David K. Stevenson, M.D.

Publication Details

• Effect of light exposure on metalloporphyrin-treated newborn mice.

  Schulz S, Wong RJ, Kalish FS, Zhao H, Jang KY, Vreman HJ, Stevenson DK. Pediatr Res. 2012; 72 (2): 161-8

  Neonatal hyperbilirubinemia arises from increased bilirubin production and decreased bilirubin elimination. Although phototherapy safely and effectively reduces bilirubin levels, recent evidence shows that it has adverse effects. Therefore, alternative treatments are warranted. Metalloporphyrins, competitive inhibitors of heme oxygenase (HO), the rate-limiting enzyme in bilirubin production, effectively reduce bilirubin formation; however, many are photoreactive. Here, we investigated possible photosensitizing effects of chromium mesoporphyrin (CrMP) and zinc deuteroporphyrin bis-glycol (ZnBG).

  PubMedID: 22580722