Department: Genetics

• Faculty (38)
• Postdocs (47)
• All

A

• 
  Altman, Russ 
  Academic Appointments

  • Professor, Bioengineering
  • Professor, Medicine - Stanford Medical Informatics
  • Professor (By courtesy), Computer Science
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  I refer you to my web page for detailed list of interests, projects and publications. In addition to pressing the link here, you can search "Russ Altman" on http://www.google.com/

• 
  Attardi, Laura 
  Academic Appointments

  • Associate Professor, Radiation Oncology - Radiation Biology
  • Associate Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.

B

• 
  Baker, Julie 
  Academic Appointments

  • Associate Professor, Genetics
  • Associate Professor (By courtesy), Obstetrics & Gynecology
  • Member, Bio-X
  Research Interest

  Our laboratory is focused on identifying proteins based upon their ability to alter a variety of cell fate decisions - including mesodermal, endodermal, neural, endothelial, and somitic - within the vertebrate embryo.

• 
  Barsh, Gregory 
  Academic Appointments

  • Professor, Genetics
  • Professor, Pediatrics - Genetics
  Research Interest

  Genetics of color variation

• 
  Brunet, Anne 
  Academic Appointments

  • Assistant Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.

C

• 
  Calos, Michele 
  Academic Appointments

  • Professor, Genetics
  Research Interest

  My lab is developing novel vectors and strategies for gene therapy. We are focused on creating and using plasmid DNA vectors that integrate into the genome in a site-specific manner. We are developing innovative gene therapies for a variety of tissues and diseases, including approaches involving stem cells.

• 
  Cavalli-Sforza, Luigi 
  Academic Appointments

  • Emeritus Faculty, Acad Council, Genetics
  Research Interest

  My research is dedicated to the study of the origin of modern humans and their evolutionary history by using genetic markers. Presently, the laboratory is concentrating on the study of Y chromosomes. My personal interest has also been dedicated for a long time to a multidisciplinary approach to human evolution, including demography, archeology, linguistics, anthropology, surnames, and to the interactions of genetic and cultural evolution.

• 
  Cherry, JMichael 
  Academic Appointments

  • Associate Professor (Research), Genetics
  • Member, Bio-X
  Research Interest

  The focus of my group is the application of bioinformatics to the collection and dissemination genetic, genomic and cellular information. We abstracts the published results into our database, SGD. We explore the volumes of information that have been elucidated for the budding yeast S. cerevisiae. My research is the applied use computers and databases: designing a resource to effectively provide biological information to the research community, and the development of the Gene Ontology.

• 
  Cohen, Stanley 
  Academic Appointments

  • Professor, Genetics
  • Professor, Medicine
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  We study the functional and structural signals that govern mRNA decay and gene expression in bacteria, as well as mechanisms affecting aging and the ability of mammalian cells to support the propagation of viruses. A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.

D

• 
  Davis, Ronald 
  Academic Appointments

  • Professor, Biochemistry
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  We are using Saccharomyces cerevisiae and Human to conduct whole genome analysis projects. The yeast genome sequence has approximately 6,000 genes. We have made a set of haploid and diploid strains (21,000) containing a complete deletion of each gene. In order to facilitate whole genome analysis each deletion is molecularly tagged with a unique 20-mer DNA sequence. This sequence acts as a molecular bar code and makes it easy to identify the presence of each deletion.

F

• 
  Fire, Andrew 
  Academic Appointments

  • Professor, Pathology
  • Professor, Genetics
  Research Interest

  We study natural cellular mechanisms for adapting to genetic change. These include systems activated during normal development and those for detecting and responding to foreign or unwanted genetic activity. Underlying these studies are questions of how a cells can distinguish information as "self" versus "nonself" or "wanted" versus "unwanted".

