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David K. Stevenson, M.D.Academic Appointments
Appointment
Organization
Professor
Professor (By courtesy)
Member
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Honors & Awards
Title
Organization
Date(s)
Virginia Apgar Award in Perinatal Pediatrics
American Academy of Pediatrics
2006
MENTOR Award for Excellence in Research Training
The National Institute of Child Health and Human Development
2004
The Neonatal Education Award in Perinatal Pediatrics
American Academy of Pediatrics
2004
Advisor of Highest Distinction for Exemplary Contributions to Undergraduate Education
Stanford University
2004
The Duane Alexander Award for Academic Leadership in Perinatal Medicine
The National Institute of Child Health and Human Development
2003
8 honors and awards: view full list
Administrative Appointments
Title
Organization
Start Year
End Year
Vice Dean
Stanford University School of Medicine
2006
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Senior Associate Dean for Academic Affairs
Stanford University School of Medicine
2001
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Director, Charles B. and Ann L. Johnson Center for Pregnancy and Newborn Services
Lucile Packard Children's Hospital at Stanford
1997
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Harold K. Faber Professor of Pediatrics
Stanford University School of Medicine
1992
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Chief, Division of Neonatal and Developmental Medicine
Stanford University School of Medicine
1989
2007
7 appointments: view full list
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
B.A.
Stanford University
Philosophy
1971
M.D.
University of Washington School of Medicine
Medicine
1975
Web Site Links
Research/Lab website:
Division of Neonatal and Developmental Medicine
Research Interests
Our research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. To this end, we are actively investigating a more targeted, preventive approach to the diagnosis and treatment of newborns, who are high producers of the pigment and/or unable to efficiently eliminate bilirubin, thus leading to an accumulation of the pigment in circulation and tissues, which may lead to irreversible neurologic injury. Control of bilirubin production is a logical strategy, but has unexplored consequences for the immature mammal. Thus, we are studying the pivotal role of heme oxygenase (HO), the rate-limiting enzyme in the production of bilirubin, under a variety of commonly encountered pathological conditions, such as infection and hypoxia-ischemia, as well as in anti-oxidant defense, immune response and the regulation of hematopoiesis. In support of the above interests, studies are in progress, which are designed to screen a variety of metalloporphyrins and other compounds for maximum in vitro and in vivo efficacy with minimal side effects; to determine the ontogeny of the HO enzyme system in various murine tissues, focusing on perturbations resulting from treatment with HO inhibitors; and further to develop and test new technologies for noninvasive or minimally-invasive measurements of in vivo metabolism that could be used for diagnostic and monitoring purposes.
Publications
- Vreman HJ, Wong RJ, Murdock JR, Stevenson DK "Standardized bench method for evaluating the efficacy of phototherapy devices." Acta Paediatr 2008; More »
- Kaplan M, Renbaum P, Vreman HJ, Wong RJ, Levy-Lahad E, Hammerman C, Stevenson DK "(TA)n UGT 1A1 Promoter Polymorphism: A Crucial Factor in the Pathophysiology of Jaundice in G-6-PD Deficient Neonates." Pediatr Res 2007; More »
- Muchova L, Wong RJ, Hsu M, Morioka I, Vitek L, Zelenka J, Schröder H, Stevenson DK "Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection." Can J Physiol Pharmacol 2007; 85: 8: 800-10 More »
- Hsu M, Muchova L, Morioka I, Wong RJ, Schröder H, Stevenson DK "Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo." Biochem Biophys Res Commun 2006; More »
- Stevenson DK, "American Pediatric Society Presidential Address 2006: Science on the Edge With Life in the Balance." Pediatr Res 2006; More »
178 publications: view full list
