Mindie H. Nguyen, MD, MAS

Publication Details

• Precore and basal core promoter mutations in Asian American patients with hepatitis B e antigen-positive chronic hepatitis B.

  Vutien P, Trinh HN, Nguyen K, Garcia RT, Nguyen HA, Levitt BS, Nguyen L, Ha NB, Ahmed A, Daugherty T, Garcia G, Nguyen MH. Aliment Pharmacol Ther. 2013; 37 (4): 464-72

  Prior studies have shown that precore mutations abolish and basal core promoter (BCP) mutations down-regulate hepatitis B e antigen (HBeAg) production. Thus, the presence of precore and BCP mutations in HBeAg-positive patients indicates an infection with a mixed viral population of wild-type and precore and/or BCP mutant hepatitis B virus (HBV). To date, there has been limited study of the prevalence and clinical significance of precore and BCP mutations in patients with HBeAg-positive chronic hepatitis B.

  PubMedID: 23278246