• 
  Ford, James 
  Academic Appointments

  • Associate Professor, Medicine - Oncology
  • Associate Professor, Genetics
  • Associate Professor (By courtesy), Pediatrics
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Cancer Genetics
  • Gastrointestinal Cancers - Genetics
  • Gastrointestinal Cancers - Medical Oncology
  Research Interest

  Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNAdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Francke, Uta 
  Academic Appointments

  • Professor, Genetics
  • Professor, Pediatrics
  Clinical Focus

  • Clinical Genetics
  • Neurogenetics
  Research Interest

  Functional consequences and pathogenetic mechanisms of mutations and microdeletions in human neurogenetic syndromes and mouse models: Williams-Beuren syndrome, a heterozygous 1.6 megabase deletion; Rett syndrome, caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Mechanisms of genomic imprinting: Prader Willi syndrome

  Practices at Lucile Packard Children's Hospital
• 
  Fuller, Margaret 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.

G

• 
  Greely, Henry T
  Academic Appointments

  • Professor, Law School - Law Faculty Matters
  • Professor (By courtesy), Genetics
  • Member, Bio-X

H

• 
  Herzenberg, Leonore A
  Academic Appointments

  • Professor (Research), Genetics
  • Member, Cancer Center
  Research Interest

  B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibodyresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays.

• 
  Herzenberg, Leonard 
  Academic Appointments

  • Emeritus (Active) Professor, Genetics
  • Member, Bio-X
  Research Interest

  Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated CellSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC).

K

• 
  Kay, Mark 
  Academic Appointments

  • Professor, Pediatrics - Human Gene Therapy
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Mark A. Kay, M.D., Ph.D. Director of the Program in Human Gene Therapy and Professor in the Departments of Pediatrics and Genetics. Respected worldwide for his work in gene therapy for hemophilia, Dr. Kay and his laboratory focus on establishing the scientific principles and developing the technologies needed for achieving persistent and therapeutic levels of gene expression in vivo. The major disease models are hemophilia, hepatitis C, and hepatitis B viral infections.

• 
  Kim, Stuart 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor (By courtesy), Chemical and Systems Biology
  • Professor, Genetics
  Research Interest

  1. Functional genomic approaches to study complex biological networks 2. Mechanisms of aging in worms and in humans.

• 
  Klein, Teri 
  Academic Appointments

  • Sr Research Engineer (PI Waiver), Genetics
  Research Interest

  Co-founder, Pacific Symposium on Biocomputing NIEHS, Site Visit Reviewer NIH, Study Section Reviewer

• 
  Kwan, Andrea 
  Academic Appointments

  • Lecturer, Genetics
• 
  Kwan, Andrew S
  Academic Appointments

  • Lecturer, Genetics

L

• 
  Lipsick, Joseph 
  Academic Appointments

  • Professor, Pathology
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Function and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.

M

• 
  Myers, Richard 
  Academic Appointments

  • Professor, Genetics
  • Member, Bio-X
  Research Interest

  Molecular basis of human inherited diseases and traits, including Huntington disease, Parkinson disease, bipolar disease, cancer, insulin resistance and atherosclerosis; genome-wide analysis of transcriptional regulation in humans, including global characterization of cis- and trans-acting components; genetic and evolutionary analysis of human populations; genomic analysis of vertebrate evolution; genome analysis, including large-scale DNA sequencing.

O

• 
  Ormond, Kelly E
  Academic Appointments

  • Associate Professor (Teaching), Genetics
  Research Interest

  While my primary role is to direct the MS in Human Genetics and Genetic Counseling program, my research focuses on the intersection between genetics and ethics, particularly around informed consent and patient decision making. I am also very interested in how genetic counseling and disability interface.

P

• 
  Pringle, John R
  Academic Appointments

  • Professor, Genetics
  Research Interest

  Much of our research exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis. In another project, we are developing the small sea anemone Aiptasia as a model system for study of the molecular and cellular biology of dinoflagellate-cnidarian symbiosis, which is critical for the survival of most corals but still very poorly understood.

S

• 
  Sage, Julien 
  Academic Appointments

  • Assistant Professor, Pediatrics - Cancer Biology
  • Assistant Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our goal is to define the molecular basis of cancer initiation and progression, focusing on the RB (retinoblastoma) tumor suppressor gene family. In particular, we investigate how RB and its family members p107 and p130 control embryonic and adult stem cells to ensure normal development and prevent cancer.

