Solomon Owumi
Academic Appointments
- Postdoctoral Research fellow, Genetics
Key Documents
Contact Information
- Academic Offices
Personal Information Email
Professional Overview
Honors and Awards
- International Investigator Opportunity Grants, American Association for Cancer Research (2009)
- Undergraduate Scholar, Shell Petroleum Development Company (1996- 2000)
Professional Education
| Predoctoral Fellow: | Indiana University Purdue University, Indianapolis, Chemical carcinogenesis (2007) |
| Doctor of Philosophy: | University Of Ibadan (2009) |
Stanford Advisors
| Leonore Herzenberg: | Postdoctoral Faculty Sponsor |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
Acetaminophen N-acetyl-p-amino-phenol (APAP) , Tylenol - is an over the counter drug used for its analgesic, antipyretic and peripheral anti-inflammatory effects. APAP is the most widely studied of all drugs known to have hepatotoxic potentials. Its regioisomer N-acetyl-m-amino-phenol (AMAP) cause no injury to the liver and appears to be relatively safe. APAP overdose has been reported to cause liver injury, necrosis acute liver failure and over 450 deaths yearly in the United State. Implicated in these series of adverse effect is N-acetyl-p-benzoquinone imine (NAPQI) the reactive metabolite formed from a fraction of APAP metabolism by cytochrome p450 enzymes. Conjugation of NAPQI with glutathione (GSH) leads to its biliary excretion. Subsequent GSH depletion and accumulation of NAPQI, results in NAPQI preferential binding to cellular proteins and other macromolecules. NAPQI -protein binding is implicated in APAP toxicity. Consequently, activation of Kupffer cells (KC) and neutrophil recruitment exacerbate these situation. N-acetyl cysteine (NAC) from inception in the 1970s as a antidote of APAP toxicity, still finds relevance in the management of accidental or suicidal APAP overdose.
Publications
- Co-administration of sodium arsenite and ethanol: Protection by aqueous extract of Aframomum longiscapum seeds. Pharmacognosy Res. 2012; (3): 154-60
- Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice. Environ Toxicol. 2012
- Induction of micronuclei in bone marrow cells and hepatotoxicity of one of the most common over-the-counter pyrethriod insecticide products in Nigeria Toxicological and Environmental Chemistry. 2012; (9): 1822-1831
- Aflatoxin B₁ and ethanol co-exposure induces hepatic oxidative damage in mice. Toxicol Ind Health. 2010; (10): 717-24
- Petroleum Refining Chemicals Enhance Aflatoxin B1-induced Toxicities in Wistar Rats Journal of Medical Sciences. 2007; (4): 615 -619
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