ability to target dendritic cells in vivo without having to manipulate these cells in vitro. We believe that this new approach will eventually make it possible to downregulate as well as upregulate the immune system in an antigen specific manner.
Publications
Standley SM,
Mende I, Goh SL, Kwon YJ, Beaudette TT, Engleman EG, Fréchet JM
"Incorporation of CpG oligonucleotide ligand into protein-loaded particle vaccines promotes antigen-specific CD8 T-cell immunity."
Bioconjug Chem
2007 Jan-Feb;
18:
1:
77-83
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Zhang AL,
Colmenero P, Purath U, Teixeira de Matos C, Hueber W, Klareskog L, Tarner IH, Engleman EG, Soderstrom K
"Natural killer cells trigger differentiation of monocytes into dendritic cells."
Blood
2007;
More »
Saji H,
Song W, Furumoto K, Kato H, Engleman EG
"Systemic antitumor effect of intratumoral injection of dendritic cells in combination with local photodynamic therapy."
Clin Cancer Res
2006;
12:
8:
2568-74
More »
Okano F,
Merad M, Furumoto K, Engleman EG
"In vivo manipulation of dendritic cells overcomes tolerance to unmodified tumor-associated self antigens and induces potent antitumor immunity."
J Immunol
2005;
174:
5:
2645-52
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Karsunky H,
Merad M, Mende I, Manz MG, Engleman EG, Weissman IL
"Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors."
Exp Hematol
2005;
33:
2:
173-81
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