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Bryan MyersAcademic Appointments
Appointment
Organization
Emeritus (Active) Professor
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Research Interests
A differential solute clearance technique has been developed that characterizes the human glomerulus as an ultrafiltration membrane and macromolecular sieve. Filtration and plasma flow markers as well as probe macromolecules of varying size charge are used to determine glomerular ultrafiltration capacity and barrier selectivity in acute and chronic renal injuries. The physiologic characterization of glomerular capillary wall dysfunction is augmented by morphometric analysis of glomeruli from biopsy material. Serial physiologic and morphometric evaluation of several chronic glomerular diseases is being used to elucidate the pathogenesis of progression to renal failure in man. A similar approach that includes an analysis of pathobiology of postischemic injury to proximal tubules is being used to elucidate the mechanisms of filtration failure in acute renal failure.
Publications
- Lemley KV, Lafayette RA, Derby G, Blouch KL, Anderson L, Efron B, Myers BD "Prediction of early progression in recently diagnosed IgA nephropathy." Nephrol Dial Transplant 2007; More »
- Hladunewich MA, Derby GC, Lafayette RA, Blouch KL, Druzin ML, Myers BD "Effect of L-arginine therapy on the glomerular injury of preeclampsia: a randomized controlled trial." Obstet Gynecol 2006; 107: 4: 886-95 More »
- Saxena AB, Myers BD, Derby G, Blouch KL, Yan J, Ho B, Tan JC "Adaptive hyperfiltration in the aging kidney after contralateral nephrectomy." Am J Physiol Renal Physiol 2006; 291: 3: F629-34 More »
- Lemley KV, Boothroyd DB, Blouch KL, Nelson RG, Jones LI, Olshen RA, Myers BD "Modeling GFR trajectories in diabetic nephropathy." Am J Physiol Renal Physiol 2005; More »
- Hladunewich MA, Lafayette RA, Derby GC, Blouch KL, Bialek JW, Druzin ML, Deen WM, Myers BD "The dynamics of glomerular filtration in the puerperium." Am J Physiol Renal Physiol 2004; 286: 3: F496-503 More »
85 publications: view full list