• 
  Scott, Matthew 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.

• 
  Sherlock, Gavin J
  Academic Appointments

  • Assistant Professor (Research), Genetics
  • Member, Cancer Center
  Research Interest

  Defining the transcriptome of S. cerevisiae; chromosomal evolution in hybrid yeast species; genome database for Candida albicans; the Stanford Microarray Database; bioinformatics tools for analysing expression data.

• 
  Sidow, Arend 
  Academic Appointments

  • Associate Professor, Pathology
  • Associate Professor, Genetics
  • Member, Bio-X
  Research Interest

  We study the function and molecular evolution of proteins and noncoding functional elements in the genome. Please refer to our web site for more information: http://mendel.stanford.edu/SidowLab/index.html

• 
  Snyder, Michael 
  Academic Appointments

  • Professor, Genetics
  • Member, Cancer Center
• 
  Stearns, Tim 
  Academic Appointments

  • Professor, Biology (School of Humanities and Sciences)
  • Professor, Genetics
  • Member, Bio-X
  Research Interest

  We use the tools of genetics, microscopy, and biochemistry to understand fundamental questions of cell biology: How are cells organized by the cytoskeleton? How does the cytoskeleton effect chromosome segretation with high fidelity? How is cell division coordinated with duplication of the centrosome, and what goes wrong in cancer cells defective in this coordination?

• 
  Steinman, Lawrence 
  Academic Appointments

  • Professor, Neurology & Neurological Sciences
  • Professor, Pediatrics
  • Professor (By courtesy), Genetics
  Clinical Focus

  • Neurology
  • Neurology, Pediatric
  • Multiple Sclerosis, Myasthenia Gravis, Immune Disorders
  Research Interest

  Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Sun, Zijie 
  Academic Appointments

  • Associate Professor, Urology
  • Associate Professor, Genetics
  • Member, Cancer Center
  Research Interest

  My laboratory focuses on understanding the transcriptional processes that govern the transformation of normal mammalian cells to neoplastic state.

T

• 
  Tan, Man-Wah 
  Academic Appointments

  • Assistant Professor, Genetics
  • Assistant Professor, Microbiology & Immunology
  • Member, Bio-X
  Research Interest

  Genome-wide analysis of host-pathogen interactions using a bacteria-C. elegans pathogenesis model; molecular mechanisms of virulence of bacterial pathogens; regulation of host-pathogen interactions by fatty acids and the nervous system; elucidate the distinctions in the regulation of immunity, stress and longevity.

• 
  Tang, Hua 
  Academic Appointments

  • Associate Professor, Genetics
  • Member, Bio-X
  Research Interest

  I am interested in various aspects of human genetics and genomics, including statistical and population genetics, mapping of disease susceptibility loci, and inference of the evolutionary histories of human populations. By integrating evolutionary theory into statistical modeling, my methodology research aims at developing analytic and computational approaches for identifying disease susceptibility loci in stratified or admixed populations. My applied research includes a large population-based ..

V

• 
  Villeneuve, Anne 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  Research Interest

  Mechanisms underlying homologous chromosome pairing, DNA recombination and chromosome remodeling during meiosis, using the nematode Caenorhabditis elegans as an experimental system. High-resolution 3-D imaging of dynamic reorganization of chromosome architecture. Role of protease inhibitors in regulating sperm activation.

• 
  Vollrath, Douglas 
  Academic Appointments

  • Associate Professor, Genetics
  • Associate Professor (By courtesy), Ophthalmology
  Research Interest

  We investigate molecular mechanisms underlying inherited forms of neurodegenerative blindness, specific cases of the more general problem of understanding how genotype manifests as phenotype. We study monogenic diseases, with the aim of gaining insight into biological pathways important in related but genetically complex forms of neurodegenerative blindness. A detailed understanding of pathogenic mechanisms leads us naturally to the development and preclinical testing of new therapies.